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| 1 | Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-KB pathway显示文摘 | Zong-chao LIU Zhen-long WANG Chen-yi HUANG Zhi-jiang FU Yong LIU Zhang-chao WEI Shi-gui LIU Chuan MA Jie-liang SHEN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，6： | 29 |
| 2 | The CIC-3 chloride channels in cardiovascular disease显示文摘 | Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 26 |
| 3 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 4 | Fangjiomics: revealing adaptive omics pharmacological mechanisms of the myriad combination therapies to achieve personalized medicine显示文摘 | Dayue Darrel DUAN Zhong WANG Bo-li ZHANG Yong-yan WANG | 2015 | Acta Pharmacologica Sinica2015，36，6： | 11 |
| 5 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 6 | 药物表型组学:药理毒理学和个体化医学的新模式(英文)显示文摘近年来,药物基因组学(pharmacogenomics)研究收集了大量有关遗传多态性对药物反应(疗效和毒性反应)的普遍影响的信息,并突出显示了基因组指导下的个体化药物治疗的必要性。然而,由于疾病和药物治疗临床效果和毒性反应的内在复杂性,并且往往涉及数十个或数百个基因和环境因素的动态变化的影响,将药物基因组学的知识转化为个体化医学的临床实践面临着重大的挑战和障碍。为了克服这些障碍,些包括药物蛋白质组学(pharmacoproteomics)和药物代谢组学(pharmacometabolomics)等在内的新学科应运而生。同时,这些'组学'研究也揭示了在越来越详细的基因组/蛋白质组学/代谢组学的变异性与目前定义的各种临床疾病和药物治疗表型的复杂性之间存在着种非平行关系。因而要种新的研究模式来重新定义这种表型与基因组/蛋白质组/代谢组之间的非平行关系。此文将介绍个跨领域的新学科,它能为从只注重于单纯的表型-基因型关系的研究模式转化到系统性的表型组-基因组关系的研究方法提供整套新的技术平台,从而在系统生物学水平重新定义具有整合性的药物治疗靶点群,改进药物研究的模式,使其更适合于临床个体化医学与药物治疗。这个新学科就是'药物表型组学(pharmacophenomics)'。表型组(phenome)是在特定环境影响下有机体基因组/蛋白质组/代谢组表达的整体表型特征的总和。表型组学(phenomics)则是对表型组与基因组/转录组(transcritome)/蛋白质组/代谢组/相互作用组(interactome)和环境因素变化之间的复杂关系的定量研究。药物表型组学将系统性地确定对应于定义明确的疾病表型组的综合性药物靶标群。因此,药物表型组学将与药物基因组学、药物蛋白质组学组学和药物代谢组学等学科互补,为药物作用和毒性的研究提供个革命性的新模式。 | Dayue Darrel DUAN 韩业山 李立 赵建中 王忠 | 2014 | 中国药理学与毒理学杂志2014，28，1： | 10 |
| 7 | Tumor exosomes: a double-edged sword in cancer therapy显示文摘肿瘤房间比正常房间生产并且藏匿更多的 nucleic 酸,蛋白质和类脂化合物。这些分子在包含膜的 exosomes 在血或在房间附近被搬运。导出肿瘤或联系肿瘤的 exosomes (通常在直径的 30-100 nm ) 包含与为涉及癌症的致病,发展,前进,和转移的细胞间的通讯表明送信人一起父母房间类似于那些的丰富的生物内容。当这些 exosomes 能从各种各样的身体液体被检测并且孤立,他们为癌症的诊断和预后成为了吸引人的新 biomarkers。而且,肿瘤 exosomes 也为癌症的治疗由于他们的潜在的同样新奇的治疗学的策略吸引了增加的注意。在一方面,包含膜的泡正在答应药和指向特定的癌症房间的另外的治疗学的材料的搬运人的类脂化合物 bilayer。在另一方面,肿瘤 exosomes 是为象 chemoresistance 一样安排对癌症房间的生长和转移批评的事件的微型环境的调整的重要调停人。这里,我们在最近的年里在我们联系肿瘤或导出肿瘤的 exosomes 的理解总结进展,并且更重要地在癌症的癌症开发,前进,侵略,和转移并且,讨论他们的角色,他们在为各种各样的癌症以及重要警告的精确治疗的策略的潜力。 | Wei SUN Ju-dong LUO Hua JIANG Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 9 |
| 8 | 一种简捷可靠的小鼠气管插管新方法显示文摘目的探索一种安全、高效的小鼠气管插管新方法。方法这种新方法是在小鼠颈前作一小切口,显露气管后,经口腔作气管内插管,费时仅约1 m in。结果经过1300多次实验,无一例失败,成功率达100%。结论这种简捷实用、安全可靠的小鼠气管插管新方法无需特殊设备及体位,一人操作即能完成,可显著提高以小鼠为实验动物模型的成功率。 | 刘利辉 叶玲玉 谭渊明 刘昭前 William Hatton Dayue Duan | 2006 | 中国医师杂志2006，8，8： | 9 |
| 9 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 10 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 11 | Chloride channels in stroke显示文摘脉管包括脉管的光滑的肌肉房间(VSMC ) 的增长,移植,和 apoptosis,服的小动脉改变在大脑是在动脉和血流动或出血的突然的打断的代表性的区域和直径的变化的主要原因,即,中风。积累的证据强烈为氯化物支持一个重要角色(在脉管的改变和击的 Cl −) 隧道。至少三 Cl − 隧道基因在 VSMC 被表示:1 ) TMEM16A (或 Ano1 ) ,它可以编码激活钙的 Cl − 隧道(CACC ) ;2 ) CLC-3 Cl − 隧道和 Cl −/H+ antiporter,它是仔细与调整卷的 Cl − 隧道(VRCC ) 有关;并且 3 ) 膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 它编码激活 PKA 、激活 PKC 的 Cl − 隧道。由细胞内部的 Ca 2+ 的导致收缩筋的增加的 CACC 的激活引起 VSMC 的膜去极,血管缩小,和抑制增长。由房间体积增加或膜段的 VRCC 的激活支持反应的氧种类的生产,导致增长并且禁止 VSMC 的 apoptosis。CFTR 的激活禁止氧化应力并且可以阻止高血压的发展。另外, Cl − 电流由 gamma-aminobutyric 酸(伽马氨基丁酸) 调停了受体也被含有在 ischemic 神经原死亡的一个角色。这评论在中风的发展集中于 Cl − 隧道的功能的角色并且在未来方向上提供一个观点让研究和潜力为中风的预防和治疗作为新目标开发 Cl − 隧道。 | Ya-ping ZHANG Hao ZHANG Dayue Darrel DUAN | 2013 | Acta Pharmacologica Sinica2013，34，1： | 8 |
