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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | Ca^(2+) involvement in activation of extracellular-signal- regulated-kinase 1/2 and m-calpain after axotomy of the sciatic nerve显示文摘Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells(SCs), are poorly understood. Here, we investigated axotomy-induced activation of extracellular-signal-regulated kinase-1/2(ERK1/2; important for proliferation) and m-calpain in vitro, and the relation to Ca2+ deletion and Schwann cell proliferation and death after rat sciatic nerve axotomy. Nerve segments were cultured for up to 72 hours with and without ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid(EGTA). In some experiments, 5-bromo-2′-deoxyuridine(Brd U) was added during the last 24 hours to detect proliferating cells and propidium iodide(PI) was added at the last hour to detect dead and/or dying cells. Immunohistochemistry of sections of the cultured nerve segments was performed to label m-calpain and the phosphorylated and activated form of ERK1/2. The experiments revealed that immunoreactivity for p-ERK1/2 increased with time in organotypically cultured SCs. p-ERK1/2 and m-calpain were also observed in axons. A significant increase in the number of dead or dying SCs was observed in nerve segments cultured for 24 hours. When deprived of Ca2+, activation of axonal m-calpain was reduced, whereas p-ERK1/2 was increased in SCs. Ca2+ deprivation also significantly reduced the number of proliferating SCs, and instead increased the number of dead or dying SCs. Ca2+ seems to play an important role in activation of ERK1/2 in SCs and in SC survival and proliferation. In addition, extracellular Ca2+ levels are also required for m-calpain activation and up-regulation in axons. Thus, regulation of Ca2+ levels is likely to be a useful method to promote SC proliferation. | Lisa B. Martensson Charlotta Lindwall Blom Lars B. Dahlin | 2017 | Neural Regeneration Research2017，12，4： | 4 |
| 3 | Diabetes, its impact on peripheral nerve regeneration: lessons from pre-clinical rat models towards nerve repair and reconstruction显示文摘The global number of patients with type 1 and type 2 diabetes is about to increase substantially in the coming decades.The reasons for this are two-fold,at first there is actual increase in incidence of type 1 diabetes and at second there is global increase in living expectancy and a high prevalence of patients with type 2 diabetes among the elderly.The diabetic condition is affiliated with reduced peripheral nervous system maintenance,such as peripheral neuropathies(Juster-Switlyk and Smith,2016)that may be more common in men. | Kirsten Haastert-Talini Lars B. Dahlin | 2018 | Neural Regeneration Research2018，13，1： | 3 |
| 4 | Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing显示文摘Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment.However,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device readings.To address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching.The resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation layers.We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption. | Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 5 | 周围神经卡压后神经元和它的反应显示文摘各种类型的周围神经损伤中,重要的是了解损伤对神经元及中枢神经系统至肢体靶器官的延伸——轴突的影响。周围神经卡压后会影响神经内大量物质的运送(轴浆流),从而引起神经胞体的形态和生化学改变。中枢的变化影响了整个轴突,并使神经对创伤的易感性增高。此文在综述双卡综合征之际研究了卡压后神经元的有关反应。 | Dahlin LB 成效敏 | 1991 | 国外医学(创伤与外科基本问题分册)1991，12，2： | 2 |
| 6 | Ulnar nerve repair by the silicon chamber technique:case report显示文摘 | DAHLIN LB DANIELSEN N | 1991 | Scand J Plast Reconslr Hand Surg1991，25，： | 1 |
| 7 | Funtional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment 显示文摘 | Haapaniemi T Nishiura Y Dahlin LB | 2002 | Peripher Nerve Syst2002，7，3： | 1 |
| 8 | Serverless Network File Systems显示文摘 | Thomas E Anderson Michael D Dahlin Jeanna M Neefe | 1996 | ACM Transactions on Computer Systems1996，14，1： | 1 |
| 9 | Improving availabihty and performance with application-specific data replication 显示文摘 | Gao L Dahlin M Nayate A | 2005 | 1EEE Transactions on Knowledge and Data Engineering2005，17，1： | 1 |
| 10 | Cutting edge : CD83 regulates the development of cellular immunity 显示文摘 | SCHOLLER N HAYDEN -LEDBETTER M DAHLIN A | 2002 | J Immunol2002，168，6： | 1 |
| 11 | Osteosarcoma of the spine显示文摘 | Shives TC Dahlin DC Sim FH | 1986 | J Bone Joint Surg Am1986，68，5： | 1 |
| 12 | Serverless network file systems显示文摘 | T Anderson M Dahlin J Neefe | 1996 | ACM Trans on Computer Systems1996，14，1： | 1 |
| 13 | 2D resistivity surveying for environmental and engineering appllcations显示文摘 | Dahlin T | 1996 | First Break1996，14，： | 1 |
| 14 | Combination of 1D laterally constrained inversion and 2D smooth inversion of resistivity data with a priori data from boreholes显示文摘 | ROGER WISEN ESBEN AUKEN TORLEIF DAHLIN | 2005 | Near Surface Geophysics2005，，： | 1 |
| 15 | Reliability and responsive- ness of three different pain assessments 显示文摘 | Lundeberg T Lund I Dahlin L | 2001 | J Rehabil Med2001，33，6： | 1 |
| 16 | Nerve regeneration in a pseudo-nerve'graft created in a silicone tube 显示文摘 | Zhao Q Lundborg G Danielsen N Bjursten LM Dahlin LB | 1997 | Brain Res1997，769，1： | 1 |
| 17 | Histologicalmorphology of the e - PTFE tissue interface in hurnanssubjectedto guided bone regeneration in conjunctionwith oral implant treatment 显示文摘 | Dahlin C Simion M Nanmark | 1998 | Clin-Dral Implants R1998，9，： | 1 |
| 18 | Carbon dioxide sequestration by direct mineral carbonation: process mineralogy of feed and products 显示文摘 | O'CONNOR W K DAHLIN D C RUSH G E | 2002 | Minerals and Metallurgical Processing2002，19，2： | 1 |
| 19 | Hyperbaric oxygen treatment hasdifferent effects on nerve regeneration in a cellular nerve and muscle grafts显示文摘 | Nishiura Y Haapaniemi T Dahlin LB | 2001 | J Peripher New Syst2001，6，2： | 1 |
| 20 | Nerve regeneration in sil-icone chambers:Influence of gap length and of distal stump com-posite显示文摘 | Lundborg G Dahlin LB Danielson N | 1982 | Exp Neurol1982，76，3： | 1 |
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