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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Adult attachment,social self-efficiency,self-disclosure,loneliness,and subsequent depression for freshman college student:a longitudinal study显示文摘 | Daniel W R Robyn A Z | 2005 | Journal of Counseling Psychology2005，52，4： | 1 |
| 3 | A hardware-efficient, multirate, digital channelized receiver architecture显示文摘 | DANIEL R Z DAVID L S TIMOTHY W F | 1998 | IEEE Transactions on Aerospace and Electronic Systems1998，34，1： | 1 |
| 4 | Cellular localization of gene expression for pmgrmmlin 显示文摘 | Daniel R He Z Carmichael K P | 2000 | J Histochem Cytochem2000，48，7： | 1 |
| 5 | NG2 glial cells provide a favorable substrate for growing axons显示文摘 | Yang Z Suzuki R Daniels SB | 2006 | J Neurosci2006，26，14： | 1 |
| 6 | Cellular localization of gene expression for progranulin 显示文摘 | Daniel R He Z Carmichael KP | 2000 | J Histochem Cytochem2000，48，7： | 1 |
| 7 | Parenchymal abnormalities associated with developmental venous anomalies显示文摘 | Diego San Millán Ruíz Jacqueline Delavelle Hasan Yilmaz Philippe Gailloud Enrico Piovan Alberto Bertramello Francesca Pizzini Daniel A Rüfenacht | 2007 | Neuroradiology2007，，12： | 1 |
| 8 | Cellular localization ofgene expression for progranulin显示文摘 | Daniel R He Z Carmichael K | 2000 | Histochem Cytochem2000，48，： | 1 |
| 9 | Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo显示文摘 | Daniel R L Warren R Z | 2003 | Science2003，300，： | 1 |
| 10 | Progranulin(acrogranin/PC cell derived growth factor/granulin-epithelin precursor)is expressed in the placenta,epidermis,microvasculature,and brain during murine development显示文摘 | Daniel R Daniels E He Z | 2003 | Dev Dyn2003，227，4： | 1 |
| 11 | Increasing vitamin C content of plants through enhanced ascorbate recycling 显示文摘 | Chen Z Todd E Y Ling J Chang S C Daniel R G | 2003 | Proceedings of the National Academy of Sciences of the United States of America2003，100，： | 1 |
| 12 | Effect of mater-nal dietary Restriction during Pregnancy on lamb carcass char- acteristics and muscle fiber composition显示文摘 | Daniel Z C T R Brameld J M Craigon J | 2007 | Journal of Animal Science2007，85，： | 1 |
| 13 | 妊娠期母体日粮限饲对羔羊屠体特性和肌纤维组成的影响显示文摘以前认为白肌纤维比例降低出现在妊娠第30-70天日粮限饲的母羊产下2周龄时的羔羊。两个试验旨在测定,妊娠期母体日粮限饲是否依然明显降低更老的羔羊中白肌纤维比例,以及是否影响羔羊生长率和屠体组成。在两试验中,母羊单栏饲喂,对照组在整个妊娠期间,按代谢体重(Bw0.75)推荐需要量提供营养物质;在试验1中,试验组在妊娠的第30-70天减少营养物质供应量到代谢体重推荐需要量的50%,随后恢复到对照组水平;在试验2中,试验组在妊娠的第30-85天减少营养物质供应量到代谢体重推荐需要量的50%,随后恢复到对照组水平。所有全同胞羔羊被圈在舍中,2周龄时可以出圈舍。断奶后,羔羊被单独圈养并自由采食,试验1饲养到24周龄,试验2饲养到17周龄。试验1中因为母体日粮限饲,24周龄时羔羊胴体蛋白含量降低,但不显著(P=0.18),肥肉与瘦肉比增加;试验2中母体日粮限饲对17周龄羔羊的影响不明显(P〉0.68)。母体日粮限饲对肌肉纤维类型组分几乎没有显著影响。试验1:光学显微镜下观察,快纤维数量极显著增加(P〈0.008),但慢纤维数量不受影响。试验2:光学显微镜下观察,雄性羔羊纤维总数增加,雌性羔羊中Ⅱ型(A和B)纤维增加,雄性羔羊半腱肌(ST)中ⅡB型纤维数增加。出生前肌肉分化时期母体日粮限饲可使B型肌肉纤维和肌内脂肪增加;对羔羊屠体质量的影响相对变小,但也达到显著水平。这些数据显示出2周龄羔羊适合于肌肉纤维组分的改变,这与早先观察到的相一致。然而,在本试验中羔羊出生后被很好的饲喂。如果它们出生后不能获取充足的营养,后代是否仍然能补偿,补偿失败是否影响屠体组分都有待于进一步研究。 | Daniel Z C T R Bmmeld J M Craigon J Scollan N D Buttery P J | 2007 | 饲料博览(技术版)2007，，12： | 1 |
| 14 | Arabidopsis CBF1 Overexpression Induces COR Genes and Enhances Freezing Tolerance显示文摘 | Kirsten R J O Sarah J G Daniel G Z | 1998 | Science1998，280，： | 1 |
| 15 | NG2 glial cells provide a favorable substrate for growing axons显示文摘 | Yang Z Suzuki R Daniels S B | 2006 | J Neurosci2006，26，14： | 1 |
| 16 | Cellular localization of gene expression for progranutin显示文摘 | Daniel R He Z Carmichael KP | 2000 | J Histochem Cytochem2000，48，： | 1 |
| 17 | Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development显示文摘 | Daniel R Daniels E He Z Bateman A | 2003 | Dev Dyn2003，227，： | 1 |
| 18 | Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition显示文摘 | Daniel Z C T R Brameld J M Craigon J | 2007 | Journal of Animal Science2007，85，： | 1 |
| 19 | Arabidopsis CBF1 overexpression induces cor genes and enhances freezing tolerance显示文摘 | Kirsten R J Sarach J G Daniel G Z | 1998 | Science1998，280，3： | 1 |
| 20 | Differing effects of forage and concentrate diets on the oleic acid and conjugated linoleic acid content of sheep tissues:the role of stearoyl-CoA desaturase显示文摘 | Daniel Z C T R Wyun R J Salter A M Buttery P J | | 0，，03： | 1 |
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