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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | A high-throughput Agrobacterium mediated transformation system for the grass model species Brachypodium distachyon L显示文摘 | Daniel I P Hans T C Klaus K N | 2008 | Transgenie Re search2008，17，： | 1 |
| 4 | Improving theper- ceptions of hotel managers 显示文摘 | Femando J G Daniel P Yeamduan N | 2008 | Annals of Tourism Research2008，35，2： | 1 |
| 5 | Block matching algorithm for motion estimation based on Artificial Bee Colony (ABC)显示文摘 | Erik Cuevas Daniel Zaldívar Marco Pérez-Cisneros Humberto Sossa Valentín Osuna | 2012 | Applied Soft Computing Journal2012，，： | 1 |
| 6 | Structure analysis of N–and O–Glycans released form glycoproteins显示文摘 | Jensen P H Karlsson N G Daniel K | 2012 | Nature Protocol2012，，12： | 1 |
| 7 | Molecular investigation of the Rh C/c polymorphism显示文摘 | Avent N D Daniels G L Martin P G | 1997 | Transfus Med1997，7，1： | 1 |
| 8 | Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase显示文摘 | ZELINSKI D P ZANTEK N D Walker - Daniels J | 2002 | J Cell Biochem2002，85，4： | 1 |
| 9 | The early diagnosis of transient osteoporosis by magnetic resonance imaging: A case report显示文摘 | DANIEL W W SANDERS P C ALARCcóN G S | 1992 | J Bone Joint Surg1992，74，8： | 1 |
| 10 | Performance prediction and its use in parallel and distributed computing systems显示文摘 | Stephen A Jarvis Daniel P Spooner Helene N Lim Choi Keung | 2006 | Future Generation Computer Systems2006，22，7： | 1 |
| 11 | Radial artery bypass graftshave an increased occurrence of angiographically severe stenosisand occlusion compared with left internal mammary arteries and sa-phenous vein grafts显示文摘 | Umesh N K Daniel T F Gosta P | 2004 | Circulation2004，109，17： | 1 |
| 12 | Multifractal analysis of soil spatial variability 显示文摘 | Adolfo N D P Daniel G Marco B | 1999 | Agronomy Journal1999，91，6： | 1 |
| 13 | Association of ST2levels with cardiac structure and function and mortality in outpa-tients 显示文摘 | DANIELS L B CLOPTON P IQBAL N | 2010 | Am Heart J2010，160，4： | 1 |
| 14 | Association of ST2 levels with cardiac structure and function and mortality in outpatients显示文摘 | DANIELS L B CLOPTON P IQBAL N | | 0，，04： | 1 |
| 15 | Isolation and characterization of mesenchymal stem cells from adult mouse bone marrow显示文摘 | Philippe T Daniele N Nadine P | 2004 | Exper Cell Res2004，295，2： | 1 |
| 16 | Use of natriuretie peptides in pre-participation screening of college athletes显示文摘 | Daniels LB Allison MA Clopton P Redwine L Siecke N Tay- lor K | 2008 | Int J Cardiol2008，124，3： | 1 |
| 17 | Miller Fisher Syndrome: 10 Years’ Experience in a Third-Level Center显示文摘 | San-juan O Daniel Martínez-herrera José Fabián Moreno García Jael Fernández Gonzalez-aragon Maricarmen Del Castillo-calcáneo Juan De Dios Pérez-neri Iván | 2009 | European Neurology2009，，3： | 1 |
| 18 | Persistent organic pollutants in edible marine species from the Gulf of Naples, Southern Italy显示文摘 | Barbara N Daniele P Maria C F | 2005 | Science of the Total Envlronmen2005，343，： | 1 |
| 19 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 20 | Case study carrying capacity in the tourism industry:A case study of Hengistbury Head显示文摘 | FERNANDO J G S YEAMDUAN N DANIEL P M | 2004 | Tourism Management2004，25，2： | 1 |
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