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| 1 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 2 | Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins显示文摘The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been described.The traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 m.The stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional technique.These results show that the selective technique is also more convenient.This proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,etc.such as the famous La Rinconada gold mine in the Peruvian Andes. | Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde Costa e Silva Paula Falcao Neves Qiang Xie | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，1： | 7 |
| 3 | Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles显示文摘Studies in recent years have shown that aquatic pollution by microplastics(MPs)can be considered to pose additional stress to amphibian populations.However,our knowledge of how MPs affect amphibians is very rudimentary,and even more limited is our understanding of their effects in combination with other emerging pollutants.Thus,we aimed to evaluate the possible toxicity of polyethylene MPs(PE-MPs)(alone or in combination with a mix of pollutants)on the health of Physalaemus cuvieri tadpoles.After 30 days of exposure,multiple biomarkers were measured,including morphological,biometric,and developmental indices,behavioral parameters,mutagenicity,cytotoxicity,antioxidant and cholinesterase responses,as well as the uptake and accumulation of PE-MPs in animals.Based on the results,there was no significant change in any of the parameters measured in tadpoles exposed to treatments,but induced stress was observed in tadpoles exposed to PE-MPs combined with themixture of pollutants,reflecting significant changes in physiological and biochemical responses.Through principal component analysis(PCA)and integrated biomarker response(IBR)assessment,effects induced by pollutants in each test group were distinguished,confirming that the exposure of P.cuvieri tadpoles to the PE-MPs in combination with a mix of emerging pollutants induces an enhanced stress response,although the uptake and accumulation of PE-MPs in these animalswas reduced.Thus,our study provides newinsight into the danger to amphibians of MPs coexisting with other pollutants in aquatic environments. | Amanda Pereira da Costa Araújo Thiarlen Marinho da Luz Mohamed Ahmed Ibrahim Ahmed Mir Mohammad Ali Md.Mostafizur Rahman Bojan Nataraj Daniela de Melo e Silva DamiàBarceló Guilherme Malafaia | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 4 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 5 | α-synucleinLowersp 53-dependent apoptotic response of neuronal cells显示文摘 | Aires da Costa C Paitel E Vincent B | 2002 | J Biological Chemistry2002，277，50： | 1 |
| 6 | Tobacco use and control:determi-nants of consumption, intervention strategies, and the role of the to- bacco industry显示文摘 | da Costa e Silva VL Fishburn B | 2004 | Toxicology2004，198，13： | 1 |
| 7 | Scientific Collaboration in Biotechnology : the Case of the Northeast Region in Brazil 显示文摘 | Costa B M G da Silva Pedro E de Macedo G R | 2013 | Scientometrics2013，，： | 1 |
| 8 | Nephrotie syndrome in brochogenic carcinoma:report of two cases with immunochemical studies显示文摘 | da Costa CR Dupont E Hamers R | 1974 | Clin Nephrol1974，2，6： | 1 |
| 9 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 10 | Clinical characteristics,aetiological factors and long-term prognosis of myocardial infarction with an absolutely normal coronary angiogram显示文摘 | Da Costa A Isaaz K Faure E | 2001 | Eur Heart J2001，22，16： | 1 |
| 11 | Clinical characteristics, aetiological factors and long-term prognosis of myocardial in- farction with an absolutely normal coronary angiogram ; a 3-year follow-up study of 91 patients 显示文摘 | Da Costa A Isaaz K Faure E | 2001 | Eur Heart J2001，22，16： | 1 |
| 12 | Characterization of polymeric insulators using thermal and UV imaging under laboratory conditions显示文摘 | Da Costa E G Ferreira T V Neri M G G | 2009 | IEEE Transactions on Dielectrics and Electrical Insulation2009，16，4： | 1 |
| 13 | Kinetic modelling of steam gasification of various woody biomass chars:Influence of inorganic elements显示文摘 | Dupont Capucine Nocquet Timothée José Augusto Da Costa Jr | 2011 | Bioresource Technology2011，102，20： | 1 |
| 14 | Voltage sag per- formance of a distribution system and its improvement 显示文摘 | Naidu S R de Andrade G V da Costa E G | 2012 | IEEE Transactions on Industry Application2012，48，1： | 1 |
| 15 | The diffusion of technological knowledge through interlaced networks显示文摘 | Leonardo Costa Ribeiro Ricardo Machado Ruiz Eduardo da Motta e Albuquerque Américo T. Bernardes | 2010 | Computer Physics Communications2010，，9： | 1 |
| 16 | Film growth and relationship between microstructure and mechanical properties of a-C: H: F films deposited by PECVD显示文摘 | Maia da Costa M E H Jacobsohn L G | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 17 | Artificial neural networks used for ZnO arresters diagnosis显示文摘 | Wanderley Neto E T da Costa E G Mala M J A | 2009 | IEEE Transactions on Power Delivery2009，24，3： | 1 |
| 18 | Evaluation of red cell and reticulocyte parameters as indicative of iron deficiency in patients with anemia of chronic disease 显示文摘 | Torino A B B Gilberti M F P da Costa E | 2014 | Revista Brasileira de Hematologia e Hemoterapia2014，36，6： | 1 |
| 19 | Acrylamide formed at physiological temperature as a result of asparagine oxidation显示文摘 | TAREKE E HEINZET T M da COSTA G G | 2009 | Jour- nal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 20 | Optimisation of wave energy extraction with the Archimedes wave swing显示文摘 | VAL(E)RIO D BEIR(A)O P S(A)DA COSTA J | | 0，，17： | 1 |
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