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| 1 | Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer,therapeutic treatment options for platinum-resistant ovarian cancer显示文摘The survival rates for women with ovarian cancer have shown scant improvement in recent years,with a 5-year survival rate of less than 40%for women diagnosed with advanced ovarian cancer.High-grade serous ovarian cancer(HGSOC)is the most lethal subtype where the majority of women develop recurrent disease and chemotherapy resistance,despite over 70%-80%of patients initially responding to platinum-based chemotherapy.The phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signaling pathway regulates many vital processes such as cell growth,survival and metabolism.However,this pathway is frequently dysregulated in cancers including different subtypes of ovarian cancer,through amplification or somatic mutations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),amplification of AKT isoforms,or deletion or inactivation of PTEN.Further evidence indicates a role for the PI3K/AKT/mTOR pathway in the development of chemotherapy resistance in ovarian cancer.Thus,targeting key nodes of the PI3K/AKT/mTOR pathway is a potential therapeutic prospect.In this review,we outline dysregulation of PI3K signaling in ovarian cancer,with a particular emphasis on HGSOC and platinum-resistant disease.We review pre-clinical evidence for inhibitors of the main components of the PI3K pathway and highlight past,current and upcoming trials in ovarian cancers for different inhibitors of the pathway.Whilst no inhibitors of the PI3K/AKT/mTOR pathway have thus far advanced to the clinic for the treatment of ovarian cancer,several promising compounds which have the potential to restore platinum sensitivity and improve clinical outcomes for patients are under evaluation and in various phases of clinical trials. | Natasha Rinne Elizabeth LChristie Anastasia Ardasheva Chun Hei Kwok Nikita Demchenko Caroline Low Catherine Tralau-Stewart Christina Fotopoulou Paula Cunnea | 2021 | Cancer Drug Resistance2021，4，3： | 3 |
| 2 | 科研信息化基础设施的大数据挑战显示文摘首先探讨大数据科学(Big Data Science)给现代和未来科研数据基础设施(SDI)带来的挑战,并参考不同科研团体的工作对数据管理、访问控制和安全要求进行定义,然后介绍科研数据生命周期管理(SDLM)模型,分析所有的主要阶段,反映现代e—Science的数据管理特性,提出SDI通用架构模型,为利用现代技术和最佳实践构建以互用性数据或项目为中心的SDI奠定了基础,最后对如何利用基于云的现代基础设施服务配置模型顺利实现文中提出的SDLM和SDI模型进行阐述,解决SDI资源的联合访问控制问题,为科研团体提供了一种灵活的访问控制和身份管理模型。 | Demchenko Yuri Zhao Zhiming Grosso Paola Wibisono Adianto de Laat Cees | 2013 | 中国科技资源导刊2013，45，1： | 3 |
| 3 | Rapid cerebral schemic preconditioning in mice deficient in endothelial and euronal nitric oxide synthases 显示文摘 | Atochin DN Clark J Demchenko IT | 2003 | Stroke2003，34，5： | 1 |
| 4 | Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity显示文摘 | Allen BW Demchenko IT Piantadosi CA | 2009 | J Appl Physiol2009，106，2： | 1 |
| 5 | Site-selective excitation:a new dimen-sion in protein and membrane spectroscopy显示文摘 | Demchenko A P | 1988 | Trends in Biochemical Sci1988，13，10： | 1 |
| 6 | Structure of the pseudedecagonal Al-Co-Ni approximant PD4显示文摘 | Oleynikov P Demchenko L Christensen J | 2006 | Philosophical Magazine2006，86，： | 1 |
| 7 | Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases 显示文摘 | Atochin DN Clark J Demchenko IT | 2003 | Stroke2003，34，5： | 1 |
| 8 | Electrochromie modulation of excited-state intramolecular proton transfer: the new principle in design of fluorescence sensors显示文摘 | Klymchenko A S Demchenko A P | 2002 | Journal of zhe American Chemical Society2002，124，12： | 1 |
| 9 | A method for optimization of time intervals between rolling cuts on sorting humps显示文摘Sorting humps are the main technical means providing the breaking-and making-up of freight trains.Automation of sorting process by implementing microprocessor control systems is the main direction of increasing hump yard capacity, enhancement of safety in trains breaking-up, improvement of working conditions on hump yards. However, for wider introduction of such systems at the humps, it is necessary to reduce their cost.One of the main tasks of hump control systems is the determination of the optimal cars exit speeds from the retarders. Its solution is significantly complicated because of the uncertainty of cars rolling resistance coefficient,wind velocity and direction, retarder control errors. The paper is aimed at solving the problem of searching for such cars exit speeds from the retarders that provide the longest time intervals between them at the switches. Implementation of this method will make it possible to improve the quality of sorting process as a whole by improving the software of microprocessor control systems for automatic humping, rather than by increasing their technical facilities,which as a result will reduce the cost of their construction and operation. The research results, when solving the problem of searching for cars exit speeds from the retarders, allow us to move from searching for the maximum of a nonlinear non-smooth function of two variables to solution of an equation with one variable, which significantly accelerates and simplifies the solution to the problem. | Dmytro Kozachenko Volodymyr Bobrovsky Yevhen Demchenko | 2018 | Journal of Modern Transportation2018，26，3： | 1 |
| 10 | Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure 显示文摘 | Demchenko IT Luchakow YI Moskvin AN | 2005 | J Cereb Blood Flow Metab2005，25，10： | 1 |
| 11 | Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric 3xide synthases 显示文摘 | Atochin DN Clark J Demchenko IT | 2003 | Stroke2003，34，5： | 1 |
| 12 | Two faces of nitric ox- ide: implications for cellular mechanisms of oxygen toxicity 显示文摘 | Allen B W Demchenko I T Piantadosi C A | 2009 | J Appl Physiol2009，106，2： | 1 |
| 13 | Spontaneous superlattice formation in nanorods through partial cation exchange显示文摘 | ROBINSON R D SADTLER B DEMCHENKO D O | | 0，，5836： | 1 |
| 14 | Optical properties of ZnO/ZnS and ZnO/ZnTe heterostructures forphotovoltaic applications 显示文摘 | Schrier J Demchenko D O Wang L W | 2007 | Nano Lett2007，7，8： | 1 |
| 15 | Kinetics of thelactate dehydrogenase reaction in high - viscosity media 显示文摘 | Demchenko AP Ruskyn 01 Saburova EA | 1989 | Biochim Biophys Acta1989，998，： | 1 |
| 16 | Regulation of the brain's vascular responses to oxygen显示文摘 | Demchenko I T | 2002 | Circ Res2002，91，11： | 1 |
| 17 | Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia 显示文摘 | Atochin DN Demchenko IT Astern J | 2003 | J Cereb Blood Flow Metab2003，23，10： | 1 |
| 18 | Fre- quent engagement o the classical and alternative NF-KBpathways by diverse genetic abnormalities in muhiple myeloma显示文摘 | Annunziata CM Davis RE Demchenko Y | 2007 | Cancer Cell2007，12，2： | 1 |
| 19 | Beyond annexin V: fluorescence response of cellularmembranes to apoptosis显示文摘 | Demchenko A P | 2013 | Cytotechnology2013，65，2： | 1 |
| 20 | Rapid cerebralischemic preconditioning in mice deficient in endothelial andneuronal nitric oxide synthases显示文摘 | Atochin DN Clark J Demchenko IT | 2003 | Stroke:a journal of cerebralcirculation2003，34，： | 1 |
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