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| 1 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 2 | 大别山双河和碧溪岭超高压变质岩流体包裹体研究显示文摘对大别山双河和碧溪岭含柯石英榴辉岩和硬玉石英岩进行了详细的流体包裹体研究。根据流体包裹体的成分和盐度的不同 ,可以划分出至少五种类型不同的气液包裹体 :( 1) N2 包裹体 ;( 2 )高盐度流体包裹体 ;( 3) CO2 包裹体 ;( 4) CO2 -H2 O包裹体 ;( 5 )低盐度流体包裹体。N2 包裹体仅见于含柯石英榴辉岩 ,而高盐度流体包裹体则几乎存在于所有的榴辉岩和硬玉石英岩中。 CO2 包裹体沿榴辉岩中微剪切带分布 ,或存在于强变形的硬玉石英岩中 ,而低盐度流体包裹体分布较为局限。N2 和高盐度流体被认为是超高压变质作用平衡的产物 ,来源于变质前的古孔隙流体。而且榴辉岩中含有一系列盐度不同的流体显微域 ,其大小与矿物颗粒相当。在板块折返过程中 ,包裹体中流体可能发生迁移 ,但是不会超出寄主晶体的范围。CO2流体明显是外来的 ,可能来自共生大理岩或含碳酸盐的变质沉积岩。这与菱镁矿和柯石英等共生组合所指示的进变质过程中大理岩不存在脱碳反应的结论相一致。而低盐度流体则可能系顶峰变质矿物分解而成 。 | 傅斌 肖益林 J L R Touret A M Van den Kerkhof JHoefs 郑永飞 | 2000 | 岩石学报2000，16，1： | 14 |
| 3 | Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver显示文摘AIM: To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS: Fifty-four adult male Wistar rats were randomly divided into three groups: A normal control (NC) group, a partial hepatectomized (PH) group and a sham operated (SO) group. To study the effect of liver regeneration on BMP-2 expression, rats were sacrificed before and at different time points after PH or the sham intervention (6, 12, 24 and 48 h). For each time point, six rats were used in parallel. Expression and distribution of BMP-2 protein were determined in regenerating liver tissue by Western blot analysis and immunohistochemistry. Effects of BMP-2 on cell proliferation of human Huh7 hepatoma cell line were assessed using an MTT assay.RESULTS: In the normal liver strong BMP-2 expression was observed around the central and portal veins. The expression of BMP-2 decreased rapidly as measured by both immunohistochemistry and Western blot analysis. This decrease was at a maximum of 3.22 fold after 12 h and returned to normal levels at 48 h after PH. No significant changes in BMP-2 immunoreactivity were observed in the SO group. BMP-2 inhibited serum induced Huh7 cell proliferation.CONCLUSION: BMP-2 is expressed in normal adult rat liver and negatively regulates hepatocyte proliferation. The observed down regulation of BMP-2 following partial hepatectomy suggests that such down regulation may be necessary for hepatocyte proliferation. | Cui-Ping Xu Wen-Min Ji Gijs R van den Brink Maikel P Peppelenbosch | 2006 | World Journal of Gastroenterology2006，12，47： | 10 |
| 4 | 高通气综合征?还是惊恐障碍?显示文摘 | 韩江娜 R Schepers K Stegen O Van den Bergh KP Van de Woestijne | 2001 | 中华结核和呼吸杂志2001，24，9： | 9 |
| 5 | Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis显示文摘 | Herbrecht R Denning DW Patterson TF | | 0，，： | 2 |
| 6 | Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/v-Al2O3 catalyst显示文摘 | R W von den Brink R Louw P Mulder | 1998 | Applied Catalysis B:Environmental1998，16，： | 2 |
| 7 | CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice显示文摘 | Medina-Contreras Oscar Geem Duke Laur Oskar Williams Ifor R Lira Sergio A Nusrat Asma Parkos Charles A Denning Timothy L | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 8 | 难加工材料的铣削和钻削加工显示文摘当前,减轻飞机重量这一目标正在促使航空航天工业采用越来越多的特种材料,如复合材料、钛合金和铬镍铁合金。相比普通材料,此类材料重量更轻、强度更高,但在加工方面,特别是铣削和钻削方面,它们各自拥有不同的加工难题。 | Teun Van Asten Wilco van den Boogaard Pr Nordberg | 2013 | 航空制造技术2013，56，14： | 2 |
| 9 | Effect of 1,2-propanediol and dimethylsulphoxide on the meiotic spindle of the mouse oocytes显示文摘 | Van der Elst J van den Abbeel E Jacobs R | 1988 | Hum Reprod1988，3，： | 2 |
| 10 | A multi-centre obser- vational study on the efficacy of Dicural Palatabs (difloxacin) for the treatment of canine cystitis 显示文摘 | van den Hoven R | 1997 | J Vet Pharmacol Therap1997，20，1： | 2 |
| 11 | Prophylactic isradipine treatment after kidney transplantation:a prospective double-blind placebo-controlled randomized trial显示文摘 | van den Dorpel MA Zietse R Ijzermans JN | 1994 | Transpl Int1994，71，： | 2 |
| 12 | Experimental and theoretical study of the swirling flow in centrifugal compressor volute显示文摘 | Van den Braembussche R A Hand B M | 1990 | ASME Journal of Turbornachinery1990，112，3： | 2 |
| 13 | Site of triggering of the accommodation reflex in man显示文摘 | Van den Berghe PD Vos R Janssens J | 2000 | Gastroenterology2000，114，： | 1 |
| 14 | Imaging and management of head and neck paragangliomas显示文摘 | van den Berg R | 2005 | Eur Radiol2005，15，7： | 1 |
| 15 | Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion显示文摘 | MORELAND LW ALTEN R van den BOSCH F l | 2002 | Arthritis Rheum2002，46，6： | 1 |
| 16 | Measuring mechanical properties of coating: a methodology applied to nano-particlefilled sol-gel coating on glass显示文摘 | MALZBENDER J DEN TOONDER J M J BALKENENDE A R | 2002 | Mater Sei Eng R2002，36，： | 1 |
| 17 | Toll-like receptor 2 controls expansion and function of regulatory T cells显示文摘 | Sutmuller R P den Brok M H Kramer M | 2006 | J Clin Invest2006，116，2： | 1 |
| 18 | Identification of the oxidation products of the reaction between ct-pinene and hydroxyl radicals by gas and high-performance liquid chromatography with mass spectrome- tric detection显示文摘 | van den BERGH V VANHEES I DE BOER R | | Journal of Chromatography A0，896，12： | 1 |
| 19 | Radiotherapy plusconcomitant and adjuvant temozolomide for glioblastoma显示文摘 | Stupp R Mason WP van den Bent MJ | 2005 | NEngl J Med2005，352，10： | 1 |
| 20 | Development of a combined new mechanical and enzymatic method for the isolation of intact preantral follicles from fetal calf and adult bovine ovaries 显示文摘 | FIGUEIREDO J R HULSHOF S C J VAN DEN HURK R | 1993 | Theriogenology1993，40，： | 1 |
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