| 12 | Effects of drought stress on photosynthesis and chlorophyll fluorescence images of soybean(Glycine max)seedlings显示文摘The main purpose of this research is to provide a theoretical foundation for the screening of drought-resistant soybean varieties and to establish an efficient method to detect the PSII actual photochemical quantum yields efficiently.Three soybean varieties were compared in this experiment after 15 d when they were planted in a greenhouse.These varieties were then exposed to light drought stress(LD)and serious drought stress(SD)conditions.With five times’measurement,chlorophyll fluorescence and soil-plant analysis development considered as the main basis for this study.Several parameters in SD conditions significantly reduced,such as net photosynthetic rates(Pn),stomatal conductance(Gs),PSII primary light energy conversion efficiency(Fv/FM),PSII actual photochemical quantum yields[Y(II)],photochemical quenching coefficient(qP)and non-photochemical quenching coefficient(qN).The soybeans in the seedling stage adapted to the inhibitory effect of drought stress on photosynthesis through stomatal limitation.Under serious drought stress,non-stomatal limitation damaged the plant photosynthetic system.The amplitudes of Pn and Y(II)of drought-resistant Qihuang 35 were lower than those of the two other varieties.Based on the data of this study,a new method had been developed to detect Y(II)which reflected the photosynthetic capacity of plant,R=0.85989,u=0.048803 when using multiple linear regression,and R=0.84285,u=0.054739 when using partial least square regression. | Wensen Wang Cheng Wang Dayu Pan Yakun Zhang Bin Luo Jianwei Ji | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 7 |
| 13 | Genome evolution trend of common carp (Cyprinus carpio L.) as revealed by the analysis of microsatellite loci in a gynogentic family显示文摘Genome evolution arises from two main ways of duplication and reduction. Fish specific genome duplication (FSGD) may have occurred before the radiation of the teleosts. Common carp (Cyprinus carpio L.) has been considered to be a tetraploid species, because of its chromosome numbers (2n=100) and its high DNA content. Using 69 microsatellite primer pairs, the variations were studied to better understand the genome evolution (genome duplication and diploidization) of common carp from a gynogenetic family. About 48% of primer pairs were estimated to amplify duplicates based on the number of PCR amplification per individual. Segregation patterns in the family suggested a partially duplicated genome structure and disomic inheritance. This indicates that the common carp is tetraploid and polyploidy occurred by allotetraploidy. Two primer pairs (HLJ021 and HLJ332) were estimated to amplify reduction based on the number of PCR amplification per individual. One allele in HLJ002 locus and HLJ332 locus was clearly lost in the gynogenetic family and the same as in six wild populations. Segregation patterns in the family suggested a partially diplodization genome structure. A hypothesis transition (dynamic) and equilibrium (static) were proposed to explain the common carp genome evolution between genome duplication and diploidization. | Yah Zhang Liqun Liang Peng Jiang Dayu Li Cuiyun Lu Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，2： | 7 |
