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| 1 | Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines显示文摘In the present study, total membrane proteins from tumor cell lines including HepG2, Hep3 B2,H226, Ovcar3 and N87 were extracted and digested with γLys C and trypsin. The resulting peptide lysate were pre-fractionated and subjected to untargeted quantitative proteomics analysis using a high resolution mass spectrometer. The mass spectra were processed by the Max Quant and the protein abundances were estimated using total peak area(TPA) method. A total of 6037 proteins were identified, and the analysis resulted in the identification of 2647 membrane proteins. Of those, tumor antigens and absorption,metabolism, disposition and elimination(ADME) proteins including UDP-glucuronosyltransferase,cytochrome P450, solute carriers and ATP-binding cassette transporters were detected and disclosed significant variations among the cell lines. The principal component analysis was performed for the cluster of cell lines. The results demonstrated that H226 is closely related with N87, while Hep3 B2 aligned with HepG2. The protein cluster of Ovcar3 was apart from that of other cell lines investigated. By providing for the first time quantitative untargeted proteomics analysis, the results delineated the expression profiles of membrane proteins. These findings provided a useful resource for selecting targets of choice for anticancer therapy through advancing data obtained from preclinical tumor cell line models to clinical outcomes. | Xiaomei Gu Qing Xiao Qian Ruan Yuezhong Shu Ashok Dongre Ramaswamy Iyer W.Griffith Humphreys Yurong Lai | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 2 | Petrology,genesis and geodynamic implication of the Mesoproterozoic-Late Cretaceous Timmasamudram kimberlite cluster,Wajrakarur field,Eastern Dharwar Craton,southern India显示文摘New mineralogical and bulk-rock geochemical data for the recently recognised Mesoproterozoic(ca.1100 Ma) and late Cretaceous(ca.90 Ma) kimberlites in the Timmasamudram cluster(TKC) of the Wajrakarur kimberlite field(WKF),Eastern Dharwar Craton,southern India,are presented.On the basis of groundmass mineral chemistry(phlogopite,spinel,perovskite and clinopyroxene),bulk-rock chemistry(SiO_2.K_2O,low TiO_2.Ba/Nb and La/Sm),and perovskite Nd isotopic compositions,the TK-1(macrocrystic variety) and TK-4(Macrocrystic variety) kimberlites in this cluster are here classified as orangeites(i.e.Group Ⅱ kimberlites),with geochemical characteristics that are very similar to orangeites previously described from the Bastar Craton in central India,as well as the Kaapvaal Craton in South Africa.The remaining kimberlites(e.g.,TK-2,TK-3 and the TK-1 microcrystic variant),are more similar to other 1100 Ma,Group Ⅰ-type kimberlites of the Eastern Dharwar Craton,as well as the typical Group Ⅰkimberlites of the Kaapvaal Craton.Through the application of geochemical modelling,based on published carbonated peridotite/melt trace element partition coefficients,we show that the generation of the TKC kimberlites and the orangeites results from low degrees of partial melting of a metasomatised,carbonated peridotite.Depleted mantle(T_(DM)) Nd perovskite model ages of the 1100 Ma Timmasamudram kimberlites show that the metasornatic enrichment of their source regions are broadly similar to that of the Mesoproterozoic kimberlites of the EDC.The younger,late Cretaceous(ca.90 Ma) TK-1(macrocrystic variant)and TK-4 kimberlites,as well as the orangeites from the Bastar Craton,share similar Nd model ages of1100 Ma,consistent with a similarity in the timing of source enrichment during the amalgamation of Rodinia supercontinent.The presence of late Cretaceous diamoncliferous orangeite activity,presumably related to the location of the Marion hotspot in southern India at the time,suggests that thick Iithosphere was preserved,at least locally,up to the late Cretaceous,and was not entirely destroyed during the breakup of Gondwana,as inferred by some recent geophysical models. | Ashish Dongre N.V.Chalapathi Rao K.S.Viljoen B.Lehmann | 2017 | Geoscience Frontiers2017，8，3： | 2 |
