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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 3 | Exploratory bioavailability and pharmacokinetic studies of sulphadime-thoxine and ormetoprim in the penaeid shrimp, Penaeus vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，： | 1 |
| 4 | Effect of changes in syringe driver height on flow~ a small quanti- tative study显示文摘 | Donald A I Chinthamuneedi M P Spearritt D | 2007 | Crit Care Resusc2007，9，2： | 1 |
| 5 | Mechanisms of adverse effects of anti-VEGF therapy for cancer 显示文摘 | Kamba T Mc Donald D M | 2007 | Br J Cancer2007，96，12： | 1 |
| 6 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | The Lancet2005，，9457： | 1 |
| 7 | Second-order nonlinearity in poled-polymer systems 显示文摘 | Donald M Burland Robert D Miller Ceeifia A Walsh | 1994 | Chem Rev1994，94，： | 1 |
| 8 | Second-order nonlinearity in poled-polymer systems显示文摘 | Donald M B Robert D M Cecilia A W | 1994 | Chem Rev1994，94，： | 1 |
| 9 | The effect of soil aggregate size on early shoot and root growth of maize 显示文摘 | Donald R G Kay B D Miller M H | 1987 | Plant Soil1987，103，： | 1 |
| 10 | Television and Attitudes Toward Mental Health Issues : Cultivation Analysis and the Third - person Effect 显示文摘 | Donald L Diefenbach M D W | 2007 | Joumal of Community Psychology2007，35，2： | 1 |
| 11 | Explora- tory SAXS and HPAEC-PAD studies of starches from diverse plant genotypes 显示文摘 | Sanderson J S Daniels R D Donald A M | 2006 | Carbohydrate Polymers2006，64，3： | 1 |
| 12 | Electrophilic C-H activation at fCp* Ix}: Ancillary- ligand control of the mechanism of CH activation显示文摘 | DAVIES D L DONALD S M AL- DUAIJ O | 2006 | Journal of the American Chemistry Society2006，128，13： | 1 |
| 13 | Transport and trafficking:Toxoplasma as a model for Plasmodium显示文摘 | ROOS D S CRAWFORD M J DONALD R G | 1999 | Novartis Found Syrup1999，226，： | 1 |
| 14 | What's new in orthopaedic trauma显示文摘 | Donald A Wiss M D | 2002 | J Bone Joint Surg Am2002，84，11： | 1 |
| 15 | Simultaneous multiresidue determination of tetracyclines and fluoroquinolones in catfish muscle us- ing high performance liquid chromatography with fluorescence detec- tion显示文摘 | Marilyn J S Ahmed M D Donald W F | 2007 | A nalytica Chimica A eta2007，586，： | 1 |
| 16 | Prevention and treatment of oral mucositis in children with cancer 显示文摘 | Miller M M Donald D V Hagemann T M | 2012 | J Pediatr Pharmacol Ther2012，17，4： | 1 |
| 17 | Resolution of High Molecular Weight Glutenin Subunits by a New SDSPAGE System in Corporatin Ganeutralp Hbuffer显示文摘 | DONALD D K KELLY M W ELVA A A | 1998 | Cereal Chem1998，75，1： | 1 |
| 18 | Synthesis procedures for p-tert-butylealixarene显示文摘 | Iqbal M Donald S | 1986 | Journal of Organic Chemistry1986，51，： | 1 |
| 19 | Distribution and regulation of urea in lakes of central North America 显示文摘 | Bogard M J Donald D B Finlay K | 2012 | Freshwater Biology2012，57，6： | 1 |
| 20 | Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study显示文摘 | Jadwiga A Wedzicha Marc Decramer Joachim H Ficker Dennis E Niewoehner Thomas Sandstr?m Angel Fowler Taylor Peter D’Andrea Christie Arrasate Hungta Chen Donald Banerji | 2013 | The Lancet Respiratory Medicine2013，，3： | 1 |
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