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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Stress, depression, and neuroplasticity: a convergence of mechanisms 显示文摘 | Pittenger C Duman R S | 2008 | Neuropsychopharmacology2008，33，1： | 1 |
| 3 | Plant thermal hysteresis proteins显示文摘 | URRUTIA M E DUMAN J G KNIGHT C A | 1992 | Biochim Biophys Acta1992，1121，1： | 1 |
| 4 | Inhibition of recrystallization of ice by inset thermal hysteresis proteins: a possible cryopro- tective role显示文摘 | Knight C A Duman J G | 1986 | Cryobiology1986，23，： | 1 |
| 5 | French pe- ritoneal dialysis registry (RDPLF) : outline and main re- suits显示文摘 | Verger C Ryckelynck J P Duman M | 2006 | Kidney Int Suppl2006，，103： | 1 |
| 6 | Isolation and characterization of cDNA clones encoding antifreeze proteins of the pyrochroid beetle Dendroides canadensis显示文摘 | Andorfer C A Duman J G | 2000 | J Insect Physiol2000，46，： | 1 |
| 7 | Antidepressants and neuroplasticity 显示文摘 | D'Sa C Duman RS | 2002 | Bipolar Disord2002，4，3： | 1 |
| 8 | Allee effect in a discrete-time predator-prey system显示文摘 | elik C Duman O | 2009 | Chaos Solitons and Fractals2009，40，： | 1 |
| 9 | Stress, depression, and neuroplasticity , a convergence of mechanisms显示文摘 | Pittenger C Duman RS | 2008 | Neuropsychopharmacology2008，33，1： | 1 |
| 10 | TNF alpha signaling in depression and anxiety:Behavioral consequences of individual recep- tor targeting显示文摘 | Simen B B Duman C H Simen A A | 2006 | Biol Psychiatry2006，59，9： | 1 |
| 11 | Elevated serum CA12 levels in mitral stenotic patientswith heart failure 显示文摘 | Duman C Ercan E Tengiz I | 2003 | Cardiology2003，100，： | 1 |
| 12 | Elevated serum CA125 levels in mitral stenotic patients with heart failure 显示文摘 | Duman C Ercan E Tengiz I | 2003 | Cardiology2003，100，1： | 1 |
| 13 | Elevated serum CA 125 levels in mitraI stenotic patients with heart failure显示文摘 | Duman C Ercan E Tengiz I | | 0，，09： | 1 |
| 14 | Antidepressants and neuroplasticity显示文摘 | D’Sa C Duman R S | 2002 | Bipolar Disord2002，4，3： | 1 |
| 15 | Stoichiometric Desmonocristaux de Metaniobate Delithium显示文摘 | Lerner P Legras C Duman J P | 1968 | Journal of Crystal Growth1968，314，： | 1 |
| 16 | Inhibition of recrystallization of ice by inset thermal hysteresis proteins: a possible cryopro- tective role显示文摘 | Knight C A Duman J G | 1986 | Cryobiology1986，23，3： | 1 |
| 17 | Stress, depression, and neuroplasticity: A convergence of mechanisms 显示文摘 | Pittenger C Duman RS | 2007 | Neuropsychopharmacology2007，33，1： | 1 |
| 18 | Facility Layout Design with Genetic Algorithms and an Application 显示文摘 | Gtilstln B Tuzkaya G Duman C | 2009 | DUMAN Dogns University Journal2009，20，10： | 1 |
| 19 | Plant thermal hysteresis proteins显示文摘 | Urrutia M E Duman J G Knight C A | 1992 | Biochim Biophy Acta1992，1121，1： | 1 |
| 20 | Correlation between c - erbB2 expression, lymphovascular invasion and other biological and clini- cal prognostic factors and preoperative tumor markers in patientswith early - stage and locally advanced breast cancer 显示文摘 | Aksu G Duman C Gurbuz Y | 2011 | J BUON2011，16，1： | 1 |
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