| 3 | Cytological study of palpable breast lumps presenting in an Indian rural setup显示文摘 | Sankaye SB Dongre SD | 2014 | Indian J Med Paediatr Oncol2014，35，2： | 1 |
| 4 | Proposed refinement to the superpave high temperature specification parameter for performance graded binder 显示文摘 | Bouldin M G Dongre R D'Angelo J | 2001 | Transportation Research Record2001，，1766： | 1 |
| 5 | Role of parecoxib in pre-emptive analgesia:comparison of the efficacy and safety of pre-and postoperative parecoxib in patientsundergoing general surgery 显示文摘 | BAJAJ P BALLARY C C DONGRE N A | 2004 | J Indian Med Assoc2004，102，5： | 1 |
| 6 | Creep and recovery显示文摘 | D Angelo J A R Dongre G Reinke | 2007 | Public roads2007，，70： | 1 |
| 7 | Predicting thermal cracking of pavements fi'om binder properties: Theoretical basis and field validation 显示文摘 | Bouldin M G Dongre R Rowe G M M | 2000 | Proceedings of the Association of Asphalt Paving Technologists2000，69，： | 1 |
| 8 | Efficacy, safety, and tolerability of valsartan/hydrochlorothiazide in Asian patients with essential hyper- tension显示文摘 | Lai WT Park JE Dongre N | 2011 | Adv Ther2011，28，5： | 1 |
| 9 | Imatinib mesylate induced erythroderma显示文摘 | Sanghavi SA Dongre AM Khopkar US | 2012 | Indian J Dermatol Venereol Leprol2012，78，： | 1 |
| 10 | Acquired smooth muscle hamartoma显示文摘 | Adulkar SA Dongre AM Thatte SS | 2014 | Indian J Dermatol Venereol Leprol2014，80，5： | 1 |
| 11 | A new classifier for handling concept drifting data stream 显示文摘 | Rangari S R Dongre S S Malik L G | 2013 | International Jour- nal of Science and Research2013，2，5： | 1 |
| 12 | Role of parecoxib in pre-emptive analgesia:comparison of the efficacy and safety of pre-and postoperative parecoxib in patients undergoing general surgery显示文摘 | BajajP Ballary CC Dongre NA | | 0，，05： | 1 |
| 13 | Long and short-term floding effects on survival and sink-source relationships of swamp-adapted tree species显示文摘 | Angelov M N Sung S J S DongR L etal | 1996 | Tree Physiology1996，16，5： | 1 |
| 14 | The benefits to medical un- dergraduates of exposure to community-based survey research 显示文摘 | Dongre AR Kalaiselvan G Mahalakshmy T | 2011 | Educ Health ( Abingdon )2011，24，3： | 1 |
| 15 | Influence of Peptide Composition, Gas-Phase Basicity and Chemical Modification on Fragmentation Efficiency: Evidence for the Mobile Proton Model显示文摘 | DONGRE A R JONES J L SOMOGYI A | 1996 | J Am Chem Soc1996，118，： | 1 |
| 16 | Increased level of superoxide dismutase (SOD) activity in larvae of Chironomus ramosus (Diptera: Chironomidae) subjected to ionizing radiation显示文摘 | K.D. Datkhile R. Mukhopadhyaya T.K. Dongre B.B. Nath | 2008 | Comparative Biochemistry and Physiology Part C2008，，4： | 1 |
| 17 | Radio-sensitivity of different developmental stages of pulse beetle(Callosobruchus maculatus)显示文摘 | DONGRE T K HARWALKAR K NENE S P | 1997 | Journal of Food Science and Technology(Mysore)1997，34，5： | 1 |
| 18 | Physical and dosimetric characteristic of high-definition multileaf collimator (HDMLC) for SRS and IMRT显示文摘 | Sharma DS Dongre PM Mhatre V | 2011 | J Appl Clin Med Phys2011，12，3： | 1 |
| 19 | Evaluation of automated image registration algorithm for image-guided radiotherapy (IGRT)显示文摘 | Sharma SD Dongre P Mhatre V | 2012 | Austral Phys Eng Sci Med2012，35，： | 1 |
| 20 | Efficacy,salety,and tolerability of valsartan/hydrochlorothiazide in Asian sential hypertension显示文摘 | Lai WT Park JE Dongre N | | 0，，05： | 1 |
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