|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 3 | Interleukin - 2 sig -naling via STAT5 constrains T helper 17 cell generation显示文摘 | Laurence A Tato C M Davidson T S | 2007 | Im- munity2007，26，3： | 1 |
| 4 | The prediction of patti- cle cluster properties in the near wall region of a vertical riser显示文摘 | Harris A T Davidson J F Thorpe R B | 2002 | Powder Technology2002，127，2： | 1 |
| 5 | Towards process tomography for monitoring pressure filtration显示文摘 | York T A Davidson J L Mazurkiewich L | 2005 | IEEE Sensors Journal2005，5，2： | 1 |
| 6 | The influence of the riser exit on the particle residence time distribution in a circulating fluidised bed riser显示文摘 | Harris A T Davidson J F Thorpe R B | 2003 | Chemical Engineering Science2003，58，16： | 1 |
| 7 | Comparison of the lipid modifying efficacy and safety profiles of ezetimibe coadministered with simvastatin in older versus younger patients with primary hy- percholesterolemia: a post Hoc analysis of subpopulations from three pooled clinical trials显示文摘 | Feldman T Davidson M Shah A | 2006 | Clin Ther2006，28，6： | 1 |
| 8 | Particle residence time distributions in circulating fluidised beds显示文摘 | Harris A T Davidson J F Thorpe R B | 2003 | Chemical Engineering Science2003，58，11： | 1 |
| 9 | Interleukin - 2 signaling via STATS constrains T helper 17 cell generation显示文摘 | LAURENCE A TATO C M DAVIDSON T S | 2007 | Immunity2007，26，3： | 1 |
| 10 | Distraction with a hand-heid video game reduces pediatric preoperative anxiety显示文摘 | Pate1 A Schieble T Davidson M | 2006 | Paediatric Anesthesia2006，16，10： | 1 |
| 11 | SF-FDG-PET/CT for the diagnosis of tumor thrombosis显示文摘 | Davidson T Goitein O Avigdor A | 2009 | Isr Med Assoc J2009，11，2： | 1 |
| 12 | Taxonomic or ecological approachea? searching for phytoplartktort surrogates in the determination of richness and assemblage composition in ponds 显示文摘 | GALLEGO I DAVIDSON T A JEPPESEN E | 2012 | Ecological Indicators2012，18，： | 1 |
| 13 | Effects of soil water content on soil respiration in forests and cattle pastures of eastern Amazonia 显示文摘 | Davidson E A Verchot L V Cattanio J/-t | 2000 | Biogeochemistry2000，48，： | 1 |
| 14 | Flexible codebook de- sign for limited feedback systems via sequential smooth optimization on the Grassmannian manifold 显示文摘 | MEDRA A DAVIDSON T N | 2014 | IEEE Transactions on Signal Processing2014，62，5： | 1 |
| 15 | Resu- lts of the national cholesterol education (NCEP)program evaluation project utilizing novel e-technology (NEPTUNE) II survey and implications for treatment under the recent NCEP Writing Group recommendations 显示文摘 | DAVIDSON M H MAKI K C PEARSON T A | 2005 | Am J Cardiol2005，96，4： | 1 |
| 16 | Retinoic acid inhibits Thl7 polarization and enhances FoxP3 expression through a Stat -3/Stat -5 independent signaling Pathway 显示文摘 | Elias K M Laurence A Davidson T S | 2008 | Blood2008，111，3： | 1 |
| 17 | Parti- cle residence time distributions in circulating fluidized beds 显示文摘 | HARRIS A T DAVIDSON J F THORPE R B | 2003 | Chemical Engineering Science2003，58，： | 1 |
| 18 | Comparison of the lipid- modifying efficacy and safety profiles of ezetimibe coadministered with simvastatin in older versus younger patients with primary hypercholesterolemia: a post Hoc analysis of subpopulations from three pooled clinical trials 显示文摘 | Feldman T Davidson M Shah A | 2006 | Clin Ther2006，28，6： | 1 |
| 19 | The prediction of particle cluster properties in the near wall region of a vertical riser显示文摘 | Harris A T Davidson J F Thorpe R B | | 0，，02： | 1 |
| 20 | Distraction with a hand-held video game reduces pediatric preoperative anxiety显示文摘 | Patel A Schieble T Davidson M | 2006 | Paediatr Anaesth2006，16，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员