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| 1 | Model-Based Integrated Methods for Quantitative Estimation of Soil Salinity from Hyperspectral Remote Sensing Data:A Case Study of Selected South African Soils显示文摘Soil salinization is a land degradation process that leads to reduced agricultural yields. This study investigated the method that can best predict electrical conductivity (EC) in dry soils using individual bands, a normalized difference salinity index (NDSI), partial least squares regression (PLSR), and bagging PLSR. Soil spectral reflectance of dried, ground, and sieved soil samples containing varying amounts of EC was measured using an ASD FieldSpec spectrometer in a darkroom. Predictive models were computed using a training dataset. An independent validation dataset was used to validate the models. The results showed that good predictions could be made based on bagging PLSR using first derivative reflectance (validation R2 = 0.85), PLSR using untransformed reflectance (validation R2 = 0.70), NDSI (validation R2 = 0.65), and the untransformed individual band at 2257 nm (validation R2 = 0.60) predictive models. These suggested the potential of mapping soil salinity using airborne and/or satellite hyperspectral data during dry seasons. | Z. E. MASHIMBYE M. A. CHO J. P. NELL W. P. DE CLERCQ A. VAN NIEKERK D. P. TURNER | 2012 | Pedosphere2012，22，5： | 29 |
| 2 | 传感器、集成和电源管理的进步推动可穿戴技术的发展显示文摘'第三代'可穿戴设备将会集成更多的生物传感器,在功耗上也会有进一步的提高,其电池将会有更持久的续航能力;安全方面也在不断增强,Dialog在其针对可穿戴设备技术的解决方案中采用了加密技术,确保用户数据的安全;而且,未来的可穿戴设备将不局限于只戴于手腕上,人体的许多部位都将可佩带可穿戴设备。 | Mark de Clercq | 2016 | 电子产品世界2016，23，5： | 9 |
| 3 | Anti-HIV Ⅰ/Ⅱ Activity and Molecular Cloning of a Novel Mannose/Sialic Acidbinding Lectin from Rhizome of Polygonatum cyrtonema Hua显示文摘 | Jie AN Jin-Zhi LIU Chuan-Fang WU Jian LI Lei DAI Els Van DAMME Jan BALZARINI Erik De CLERCQ Fang CHEN Jin-Ku BAO | 2006 | Acta Biochimica et Biophysica Sinica2006，38，2： | 8 |
| 4 | Approved HIV reverse transcriptase inhibitors in the past decade显示文摘HIV reverse transcriptase(RT)inhibitors are the important components of highly active antiretroviral therapies(HAARTs)for anti-HIV treatment and pre-exposure prophylaxis in clinical practice.Many RT inhibitors and their combination regimens have been approved in the past ten years,but a review on their drug discovery,pharmacology,and clinical efficacy is lacking.Here,we provide a comprehensive review of RT inhibitors(tenofovir alafenamide,rilpivirine,doravirine,dapivirine,azvudine and elsulfavirine)approved in the past decade,regarding their drug discovery,pharmacology,and clinical efficacy in randomized controlled trials.Novel RT inhibitors such as islatravir,MK-8504,MK-8507,MK8583,IQP-0528,and MIV-150 will be also highlighted.Future development may focus on the new generation of novel antiretroviral inhibitors with higher bioavailability,longer elimination half-life,more favorable side-effect profiles,fewer drug–drug interactions,and higher activities against circulating drug-resistant strains. | Guangdi Li Yali Wang Erik De Clercq | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 5 | Interactive Study between Two Types of 1-[2-(Hydroxyethoxy)methyl] -6-naphthylmethylthymines and HIV-1 Reverse Transcriptase显示文摘Two different types of 1-[2-(hydroxyethoxy)methyl]-6-naphthylmethylthymines have been designed, synthesized and evaluated for their anti-HIV-1 activities in different cells lines. The binding free energy (DG) including steric and electrostatic between the two different ligands and reverse transcriptase Non-Nucleoside Binding Pocket (NNBP) have been docked and calculated to evaluate their accommodation circumstance on a SGI work station. The DG and anti-HIV-1 activity has been correlated in order to guide further drug design, which showed that the steric binding effect dominated in the whole binding action between the compounds and reverse transcriptase (RT). The results showed that more negative DG led to higher activity of compounds. | 孟歌 陈芬儿 De Clercq Erik 戴惠芳 | 2003 | 过程工程学报2003，3，1： | 4 |
