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| 1 | Carcinoma in situ in a 7 mm gallbladder polyp: Time to change current practice?显示文摘Detection of polypoid lesions of the gallbladder is increasing in conjunction with better imaging modalities. Accepted management of these lesions depends on their size and symptomatology. Polyps that are symptomatic and/or greater than 10 mm are generally removed, while smaller, asymptomatic polyps simply monitored. Here, a case of carcinoma-in-situ is presented in a 7 mm gallbladder polyp. A 25-year-old woman, who had undergone a routine cholecystectomy, was found to have an incidental 7 mm polyp containing carcinoma in situ. She had few to no risk factors to alert to her condition. There are few reported cases of cancer transformation in gallbladder polyps smaller than 10 mm reported in the literature. The overwhelming consensus, barring significant risk factors for cancer being present, is that such lesions should be monitored until they become symptomatic or develop signs suspicious for malignancy. In our patient's case this could have led to the possibility of missing a neoplastic lesion, which could then have gone on to develop invasive cancer. As gallbladder carcinoma is an aggressive cancer, this may have led to a tragic outcome. | David Kasle Amir A Rahnemai-Azar Shahida Bibi Vinaya Gaduputi Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 8 |
| 2 | Isolation of angiopoietin-1,a ligand for the TIE2 receptor,by secretion-trap expression cloning 显示文摘 | David S Aldrich T H Johes P F | 1996 | Cell1996，87，7： | 2 |
| 3 | Keratoconus in a patient with Alport syndrome: A case report显示文摘BACKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport syndrome.CASE SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of keratoconus.CONCLUSION Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis. | Majid Moshirfar David F Skanchy Aaron T Gomez Yasmyne C Ronquillo Benjamin Buckner Phillip C Hoopes | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 4 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 5 | Results of disc prosthesis after a minimum follow-up period of 2 years显示文摘 | David T Postacchini F | 1996 | Spine1996，21，8： | 1 |
| 6 | Mitral stenosis after mitral valve repair for non-rheumatic mitral regurgitation显示文摘 | Ibrahim M F David T E | | 0，，： | 1 |
| 7 | Laboratory meas- urement of compaction-induced permeability change in porous rocks: Implications for the generation and maintenance of pore pressure excess in the crust显示文摘 | David C Wong T F Zhu W | 1994 | Pure and Applied Geophysics1994，143，： | 1 |
| 8 | Environmentally adaptive segmentation algorithm for outdoor image segmengtation显示文摘 | Lei F T David C | 1998 | Computer and Electronics in Agriculture1998，21，3： | 1 |
| 9 | Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo显示文摘 | Hanna M Yuko F David T | 2003 | Blood2003，101，： | 1 |
| 10 | Photonic-crystal GaN light-emitting diodes with tailored guided modes distribution显示文摘 | Aurelien David Rajat Sharma T F Kelly McGroddy | 2006 | Applied Physics Letters2006，88，061124： | 1 |
| 11 | A spectral clustering method for microarray data显示文摘 | David T Shafagh F Joseph B | 2005 | Computational Statistics and Data Analysis2005，，49： | 1 |
| 12 | Multiplication and division over the dual basis显示文摘 | SEBASTIAN T J F MOHAMMED B DAVID T | 1996 | IEEE Trans on computers1996，，45： | 1 |
| 13 | Efiicient Algorithm for Optimal Fome Distribution-The Compact-Dual LP Method显示文摘 | Cheng F T Orin David E | 1990 | IEEE Transactions on Robotics and Automation1990，6，2： | 1 |
| 14 | Straus peracetic acid degradation in freshwater aquaculture systems and possible practical implications 显示文摘 | Pedersen L F Meinelt T David L | 2013 | Aquacult Eng2013，53，： | 1 |
| 15 | Behavioral and serotonergic conse- quences of decreasing or increasing hippocampus brain- derived neurotrophic factor protein levels in mice 显示文摘 | Deltheil T Guiard B P Cerdan J David D J Tanaka K F Repfirant C | 2008 | Neuropharmacology2008，55，： | 1 |
| 16 | Comparison of Total Hip Arthroplasty performed with and without cement:a randomized trial显示文摘 | Andreas L Robert B Cecil Ik David F Peter T Cindy W | 2002 | J Bone Joint Surg Am2002，84，10： | 1 |
| 17 | Using HOLSAT to evaluate tourist satisfaction at destinations:The case of Australian holi- daymakers in Vietnanl 显示文摘 | Thay H T David F | 2006 | Tourism Management2006，27，： | 1 |
| 18 | Molecular characterization of the first Austrilian isolation of Japanese encephalitis virus显示文摘 | David T Wang L F Peter W | 2000 | The FU Srain2000，81，： | 1 |
| 19 | Spatial and Tem- poral in Situ Evolution of the Concentration Profile during Casein Micelle Ultrafiltration Probed by SmaU-Angle X-ray Scattering显示文摘 | DAVID C PIGNON F NARAYANAN T | 2008 | Langmuir2008，24，： | 1 |
| 20 | Complete Quantum Tele- portation with a Kerr nonlinearity 显示文摘 | David V Mauro F Paolo T | 2000 | Physical Review Letters2000，85，： | 1 |
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