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| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | Silicon carbide resonant tuning fork for microsensing applications in high-temperature and high G-shock environments显示文摘We present the fabrication and testing of a silicon carbide(SiC)balanced mass double-ended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth.The device features a material stack that survives corrosive environments and enables high-temperature operation.To perform high-temperature testing,a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics.The tuning fork has been operated at 600 ℃ in the presence of dry steam for short durations.This tuning fork has also been tested to 64 000 G using a hard-launch,soft-catch shock implemented with a light gas gun.However,the device still has a strain sensitivity of 66 Hz/με and strain resolution of 0.045 με in a 10 kHz bandwidth.As such,this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges,accelerometers,gyroscopes,and pressure transducers.Given the adaptable fabrication process flow,this device could be useful to micro-electro-mechanical systems(MEMS) designers creating sensors for a variety of different applications. | David R Myers Kan Bun Cheng Babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu B J Wijesundara Albert P Pisano | 2012 | Engineering Sciences2012，10，5： | 6 |
| 3 | Fibre and soluble phenolic monomer composition of morphological components of sorghum stover显示文摘 | Debbie J R Cherney J J | 1991 | Journal of the Science of Food and Agriculture1991，54，4： | 1 |
| 4 | Preparation and properties of the succinic ester of porous starch显示文摘 | Peter R C Qian D Y Debbie P A | 2012 | Carbohydrate Polymers2012，88，2： | 1 |
| 5 | Vanadate tetramer as the inhibiting species in enzyme reactions in vitro and in vivo显示文摘 | Debbie C C Ellen M W Steven R B | | 0，，： | 1 |
| 6 | ESTs, cDNA microarray, and gene expression profiling : tools for dissecting plant physiology and development显示文摘 | AIBA R FEI Z J PAYTON P LIU Y MOORE S L DEBBIE P COHN J D'ASCENZO M GORDON J S JOCELYN K C ROSE MARTIN G TANKSLEY S D BOUZAYEN M JAHN M M GIOVANNONI J | 2004 | Plant Journal2004，39，5： | 1 |
| 7 | Modelling tacit knowledge via questionnaire data显示文摘 | PETER B DEBBIE R | 2004 | Lecture Notes in Computer Science2004，2961，： | 1 |
| 8 | Row spacing, plant density, and nitrogen effects on corn silage 显示文摘 | William J Cox Debbie J R Cherney | 2001 | Agronomy Journal2001，93，： | 1 |
| 9 | Online monitoring of voltage stability margin using an artificial neural network显示文摘 | DEBBIE Q Z ANNAKKAGE U D ATHULA D R | 2010 | IEEE Transactions on Power Systems2010，25，3： | 1 |
| 10 | Association of C- Reactive Protein With Blood Pressure and ypertension显示文摘 | George Davey Smith Debbie A Lawlor R | 2005 | Artefioselerosis Thrombosis and Vascular Biology2005，25，： | 1 |
| 11 | Fibre and soluble phe- nolic monomer composition of morphological compo- nents of sorghum stover显示文摘 | Debbie J R Cherney J A P J | 1991 | Journal of the Science of Food and Agriculture1991，54，4： | 1 |
| 12 | Laparoscopic surgery for extrauterine pregnancy in hemodynamically unstable patients 显示文摘 | Sagiv R Debby A Sadan O | 2001 | J Am Assoc Gynecol Laparosc2001，8，4： | 1 |
| 13 | The impact of glycemic control on neonatal outcome in single- ton pregnancies complicated by gestational diabetes显示文摘 | GONZALEZ - QUINTERO V H ISTWAN N B DEBBIE J R | 2007 | Diabetes Care2007，30，3： | 1 |
| 14 | American Cancer So- ciety guideline for the early detection of cervical neoplasia and cancer显示文摘 | Debbie S Carolyn D R Diane S | 2002 | Cancer J Clin2002，52，： | 1 |
| 15 | American cancer society guideline for the early detectionof cervical neopJasia and cancer显示文摘 | DEBBIE S CAROLYN D R DIANE S | 2003 | J Lower Genital Tract Dis2003，7，2： | 1 |
| 16 | Litter decomposition and nitrogen mineralization of soils in subtropical plantation forests of southern china,with special attention to comparisons between legumes and non-legumes显示文摘 | Li Z A Peng S L Debbie J R | 2001 | Plant and Soil2001，229，： | 1 |
| 17 | Row spacing, plant density, and nitrogen effects on corn silage显示文摘 | William J Cox Debbie J R Chemey | 2001 | Agronomy Journal2001，93，： | 1 |
| 18 | TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia显示文摘 | Kramer D Steenbergen R D Debbie Kramer | 2004 | J Nat Cancer Inst2004，96，4： | 1 |
| 19 | Sensory characteristics of five sweet potato eultivars and their changes during storage under tropical conditions显示文摘 | QUIRIEN E A OIRSCHOT V DEBBIE R | 2003 | Food Quality and Preference2003，，14： | 1 |
| 20 | Fibre and soluble phenolic monomer composition of morphological components of sorghum stover显示文摘 | Debbie J R Cherney J A P J | 1991 | Journal of the Science of Food and Agriculture1991，54，4： | 1 |
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