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| 1 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 2 | Pathophysiology and treatment of Barrett's esophagus显示文摘Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared. | Daniel S Oh Steven R DeMeester | 2010 | World Journal of Gastroenterology2010，16，30： | 2 |
| 3 | DNA methylation: an alternative pathway to cancer 显示文摘 | Wajed S A Laird P W DeMeester T R | 2001 | Ann Surg2001，234，： | 1 |
| 4 | Preoperative lower esophageal sphincter pressure affects outcome of laparoscopic esophageal myotomy for achalasia显示文摘 | Mustafa A Arain Jeffrey H Peters Anan P Tamhankar Giuseppe Portale Gideon Almogy Steven R DeMeester Peter F Crookes Jeffrey A Hagen Cedric G Bremner Tom R DeMeester | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 5 | Maintaining the silence:reflections on long-term RNAi显示文摘 | Raemdonck K Vandenbroucke R E Demeester J | 2008 | Drug Discovery Today2008，13，2122： | 1 |
| 6 | Pore sizes in hydrated dextran microspheres 显示文摘 | STENEKES R J De Smedt S C DEMEESTER J | 2000 | Biomacromolecule2000，，1： | 1 |
| 7 | Preoperative diagnosis of lymph node metastasis: a dream? 显示文摘 | LIPHAM J C DEMEESTER T R | 2006 | Gastric Cancer2006，9，2： | 1 |
| 8 | Three-dimensional pressure image and muscular structure of the human lower esophageal sphincter显示文摘 | Hubert J. Stein Dorothea Liebermann-Meffert Tom R. DeMeester J. Rüdiger Siewert | 1995 | Surgery1995，，6： | 1 |
| 9 | Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles 显示文摘 | VANDENBROUCKE R E LENTACKER I DEMEESTER J | 2008 | J Controlled Release2008，126，3： | 1 |
| 10 | Vagal -spar- ing esophagectomy : a more physiologic alternative 显示文摘 | BANK! F MASON R J DEMEESTER S R | 2002 | Ann Surg2002，236，3： | 1 |
| 11 | Development of the 24 hour intraesophageal pH monitoring composite scoring system显示文摘 | Johnson L F DeMeester T R | 1986 | J Clin Gastroenterol1986，8，1： | 1 |
| 12 | Adenocarcinoma of the esophagus and cardia:a review of the disease and itstreatment显示文摘 | Steven R DeMeester A | 2005 | Ann Surg Oncol2005，13，1： | 1 |
| 13 | Concertration of refluxed acid and esophageal mucosal injury显示文摘 | BREMNER R M CROOKES R F DEMEESTER T R | 1992 | Am J Surg1992，164，： | 1 |
| 14 | Adenocarcinoma of the esophagus and cardia: a review of the disease and its treatment显示文摘 | DeMeester S R | 2006 | Ann Surg Oncol2006，13，1： | 1 |
| 15 | Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles显示文摘 | Vandenbroucke R E Lentacker I Demeester J | 2008 | J Control Release2008，126，3： | 1 |
| 16 | Serum creatinekinase levels in overt and subclinical hypothyroidism显示文摘 | Beyer IW Karmali R Demeester - Mirkine N | 1998 | Thyroid1998，8，： | 1 |
| 17 | The significance of p53 in clinical practice显示文摘 | Ireland A P Clark G W B DeMeester T R | 1997 | Ann Surg1997，225，1： | 1 |
| 18 | Development of the 24 hour intraesophageal pH monitoring composite scoring system显示文摘 | JOHNSON L F DEMEESTER T R | 1986 | J Clin Gastroenterol1986，8，1： | 1 |
| 19 | Importance of duodenogastfic reflux in the surgical outpa-tientpraetice 显示文摘 | Mason R J DeMeester TR | 1999 | I-Iepatogastmenterology1999，46，25： | 1 |
| 20 | Clinical characteristics,biologic behavior,and survival after esophagectomy are similar for adenocarcinoma of the gastroesophageal junction and the distal esophagus显示文摘 | Leers J M DeMeester S R Chan N | 2009 | J Thorac Cardiovasc Surg2009，138，3： | 1 |
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