| 6 | An Odyssey in antiviral drug development—50 years at the Rega Institute:1964–2014显示文摘I.How it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of Prof.Piet De Somer,then professor of microbiology at the Leuven School of Medicine.When I graduated | Erik De Clercq | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 2 |
| 7 | S-DAPYs类似物的分子设计、合成及抑制HIV-1的活性研究显示文摘我们以已上市的etravirine和正在临床研究的VRX-480773两个逆转录酶抑制剂为模板,通过杂交这两个化合物的药效团,获得含酰胺片段的S—DAPYs类似物,该类似物对野生型HIV-1病毒株具有中等强度抑制活性.而Maurizio所发现的另一类无酰胺片段的S.DAPYs类似物却表现出优异的抑制活性.为了考察酰胺片段对S-DAPYs类似物抑制HIV-1活性的影响,本文合成了一系列无酰胺片段的S—DAPYs类似物.生物活性结果表明,3个化合物(6g、6m和6s)对野生型HIV-1具有中等强度抑制活性(EC50在6.5~15.4μmol/L范围内),弱于相应的具有酰胺片段的类似物.此外,分子模拟还揭示了酰胺片段可与K103形成至关重要的氢键作用,这为新型非核苷类逆转录酶抑制剂的设计奠定了理论基础. | 万正勇 陈芬儿 Erik De Clercq Dirk Daelemans Christophe Pannecouque | 2015 | 中国科学:化学2015，45，9： | 2 |
| 8 | Eggs of Ephestia kuehniella and Ceratitis capitata, and motile stages of the astigmatid mites Tyrophagus putrescentiae and Carpoglyphus lactis as factitious foods for Orius spp.显示文摘几虚假食物为饲养 anthocorid 食肉动物 Orius thripoborus (Hesse ) 和 Orius naivashae (Poppius ) 被估计(半翅类:Anthocoridae ) 在实验室。当提供了地中海面粉蛾的冻结的鸡蛋时,两 Orius 种的发展、繁殖的特点被检验, Ephestia kuehniella Zeller,冻结的处理鸡蛋 medfly, Ceratitis capitata Wiedemann,或 astigmatid 螨 Tyrophagus putrescentiae (Schrank ) 或 Carpoglyphus lactis (L) 的混合能动阶段。而 C。lactis 和 T。putresecentiae 证明了是为饲养 O 的劣等的食物。thripoborus 和 O。naivashae, C 的鸡蛋。capitata 充分支持了两个食肉动物的开发和复制。结果在上 medfly 鸡蛋类似于 E 上的那些或稍微劣等。kuehniella 鸡蛋,它是为 culturing 的标准食物这些 anthocorid 臭虫。O。thripoborus 能在 C 上为 4 连续的代被维持。capitata 鸡蛋显示那 medfly 处理了鸡蛋能是 E 的一种合适、更便宜的选择。为这些 Orius spp 高耸延长的 kuehniella 鸡蛋。 | Jochem Bonte Anais Van de Walle Des Conlong Patrick De Clercq | 2017 | Insect Science2017，24，4： | 2 |
| 9 | The potential of trehalose to replace insect hemolymph in artificial media for Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae)显示文摘昆虫添加剂被显示了改进 Trichogramma 种类的人工的媒介的值,但是同时在主机昆虫的平行文化上维持依赖。在现在的学习, Trichogramma dendrolimi Matsumura 在人工的媒介上从鸡蛋在 vitro 被饲养到成年人与中国橡树 silkmoth Antheraea pernyi 的蛹的 hemolymph 的不同内容(Gu 湩琠敨朠晩吗?? | Xin Lu Shi-Chou Han Li-Ying Li Simon Grenier Patrick De Clercq | 2013 | Insect Science2013，20，5： | 2 |
| 10 | Fitness and predation potential of Macrolophus pygmaeus reared under artificial conditions显示文摘在当植物材料不在时高耸延长以后的 Macrolophus pygmaeus Rambur 的生物参数与通常饲养植物的食肉动物的那些相比。当 Ephestia kuehniella Zeller 的鸡蛋作为食物被提供时, M 的发展、繁殖的健康。用人工的生活和 oviposition 底层为超过 30 连续的代饲养的 pygmaeus 类似于坚持的食肉动物的烟草叶子。饲养 Plantless 食肉动物的第五中间形态也在烟草蚜虫的第二中间形态上有类似的 predation 率, Myzus persicae nicotianae Blackman,他们在植物材料上维持的同伴。在一个进一步的实验,由第五中间形态 M 的蚜虫猎物上的 predation。pygmaeus 喂了二个鸡蛋之一基于蛋黄的人工的食谱与美女的相比喂的 E。kuehniella 鸡蛋。尽管有他们的更低的身体重量,当他们的对应物在鳞翅类的卵上高耸了,食肉动物在人工的饮食杀死了的任何一个上生产了猎物的类似的数字。我们的学习显示人工的高耸系统可能是有用的进一步文饰这个经济地重要的生物控制代理人的生产。 | Bjorn Vandekerkhove Veronic De Puysseleyr Maarten Bonte Patrick De Clercq | 2011 | Insect Science2011，18，6： | 2 |
