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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 4 | Bayesian network model for reliability assessment of power systems 显示文摘 | David C Y Thanh C N Peter H | 1999 | IEEE Trans on Power Systems1999，14，2： | 1 |
| 5 | The multifunctional fish gill: dominant site of gas exchange, osmoregula tion, acid-base regulation, and excretion of nitrogenous waste显示文摘 | David H Evans Peter M | 2005 | Physiol Rev2005，85，： | 1 |
| 6 | Motivated Skepticism: Use of Differential Decision Criteria for Preferred and Non - Preferred Conclusions 显示文摘 | Ditto Peter H David F Lopez | 1992 | Journal of Personality and Social Psychology1992，63，4： | 1 |
| 7 | Eigenfaces vs Fisherfaces: recognition using class specific linear projec- tion 显示文摘 | PETER N B JOAO P H DAVID J K | 1997 | IEEE Trans on Pattern Analysis and Machine In- telligence1997，19，7： | 1 |
| 8 | Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry,Vaccinium angustifolium Aiton显示文摘 | Mary H Grace David M Ribnicky Peter Kuhn | 2009 | Phytomedicine2009，16，5： | 1 |
| 9 | The production of ultrafine silica powders from silicon tetrachloride:control of the primary particle size 显示文摘 | James R H David J Peter F J | 1997 | Journal of Sol-Gel Science and echnology1997，8，1： | 1 |
| 10 | Determinants of mortality and type of repair in neonates with pulmonary atresia and intact ventricular septum显示文摘 | David A Ashburn Eugene H Blackstone Winfield J Wells Richard A Jonas Frank A Pigula Peter B Manning Gary K Lofland William G Williams Brian W McCrindle | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，4： | 1 |
| 11 | Phthalates and Perfluorooctanesulfonic Acid in Human Amniotic Fluid: Temporal Trends and Timing of Amniocentesis in Pregnancy显示文摘 | Jensen Morten S?ndergaard N?rgaard-Pedersen Bent Toft Gunnar Hougaard David M Bonde Jens Peter Cohen Arieh Thulstrup Ane Marie Ivell Richard Anand-Ivell Ravinder Lindh Christian H J?nsson Bo A G | 2012 | EN2012，，6： | 1 |
| 12 | Bayesian network model for reliability assessment of power systems 显示文摘 | David C Yu Thanh C N Peter H | 1999 | IEEE Trans on Power Systems1999，14，2： | 1 |
| 13 | Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial显示文摘 | Bryan H Burmeister B Mark Smithers Val Gebski Lara Fitzgerald R John Simes Peter Devitt Stephen Ackland David C Gotley David Joseph Jeremy Millar John North Euan T Walpole James W Denham | 2005 | Lancet Oncology2005，，9： | 1 |
| 14 | Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women显示文摘 | George W Peter T Beverley S Gordon G Joan P Nicole Z Vivian R David H Diane O Ann C | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 15 | Reporting Standards for Angioplasty and Stent-Assisted Angioplasty for Intracranial Atherosclerosis显示文摘 | H Christian Schumacher Philip M. Meyers Randall T. Higashida Colin P. Derdeyn Sean D. Lavine Gary M. Nesbit David Sacks Peter Rasmussen Lawrence R. Wechsler | 2009 | Stroke2009，，5： | 1 |
| 16 | Studies toward the large scale synthesis of the HIV proteinase inhibitor Ro 31-8959显示文摘 | Kevin E B P David J B Peter H C | 1994 | J Org Chem1994，59，13： | 1 |
| 17 | Pipe lining abrasion testing for paste backfill operations 显示文摘 | DAVID H SEBASTIAN A PETER R | 2009 | International Journal of Multiphase Flow2009，22，： | 1 |
| 18 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 19 | Towards a more plant physiological perspective on soil ecology显示文摘 | Peter H?gberg David J. Read | 2006 | Trends in Ecology & Evolution2006，，10： | 1 |
| 20 | x-Casein and the stabilization of casein inieelles显示文摘 | DAVID F WAUGH PETER H | 1956 | American Chemical Society1956，78，18： | 1 |
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