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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Biliary complications after pediatric liver transplantation: Risk factors, diagnosis and management显示文摘The expanded indications of partial grafts in pediatric liver transplantation have reduced waiting list mortality. However, a higher morbidity is observed, including an increased rate of biliary complications(BCs). Factors such as the type of graft, the preservation methods applied, the donor characteristics, the type of biliary reconstruction, and the number of bile ducts in the liver graft influences the occurrence of these complications. Bile leaks and strictures comprise the majority of posttransplant BCs. Biliary strictures require a high grade of suspicion, and because most children have a bileoenteric anastomosis, its diagnosis and management rely on percutaneous hepatic cholangiography and percutaneous biliary interventions(PBI). The success rates with PBI range from 70% to 90%. Surgery is reserved for patients who have failed PBI. BCs in children after liver transplantation have a prolonged treatment and are associated with a longer length of stay and higher hospital costs. However, with early diagnosis and aggressive treatment, patient and graft survival are not significantly compromised. | Flavia H Feier Eduardo A da Fonseca Joao Seda-Neto Paulo Chapchap | 2015 | World Journal of Hepatology2015，7，18： | 4 |
| 3 | Idiopathic sudden sensorineural hearing loss:Effectiveness of salvage treatment with low-dose intratympanic dexamethasone显示文摘Objectives:To evaluate hearing outcome of salvage treatment with intratympanic steroids(ITS)in idiopathic sudden sensorineural hearing loss(ISSNHL)refractory to initial systemic steroid(SS)therapy.Material and methods:A retrospective medical chart review was conducted on 54 consecutive patients with ISSNHL refractory to SS.Salvage treatment with a low dose intratympanic dexamethasone(4 mg/ml)was offered after one week of primary treatment.Patients were divided into two groups:25 patients accepted ITS(treatment group)and 29 patients did not undergo additional treatment(control group).A pure tone average(PTA)gain of at least 10 dB was considered hearing improvement.Results:Hearing improvement rate was higher in ITS group compared to control group(40%vs.13.8%,p=0.035).A mean PTA improvement of 8.6±9.8 dB was observed in the ITS group and,whereas the control group had an average hearing gain of 0.7±2 dB(p<0.001).Audiometric analysis revealed a significant hearing gain in ITS group at all tested frequencies compared to control group(p<0.05).Analysis of the selected variables,identified intratympanic steroid treatment as the only independent prognostic factor for hearing improvement(OR=4.2,95%CI:1.1e15.7;p=0.04).Conclusion:Intratympanic low dose dexamethasone is effective in patients with incomplete hearing recovery after primary systemic steroid treatment. | Pedro Salvador Francisco Moreira da Silva Rui Fonseca | 2021 | Journal of Otology2021，16，1： | 3 |
| 4 | Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging显示文摘Rheumatoid arthritis(RA)is an autoimmune disease,which is associated with systemic and chronic inflammation of the joints,resulting in synovitis and pannus formation.For several decades,the assessment of RA has been limited to conventional radiography,assisting in the diagnosis and monitoring of disease.Nevertheless,conventional radiography has poor sensitivity in the detection of the inflammatory process that happens in the initial stages of RA.In the past years,new drugs that significantly decrease the progression of RA have allowed a more efficient treatment.Nuclear Medicine provides functional assessment of physiological processes and therefore has significant potential for timely diagnosis and adequate follow-up of RA.Several single photon emission computed tomography(SPECT)and positron emission tomography(PET)radiopharmaceuti-cals have been developed and applied in this field.The use of hybrid imaging,which permits computed tomography(CT)and nuclear medicine data to be acquired and fused,has increased even more the diagnostic accuracy of Nuclear Medicine by providing anatomical localization in SPECT/CT and PET/CT studies.More recently,fusion of PET with magnetic resonance imaging(PET/MRI)was introduced in some centers and demonstrated great potential.In this article,we will review studies that have been published using Nuclear Medicine for RA and examine key topics in the area. | Paulo Henrique Rosado-de-Castro Sergio Augusto Lopes de Souza Dangelo Alexandre Lea Mirian Barbosa da Fonseca Bianca Gutfilen | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 5 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 6 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 7 | Long-term probabilistic evaluation of operating reserve requirements with renewable sources显示文摘 | da SILVA A M L SALES W S da FONSECA MANSO L A | 2010 | IEEE Trans on Power Systems2010，25，1： | 1 |
| 8 | Safty of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke显示文摘 | Battistella V de Freitas GR da Fonseca LM | 2011 | Regen Med2011，6，1： | 1 |
| 9 | Unplanned endotracheal extubatlons m the intensive care unit:systematic review,critical appraisal,and evidence-based recommendations显示文摘 | da Silva PS Fonseca MC | 2012 | Anesth Analg2012，114，5： | 1 |
| 10 | Ecological quality assessment of small estuaries from the Portuguese coast based on fish assemblages indices显示文摘 | Inês Cardoso Miguel Pessanha Pais Sofia Henriques Luís Cancela da Fonseca Henrique N. Cabral | 2011 | Marine Pollution Bulletin2011，，5： | 1 |
| 11 | Receding forest edges and vanishing reserves显示文摘 | Gascon C Williamson G B da Fonseca G A B | 2000 | Science2000，288，： | 1 |
| 12 | Detection of parvovirus B19 infection in formalin-fixed and paraffinembedded placenta and fetal tissues显示文摘 | Quemelo PR Lima DM da Fonseca BA | | Revista Do Instituto De Medicina Tropical De Sao Paulo0，，： | 1 |
| 13 | Detection of new art-4 and arr-5 gene cassettes in clinical Pseudomonas aerugi-nosa and Klebsiella pneumoniae strains from Brazil显示文摘 | da Fonseca EL Freitas Fdos S de Amorim JC | | 0，，05： | 1 |
| 14 | Ras pathway activation in gliomas:a strategic target for intranasal administration of perillyl alcohol显示文摘 | Da Fonseca CO Linden R Futuro D | | 0，，04： | 1 |
| 15 | Chemical effects on the soil-plant system in a secondary treated wastewater irrigated coffee plantation-A pilot field study in Brazil显示文摘 | Uwe Herpin Thomas Vincent Gloaguen Adriel Ferreira da Fonseca | 2007 | Agricultural Water Management2007，89，： | 1 |
| 16 | predictive factors for response to Lamivudine in chronic hepatitis B显示文摘 | Da Silva LC da Fonseca LE carrilho FJ | 2000 | Rev Inst Med Trop Sao Paulo2000，42，： | 1 |
| 17 | The remarkable Rhodococcus erythropolis显示文摘 | de Carvalho C C da Fonseca M M 2005 | 2005 | Appl Microbiol Biotechnol2005，67，： | 1 |
| 18 | Bioaugmentationand biostimulation strategies to improve the effectiveness of bioremediation processes显示文摘 | Tyagi M da Fonseca MMR de Carvalho CCCR | 2011 | Biodegradation2011，22，23： | 1 |
| 19 | Survey of infectious and parasitic diseases in stray cats at the Lisbon Metropolitan Area, Portugal显示文摘 | Ana Duarte Isabel Castro Isabel M. Pereira da Fonseca Virgilio Almeida Luis M. Madeira de Carvalho José Meireles Maria I. Fazendeiro Luis Tavares Yolanda Vaz | 2009 | Journal of Feline Medicine and Surgery2009，，6： | 1 |
| 20 | Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy显示文摘 | Pimentel-Coelho PM Rosado-de-Castro PH da Fonseca LM | 2012 | Pediatr Res2012，71，42： | 1 |
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