| 11 | Vegetation change detection using artificial neural networks with ancillary data in Xishuangbanna,Yunnan Province,China显示文摘地球的及时、精确的变化察觉“ s 表面特征为更好计划,管理和环境研究提供基础。在这个学习 ANN 变化,察觉被用来执行植被变化察觉,并且与分类以后的方法相比。以前分类以后被执行 ANN 分类被用来产出多时间的植被地图。ANN 也被用来在 2003 和 2004 为图象执行一个一个通行证分类。DEM 和斜坡被用作二条额外的隧道。在训练阶段期间,训练数据包括 36 个变化子类和 46 个没有变化子类被分开成 82 个子类。而且 NDVI differencing 方法被用来开发变化面具。当鉴别参考区域能为 ANN 那个生产更精确的变化察觉结果时,结果显示出那把 NDVI differencing 方法与视觉解释相结合通行证变化分类。而且,和 PCA 部件把举起和斜坡用作额外的隧道是有效的,在多山的学习区域执行基于 ANN 的变化察觉。把植被转变类分开成子类基于也是重要的光谱反应模式,特别为多山的地面。这个处理能减少地志的效果并且改进变化察觉精确性。 | ZHANG ZhiMing Lieven VERBEKE Eva De CLERCQ OU XiaoKun Robert De WULF | 2007 | Chinese Science Bulletin2007，52，A02： | 2 |
| 12 | 非核苷类逆转录酶抑制剂的研究XVⅢ:4-烯丙基和4-叠氮基取代的三嗪类化合物的合成及抗HIV活性(英文)显示文摘在已有工作基础上,基于分子对接设计合成了8个新的4-烯丙基取代和4-叠氮基取代的二芳基三嗪类衍生物。抗HIV-1活性的测试结果表明所有新化合物均具有抗HIV-1活性。其中化合物7c不仅抑制HIV-1野生株的复制(IC50=0.034μmol·L-1,SI=6475),且对Y181C和K103C双突变酶显示出较强的抑制活性,其IC50值为9.39μmol·L-1,高于奈韦拉平。 | 熊远珍 胡海荣 陈芬儿 Jan Balzarini Christophe Pannecouque Erik De Clercq | 2009 | 药学学报2009，44，2： | 2 |
| 13 | Evolutionarily conserved role of nucleostemin:controlling proliferation of stem/progenitor cells during early vertebrate development显示文摘 | Nichane M De Clercq S | 2006 | Mol Cell Biol2006，26，24： | 1 |
| 14 | Reproducfive failure in sows following experimental infection with a Belgian EMCV isolate显示文摘 | KOENEN F DE CLERCQ K LEFEBVRE J | 1994 | Vet Microbio11994，39，12： | 1 |
| 15 | Effects of Relational Capital and Com- mitment on Venture Capitalists ' Perception of Portfolio Company Performance 显示文摘 | De Clercq D Sapienza H J | 2006 | Journal of Business Venturing2006，21，3： | 1 |
| 16 | Biomechanical analysis of the stance phase during barefoot and shod running显示文摘 | De Wit B De Clercq D Aerts P | | 0，，： | 1 |
| 17 | Biomechanical analysis of the stance phase during barefoot and shod running显示文摘 | De Wit B De Clercq D Aerts P | | 0，，： | 1 |
| 18 | Current drug research on PEGylation with small molecular agents显示文摘 | Wenjun Li Peng Zhan Erik De Clercq | 2013 | Progress in Polymer Science2013，38，34： | 1 |
| 19 | Development of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors:Boosting the safety and metabolic stability显示文摘Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1(EC_(50)=1.0 nmol/L),but the poor metabolic stability in human liver microsomes(t_(1/2)=14.6 min)and insufficient selectivity(SI=2059)with high cytotoxicity(CC_(50)=2.08μmol/L)remained major issues associated with JK-4b.The present efforts were devoted to the introduction of fluorine into the biphenyl ring of JK-4b,leading to the discovery of a novel series of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines with noticeable inhibitory activity toward WT HIV-1 strain(EC_(50)=1.8–349 nmol/L).The best compound 5t in this collection(EC_(50)=1.8 nmol/L,CC_(50)=117μmol/L)was 32-fold in selectivity(SI=66,443)compared to JK-4b and showed remarkable potency toward clinically multiple mutant strains,such as L100I,K103N,E138K,and Y181C.The metabolic stability of 5t was also significantly improved(t_(1/2)=74.52 min),approximately 5-fold higher than JK-4b in human liver microsomes(t_(1/2)=14.6 min).Also,5t possessed good stability in both human and monkey plasma.No significant in vitro inhibition effect toward CYP enzyme and hERG was observed.The single-dose acute toxicity test did not induce mice death or obvious pathological damage.These findings pave the way for further development of 5t as a drug candidate. | Xin Jin Shuai Wang Limin Zhao Wenjuan Huang Yinxiang Zhang Christophe Pannecouque Erik De Clercq Ge Meng Huri Piao Fener Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 20 | Anti - human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6 - substituted acyclouridine derivatives显示文摘 | BABA M DE CLERCQ E LIDA S | 1990 | Antimicrob Agent Chemother1990，34，： | 1 |
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