| 14 | Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation显示文摘Thymosin 贝它 4 (T4 ) ,涉及愈合弯屈的多种的扣押肌动朊的多肽和发展过程,被报导了强烈与 tumorigenesis 被联系。最近的组织 microarray 分析证明 T4 高度在某些肿瘤房间被表示,包括肺癌症。然而,准确表示模式和在非小的房间肺癌症(NSCLC ) 的 T4 的角色有不我们的知识调查。在现在的学习,我们证实那 T4 表情在 NSCLC 纸巾和房间线被增加。在 A549 和 H1299 房间的 T4 基因 silencing 在 vitro 禁止了房间增长,移植,和侵略并且减少在 vivo 的肿瘤生长。机械学的调查在 T4 基因沉默房间在 Notch1 激活揭示了重要减少。而且,恢复 Notch1 表达式在 NSCLC 房间稀释了 T4 silencing 的函数。一起拿,这些调查结果建议 T4 可以在 NSCLC 前进起一个 oncogenic 作用并且可以是为 anti-NSCLC 的一个新奇分子的目标治疗。 | Dayu Huang ShaohuaWang An Wang Xiaofeng Chen Huijun Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 15 | Geochemical characteristics and tectonic setting of the Tuerkubantao mafic-ultramafic intrusion in West Junggar,Xinjiang,China显示文摘Mineral chemistry,whole-rock major oxide,and trace element compositions have been determined for the Tuerkubantao mafic-ultramafic intrusion,in order to understand the early Paleozoic tectonic evolution of the West Junggar orogenic belt at the southern margin of the Central Asian orogenic belt.The Tuerkubantao mafic-ultramafic intrusion is a well-differentiated complex comprising peridotite,olivine pyroxenite,gabbro,and diorite.The ultramafic rocks are mostly seen in the central part of the intrusion and surrounded by mafic rocks.The Tuerkubantao intrusive rocks are characterized by enrichment of large ion lithophile elements and depleted high field strength elements relative to N-MORB.In addition,the Tuerkubantao intrusion displays relatively low Th/U and Nb/U(1.13—2.98 and 2.53—7.02,respectively) and high La/Nb and Ba/Nb(1.15—4.19 and 37.7—79.82,respectively).These features indicate that the primary magma of the intrusion was derived from partial melting of a previously metasomatized mantle source in a subduction setting.The trace element patterns of peridotites,gabbros,and diorite in the Tuerkubantao intrusion have sub-parallel trends,suggesting that the different rock types are related to each other by differentiation of the same primary magma.The intrusive contact between peridotite and gabbro clearly suggest that the Tuerkubantao is not a fragment of an ophiolite.However,the Tuerkubantao intrusion displays many similarities with Alaskan-type mafic-ultramafic intrusions along major sutures of Phanerozoic orogenic belts.Common features include their geodynamic setting,internal lithological zoning,and geochemistry.The striking similarities indicate that the middle Devonian Tuerkubantao intrusion likely formed in a subduction-related setting similar to that of the Alaskan-type intrusions.In combination with the Devonian magmatism and porphyry mineralization,we propose that subduction of the oceanic slab has widely existed in the expansive oceans during the Devonian around the Junggar block. | Yufeng Deng Feng Yuan Taofa Zhou Chao Xu Dayu Zhang Xuji Guo | 2015 | Geoscience Frontiers2015，6，2： | 4 |
| 16 | New omic and network paradigms for deep understanding of therapeutic mechanisms for Fangji of traditional Chinese medicine显示文摘 | Dayue Darrel DUAN Zhong WANG Yong-yan WANG | 2018 | Acta Pharmacologica Sinica2018，39，6： | 4 |
| 17 | Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives显示文摘The novel severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and an ongoing severe pandemic.Curative drugs specific for COVID-19 are currently lacking.Chloroquine phosphate and its derivative hydroxychloroquine,which have been used in the treatment and prevention of malaria and autoimmune diseases for decades,were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.Therefore,chloroquine phosphate was first used in the treatment of COVID-19 in China.Later,under a limited emergencyuse authorizati on