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| 1 | 卫生经济学评价报告标准共识2022(CHEERS 2022):卫生经济学评价报告指导意见更新版显示文摘卫生经济学评价是对备选行动方案的成本和结果的比较分析。2013年发表的《卫生经济学评价报告标准共识》(CHEERS)提出了卫生经济学评价的特点,确保结果正确阐释,以支持决策制订。2013版CHEERS旨在指导研究报告撰写者准确报告卫生干预和对照措施、背景、过程、结果等评价细节,使审稿人理解文章内容,帮助读者使用研究结果。本版共识将取代2013版共识,其更加适用于各类卫生经济学评价,结合学科发展和方法更新的需要,更注重患者、公众等相关利益方的参与。本共识适用多种个体或人群健康干预措施(简单或复杂)在不同政策场景的应用分析,包括医疗服务、公共卫生、教育、社会服务等。本文概要介绍了CHEERS 2022共识中包含的28个检查项及每一个检查项的相关建议。CHEERS 2022共识主要用于指导研究人员撰写拟投递同行评议学术期刊的卫生经济学评价文章,亦可用于期刊编辑和审稿专家对待发表文章的评价。熟悉了解本共识要求,还有助于研究人员规划评价研究。随着决策透明度要求提高,本共识可支持卫生技术评估机构建立评价报告标准。 | Don Husereau Michael Drummond Federico Augustovski Esther de Bekker-Grob Andrew H Briggs Chris Carswell Lisa Caulley Nathorn Chaiyakunapruk Dan Greenberg Elizabeth Loder Josephine Mauskopf C Daniel Mullins Stavros Petrou Raoh-Fang Pwu Sophie Staniszewska on behalf of CHEERSISPOR Good Research Practices Task Force 肖月(译) 邱英鹏(译) 史黎炜(译) 张治国(译) 张歆(译) 王海银(译) 翟铁民(译) | 2022 | 英国医学杂志中文版2022，25，8： | 31 |
| 2 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 3 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 4 | 色氨酸耗竭对偏头痛患者运动病症状的影响 | Drummond P.D. 王孝文 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，12： | 11 |
| 5 | Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo显示文摘Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully understood.Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner.The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen deficiency.Estrogen replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four weeks.Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo.Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling. | Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu | 2011 | Protein & Cell2011，2，4： | 8 |
| 6 | 迈向完整、准确的诊断准确性研究报告:STARD计划显示文摘背景要理解诊断准确性研究的结果,读者必须了解其设计、实施、分析及结果。这只能通过作者完全公开研究资料才能实现。目的提高诊断准确性研究报告的准确性和完整性,以便读者评估研究的偏倚可能性及推广性。方法诊断准确性研究报告标准(STARD)指导委员会通过文献检索,找出正确实施和报告的诊断性试验,并提取可能有用的条目形成一份泛表。再由研究人员、编辑及相关专业组织成员在为期两天的共识会议中对这份泛表进行缩减,以制定出一份诊断准确性研究的清单和通用流程图。结果检索已发表的诊断性研究指南,共找到33份清单,从中提取出75项可能有用的条目。根据当前可得的所有提示偏倚的证据,将之缩减至25项条目。制定出的典型流程图提供了招募患者的方法、执行“诊断措施”的顺序及接受试验诊断措施或/和金标准诊断措施的患者人数等信息。结论判断研究的价值有赖于完整、准确的报告。若医学期刊采用此清单和流程图,诊断准确性研究报告的质量将会有所提高,更好地服务于临床医生、研究人员、评价者、期刊及公众。 | Patrick M.Bossuyt Johannes B.Reitsma David E.Bruns Constantine A.Gatsonis Paul P.Glasziou Les M.Irwig Jeroen G.Lijmer David Moher Drummond Rennie Henrica C.W.de Vet the STARD Group 刁骧 秦莉 姚巡 | 2006 | 中国循证医学杂志2006，6，7： | 5 |
| 7 | ^(18)F-FDG PET/CT发现肿瘤患者意外病灶的临床价值显示文摘目的评价^(18)F-脱氧葡萄糖(FDG)PET/CT 全身显像探测肿瘤患者意外病灶的临床价值。方法回顾性分析澳大利亚 Peter MacCallum 肿瘤医院 PET/CT 中心2002年8月~2003年7月1727例肿瘤患者^(18)F-FDG PET/CT 全身显像报告,男980例,女747例,中位年龄63岁,随访37个月(中位时间为27.5个月)。意外病灶指新发现的与原发肿瘤无关的良性病灶或第2原发肿瘤。通过分析病历记录、病理结果、其他影像学检查结果及临床随访,确定病灶最终结果。结果 1727例患者共发现238例(13.8%)有意外病灶,其中213例220个意外病灶具有完整的随访资料。60个病灶怀疑为意外第2原发肿瘤,其中21.7%(13/60)证实为真阳性,70.0%(42/60)为假阳性,8.3%(5/60)至研究结束时未得到证实。38个甲状腺意外良性病灶,其中9个被证实为临床前恶性或恶性病灶,26个良性,3个未能证实。38个纵隔意外良性病灶,其中86.8%(33/38)证实为良性,7.9%(3/38)为原发肿瘤淋巴结侵犯,5.3%(2/38)未能证实其性质。其他部位84个意外良性病灶,94.0%(79/84)证实为真阴性,6.0%(5/84)未能证实。共22例患者被证实存在第2原发肿瘤病灶,占本研究总人群的1.3%。结论 ^(18)F-FDG PET/CT 全身显像是目前探测肿瘤患者意外病灶较好的无创方法,为制定临床治疗方案提供及时准确的依据。 | 王国慧 Eddie W.F. Lau Ramdave Shakher Robert E.Ware David S.Binns Annette Hogg Elizabeth Drummond Rodney J.Hicks | 2007 | 中华核医学杂志2007，27，1： | 3 |
| 8 | Carbon dioxide insufflation during colonoscopy in deeply sedated patients显示文摘AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation. | Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon Drummond Garry Nind Elizabeth Murphy Andrew Luck Graeme Tucker William Tam | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 9 | The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis显示文摘Alzheimer’s disease(AD)is broadly defined by dementia and the presence of specific neuropathological features in the brain(amyloid plaques,neurofibrillary tangles(NFTs)and congophilic amyloid angiopathy).However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD(Murray et al.,2011).Why this occurs is still unknown。 | Eleanor Drummond Thomas Wisniewski | 2017 | Neural Regeneration Research2017，12，6： | 2 |
