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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of solution heat treatment on galvanic coupling be-tween intermetallics and matrix in AA7075-T6显示文摘 | ANDREATTA F TERRYN H DEWIT J H W | 2003 | Corrosion Science2003，45，： | 1 |
| 3 | Indentification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulvum as β-1,3-glucanse and chitinase显示文摘 | Joosten M H Dewit P J | 1989 | Plant Physiol1989，89，： | 1 |
| 4 | Target volumes in radiotherapy for high-grade malig- nant glioma of the brain 显示文摘 | JANSEN E P M DEWIT L G H VAN HERK M | 2000 | Radiotherapy and Oncolo- gy2000，56，2： | 1 |
| 5 | Spatial characterization of drought events using synthetic hydrology 显示文摘 | Burn D H DeWit W J | 1996 | Canadian Journal of Civil Engineering1996，23，6： | 1 |
| 6 | A geometric model of alternating current etching of aluminum显示文摘 | Dewit H J Boots H M J | 1983 | J Appl Phys1983，，5： | 1 |
| 7 | Molecular characterization of the human excision repair gene ERCC-I:cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10显示文摘 | van DuinM deWit J Odijk H | 1986 | Cell1986，44，： | 1 |
| 8 | Molecular characterization of the human excision repair gene ERCC-1:cDNA cloning and a-mino acid homology with the yeast DNA repair gene RAD10显示文摘 | Van-Duin M Dewit J Odijk H | 1986 | Cell1986，44，6： | 1 |
| 9 | Identification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulyam as β-1,3-glucanse and chitinase显示文摘 | Joostem M H Dewit P J | 1989 | Plant Physio11989，89，3： | 1 |
| 10 | Friction models and friction compensation 显示文摘 | Olsson H ~strtim K J deWit C C | 1998 | European Journal of Control1998，4，3： | 1 |
| 11 | Identification of several pathogenesis-related proteins in tomato leaves inoculated with Cladosporium fulvum as 1,3-b-glucanases and chitinases显示文摘 | Dewit P J G M | 1989 | Plant Physiol1989，89，： | 1 |
| 12 | EIS measurements on artificial blisters in organic coatings显示文摘 | VANDER W D H VANWESTING E P M DEWIT J H W | | 0，，： | 1 |
| 13 | An o18 tracer study on the oxidation mechanism of alumina scales on NiAl and NiAl-alloys 显示文摘 | YOUNG E W A DEWIT J H W | 1986 | Oxid Met1986，26，56： | 1 |
| 14 | A new model for control of systems with friction 显示文摘 | Canudas deWit C Olsson H A strom K J | 1995 | IEEE Transactions on Automatic Control1995，40，3： | 1 |
| 15 | The use of an O18 tracer and Rutherford back scattering spectrometry to study the oxidation mechanism of NiAl显示文摘 | Dewit J H W | 1985 | Solid State Ionics1985，16，： | 1 |
| 16 | Malignant sdwannoma with a rhabdomyoblastic component,a so called triton tumor, A Clinicopathologic study显示文摘 | Dewit L Albus Lutter C E De Jone A S H | 1986 | Cancer1986，58，： | 1 |
| 17 | A survey of models,analysis tools and compensation methods for the control of machines with friction显示文摘 | Armstrong H B Dupont P Canudas DeWit C | 1994 | Automatica1994，30，7： | 1 |
| 18 | A geometric model of alternating currentetching of aluminum显示文摘 | DEWIT H J BOOTS H M J | 1983 | J Appl Phys1983，，5： | 1 |
| 19 | Simultaneous integrated boost- intensity modulated radiation therapy with concomitant capecitabine and mitomycinc for locally advanced anal earcinoma:a phase 1 study 显示文摘 | Deenen M J Dewit L Boot H | 2013 | Int J Radiat Oncol Biol Phys2013，85，5： | 1 |
| 20 | 1-α,25-Dihydroxyvitamin D3(1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes显示文摘 | Canning MO Grotenhuis K DeWit H | 2001 | Eur J Endocrinol2001，145，3： | 1 |
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