from the FDA,hydroxychloro quine in combi nation with azithromyci n was used to treat COVID-19 patie nts in the USA,although the mechanisms of the anti-COVID-19 effects remain unclear.Preliminary outcomes from clinical trials in several countries have gen erated con troversial results.The desperatio n to control the pan demic overrode the con cerns regardi ng the serious adverse effects of chloro quine derivatives and combi nation drugs,i ncluding lethal arrhythmias and cardiomyopathy.The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease.While respiratory symptoms are the major clin ical man ifestati ons,cardiovascular abno rmalities,in eluding arrhythmias,myocarditis,heart failure,and ischemic stroke,have been reported in a significant number of COVID-19 patients.Patients with preexisting cardiovascular conditions(hypertension,arrhythmias,etc.)are at increased risk of severe COVID-19 and death.From pharmacological and cardiovascular perspectives,therefore,the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated,and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. | Xiao-lei Zhang Zhuo-ming Li Jian-tao Ye Ji ng Lu Lingyu Linda Ye Chun-xiang Zhang Pei-qing Liu Dayue D Duan | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 18 | Epidemiological Characteristics of Plague in the Meriones unguiculatus Plague Focus--Inner Mongolia Autonomous Region,China,1950−2019显示文摘From 1950 to 2019,a total of 267 plague cases in humans were reported in the Inner Mongolia Autonomous Region with 133 deaths and 10,710 Yersinia pestis isolates;21 of these cases were reported from the Meriones unguiculatus(M.unguiculatus)plague focus with 6 deaths and 6,771 isolates.According to the plague situation in the Inner Mongolia Autonomous Region and the implementation of local preventive measures,the prevalence of plague in humans in the M.unguiculatus plague focus of the Inner Mongolia Autonomous Region could be divided into four stages.The first stage was the initial stage of plague prevention and control(1950–1959),with 0.80 cases annually and a case fatality rate of 37.50%.The second stage was the plague eradication stage(1960–1979),with 0.15 cases annually and a case fatality rate of 33.33%.The third stage was the plague surveillance stage(1980-1999),with 0.25 cases annually and a case fatality rate of 20.00%.The fourth stage is the comprehensive prevention and control stage under the emergency system(2000-2019),with 0.25 cases annually and a case fatality rate of 20.00%.The surveillance of rodent density(1981-2019)and studies on plague-related factors among M.unguiculatus have shown that the higher the M.unguiculatus density,the higher the nocturnal rodent capture rate(r=0.670,p<0.05)and the higher the indirect hemagglutination assay(IHA)positive rate of M.unguiculatus(r=0.344,p<0.05);the higher the percentage of hosts infected,the lower the M.unguiculatus density(r=-0.361,p<0.05)and the lower the IHA positive rate of M.unguiculatus(r=-0.337,p<0.05);the higher the percentage of nests infected with fleas,the lower the IHA positive rate of M.unguiculatus(r=-0.348,p<0.05).Together,these results suggest that it is necessary to simultaneously monitor the pathogens,serology,and vector index of M.unguiculatus to accurately reflect the plague prevalence among local animals.Although bubonic plague is the main plague type of the M.unguiculatus plague focus,severe pneumonic plague or septic plague may be secondary when the bubonic plague is misdiagnosed or not treated in time.In addition,the plague in animals is relatively virulent in the M.unguiculatus plague focus,and the risk of spreading to humans is higher.For plague in the Inner Mongolia Autonomous Region,comprehensive control efforts should be aimed at the M.unguiculatus focus,covering host animals,vector insects,and humans. | Boxi Liu Dayu Zhang Yuhuang Chen Zhaokai He Jun Liu Dongyue Lyu Weiwei Wu Ran Duan Shuai Qin Junrong Liang Huaiqi Jing Xin Wang | 2020 | China CDC weekly2020，2，49： | 3 |