| 10 | It takes more than tau to tangle:using proteomics to determine how phosphorylated tau mediates toxicity in neurodegenerative diseases显示文摘Two of the most common causes of dementia are Alzheimer’s disease(AD)and frontotemporal dementia(FTD).AD is an irreversible,progressive neurodegenerative disorder that is clinically characterized by severe memory loss and behavioral impairment that eventually interferes with everyday function.AD is neuropathologically defined by the presence of extracellularβ-amyloid plaques and intracellular accumulation of neurofibrillary tangles(NFTs)that primarily contain aggregated,hyperphosphorylated tau(pTau).Intriguingly,pTau is also the central protein in multiple subtypes of FTD(e.g.corticobasal degeneration,progressive supranuclear palsy,Pick’s disease).FTD is an umbrella term for a group of neurological conditions that primarily affect the temporal and frontal regions of the brain.Mutations in the tau gene(MAPT)can cause familial FTD,providing further evidence of the integral role of tau in FTD.Physiologically,tau regulates microtubule structure and dynamics,as well as axonal transport through interaction with tubulin.Tau is also involved in neuronal development and synaptogenesis.In AD and FTD,tau becomes hyperphosphorylated and undergoes major conformational changes,causing it to aggregate into the characteristic neuropathological lesions that define AD and FTD.Despite the known involvement of tau in these diseases,exactly how tau mediates toxicity is still unclear. | Geoffrey Pires Eleanor Drummond | 2021 | Neural Regeneration Research2021，16，11： | 2 |
| 11 | The impact of PET/CT in the management of recurrent ovarian cancer显示文摘 | Bryony Simcock Deborah Neesham Michael Quinn Elisabeth Drummond Alvin Milner Rodney J. Hicks | 2006 | Gynecologic Oncology2006，，： | 2 |
| 12 | Design Optimization and Weight Reduction of 500 mL CSD PET Bottle through FEM Simulations显示文摘 | Carlos Alberto Silva De Miranda Jairo Jose Drummond Camara Olavo Pena Monken Claudio Gouvea Dos Santos | 2011 | 材料科学与工程(中英文B版)2011，1，7： | 2 |
| 13 | Real-time visual tracking of complex structures 显示文摘 | DRUMMOND T CIPOLLA R | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，7： | 1 |
| 14 | Colorado potato beetle response to soil amendments:A case in support of the mineral balance hypothesis?显示文摘 | Alyokhin A Porter G Groden E Drummond F | 2005 | Agriculture Ecosystems and Environment2005，109，： | 1 |
| 15 | Regulation of the FSH Receptor in the Ovary显示文摘 | Findlay JK Drummond AE | 1999 | Trends Endocrinol Metab1999，10，5： | 1 |
| 16 | Blood flow restriction during low-intensity resistance exercise increase S6K1 phos- phorylation and muscle protein synthesis 显示文摘 | Fnjita S Abe T Drummond MJ | 2007 | J Appl Physiol2007，103，3： | 1 |
| 17 | Meningiomas:updating basic science,management,and outcome显示文摘 | Drummond KJ Zhu JJ Black PM | 2004 | Neurologist2004，10，： | 1 |
| 18 | Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration 显示文摘 | Grifoni S C McKey S E Drummond H A | 2008 | Am J Physiol Heart Circ Physiol2008，294，5： | 1 |
| 19 | Derivation of some modem arc mag- mas by melting of young subduction lithosphere显示文摘 | Defant M J Drummond M S | 1990 | Nature1990，347，： | 1 |
| 20 | 查看详情显示文摘 | X J Liu H Hu P D Drummond | | 0，，16： | 1 |
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