| 19 | Underwater Object Recognition Based on Deep Encoding-Decoding Network显示文摘Ocean underwater exploration is a part of oceanography that investigates the physical and biological conditions for scientific and commercial purposes. And video technology plays an important role and is extensively applied for underwater environment observation. Different from the conventional methods, video technology explores the underwater ecosystem continuously and non-invasively. However, due to the scattering and attenuation of light transport in the water, complex noise distribution and lowlight condition cause challenges for underwater video applications including object detection and recognition. In this paper, we propose a new deep encoding-decoding convolutional architecture for underwater object recognition. It uses the deep encoding-decoding network for extracting the discriminative features from the noisy low-light underwater images. To create the deconvolutional layers for classification, we apply the deconvolution kernel with a matched feature map, instead of full connection, to solve the problem of dimension disaster and low accuracy. Moreover, we introduce data augmentation and transfer learning technologies to solve the problem of data starvation. For experiments, we investigated the public datasets with our proposed method and the state-of-the-art methods. The results show that our work achieves significant accuracy. This work provides new underwater technologies applied for ocean exploration. | WANG Xinhua OUYANG Jihong LI Dayu ZHANG Guang | 2019 | Journal of Ocean University of China2019，18，2： | 3 |
| 20 | Effect of xanthan gum on the quality of low sodium salted beef and property of myofibril proteins显示文摘The effects of xanthan gum (0 % and 0.3 %) on the quality of low sodium (2.0 %, 2.4 %, 2.8 %, 3.2 %, 3.6 % and 4.0 %) salted beef and property of myofibril proteins (MP) extracted from salted beef were researched. Changes in the salting absorptivity, cooking loss, shear force, color and sensory analysis showed that xanthan gum had a positive effect on the quality of salted beef with low salinity (2.0 %, 2.4 % and 2.8 %). MP of salted beef treated with xanthan gum had higher solubility, lower hydrogen bond than that without it (P < 0.05). The decrease of surface hydrophobicity and intrinsic fluorescence intensity indicated that the chromophore of protein was brought into a hydrophobic environment in the presence of xanthan gum. The electrophoresis showed that xanthan gum could improve the concentration of myosin heavy chain, paramyosin and actin after tumble-salting. The data suggested that salted beef and its MP treated with xanthan gum and 2.8 % salt (XS3) had the best properties. Together, xanthan gum could be considered as a sodium salt substitute for the development of low sodium meat products. | Zirui Zhao Shujie Wang Dayu Li Yajun Zhou | 2021 | Food Science and Human Wellness2021，10，1： | 3 |
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