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| 1 | Bone Regeneration Based on Tissue Engineering Conceptions – A 21st Century Perspective显示文摘The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades.Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction.However,improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity.Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.Specifically,novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment,whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue.Future generations of biomaterials(third generation)are designed to be not only osteoconductive but also osteoinductive,i.e.to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications.These techniques will lead to novel possibilities for tissue regeneration and repair.At present,tissue engineered constructs that may find future use as bone grafts for complex skeletal defects,whether from post-traumatic,degenerative,neoplastic or congenital/developmental'origin'require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells,scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties.This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts. | Jan Henkel Maria A.Woodruff Devakara R.Epari Roland Steck Vaida Glatt Ian C.Dickinson Peter F.M.Choong Michael A.Schuetz Dietmar W.Hutmacher | 2013 | Bone Research2013，1，3： | 33 |
| 2 | Antioxidants,inflammation and cardiovascular disease显示文摘Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite(ONOO-) is formed solely in the presence of superoxide anion(O2-). Neopterin and kynurenine to tryptophan ratio(Kyn/Trp),as an estimate of IDO enzyme activity,are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise,a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C,-E and-B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites,BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD. | Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner | 2014 | World Journal of Cardiology2014，6，6： | 25 |
| 3 | 德国生态城市Erlangen显示文摘Erlangen城座落在德国南部,是著名的生态城市,文章通过对该城市生态建设的实践说明:公众如果能得到有关指导,他们都是乐于解决生态问题并做出有益于环境的举措的。 | Dietmar Hahlweg | 2003 | 规划师2003，19，1： | 19 |
| 4 | Plant Sucrose Transporters from a Biophysical Point of View显示文摘更高的植物使用蔗糖的多数作为他们的主要活动糖类。质子驱动的蔗糖 transporters 玩在 cell-to-cell 和在整个植物的蔗糖的长途的分发的一个关键角色。一个很否定的植物膜潜力和蔗糖 transporters 到的能力积累超过 1 的蔗糖集中 ? M 显示植物与唯一的结构、功能的特征发展了 transporters。然而,运输机制和这些 nano 机器的结构 / 功能的领域的知识是仍然碎片的。在这评论,植物蔗糖 transporters 的生物物理的性质的当前的知识被总结并且讨论。 | Dietmar Geiger | 2011 | Molecular Plant2011，4，3： | 17 |
| 5 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 6 | 磷化氢及其氧化产物动态释放对铜绿微囊藻(Microcystis aeruginosa)生长的影响显示文摘就磷化氢释放对铜绿微囊藻的生长进行了研究.采用藻类生长潜力试验(AGP)的方法,研究了磷化氢及其氧化产物亚磷酸盐、次亚磷酸盐对水华暴发优势藻类(铜绿微囊藻)的生长的影响,结果表明:磷化氢及其氧化产物对铜绿微囊藻的生长有重要的影响.富营养水体磷化氢的释放可能在引起湖泊水华暴发中起到了重要的作用. | 牛晓君 张景飞 史小丽 王晓蓉 高光 季江 Dietmar Glindemann | 2003 | 湖泊科学2003，15，3： | 13 |
| 7 | 全球大停电的经验教训显示文摘根据国际能源机构的预测,在未来20多年里,发展中国家和新兴国家的耗电量将增加220%,而工业化国家则仅增加37%。现有电力系统负荷的大幅度增加将产生瓶颈效应和可靠性问题。历年发生的欧美州大停电清楚地表明,相邻系统间的紧密电气耦合对于重负荷互联系统而言,可能存在无法控制的级联事故风险。介绍美加大停电和欧洲大停电事件,讨论大停电的经验教训。对避免环流、防止电压崩溃等解决大型电力系统稳定性问题的措施及“防火墙”的实施进行了说明。阐述涉及系统改善的高压直流输电(HVDC)和灵活交流输电(FACTS)技术的优点。 | Gǖnther Beck Dusan Povh Dietmar Retzmann Erwin Tehsch | 2007 | 中国电力2007，40，10： | 11 |
| 8 | BRAIN INJURY BIOMECHANICS IN REAL WORLD VEHICLE ACCIDENT USING MATHEMATICAL MODELS显示文摘This paper aims at investigating brain injury mechanisms and predicting head injuries in real world accidents. For this purpose, a 3D human head finite element model (HBM-head) was developed based on head-brain anatomy. The HBM head model was validated with two experimental tests. Then the head finite element(FE) model and a multi-body system (MBS) model were used to carry out reconstructions of real world vehicle-pedestrian accidents and brain injuries. The MBS models were used for calculating the head impact conditions in vehicle impacts. The HBM-head model was used for calculating the injury related physical parameters, such as intracranial pressure, stress, and strain. The calculated intracranial pressure and strain distribution were correlated w/th the injury outcomes observed from accidents. It is shown that this model can predict the intracranial biomechanical response and calculate the injury related physical parameters. The head FE model has good biofidelity and will be a valuable tool for the study of injury mechanisms and the tolerance level of the brain. | YANG Jikuang XU Wei OTTE Dietmar | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 10 |
| 9 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 10 | Subsidence history and forming mechanism of anomalous tectonic subsidence in the Bozhong depression, Bohaiwan basin显示文摘The Bozhong depression of the Bohaiwan basin belongs to a family of extensional basins in East China, but is quite different from other parts of the basin. The Cenozoic subsidence of the depression is controlled by a combination of lithospheric thinning and polycyclic strike-slip movements. Three episodic rifts have been identified, i.e. Paleocence-early Eocene, middle-late Eocene and Oligocene age. The depression underwent syn-rift and post-rift stages, but two episodic dextral movement events of the strike-slip faults modify the subsidence of the Bozhong depression since the Oligocene. The early dextral movement of the Tan-Lu fault associated with crustal extension resulted in accelerated subsidence during the time of deposition of the Dongying Formation with a maximum thickness of 4000 m. A late reactivation of dextral movement of the Tan-Lu fault began in late Miocene (about 12 Ma), which resulted in the intense subsidence of Minghuazhen Formation and Quaternary. In addition, dynamic mantle convection-driven topography also accelerated the post-rift anomalous subsidence since the Miocene (24.6 Ma). Our results indicate that the primary control on rapid subsidence both during the rift and post-rift stages in the Bozhong depression originates from a combination of multiple episodic crustal extension and polycyclic dextral movements of strike-slip faults, and dynamic topography. | MüLLER R. Dietmar | 2007 | Science China Earth Sciences2007，50，9： | 8 |
| 11 | 特高压直流输电设备设计综述(英文)显示文摘高压直流输电已发展成为成熟的技术,典型的电压等级为±500kV。在中国正在运行的几个直流系统中,单条直流系统完整双极的输送容量已达3GW。同时,还有几个电压等级为800kV的UHVDC系统正在建设中,并计划从2009年中期开始陆续投入商业营运。在±800kV直流运行电压基础上,随着通电流能力的不断增加,直流系统的输电能力将会达到双极7.2GW的输送容量。电力技术的长足进步,有赖于强有力的HVDC换流站设备设计的研发工作和长期以来积累的设备制造经验。文章总结了设备设计技术攻关方面的难点,并介绍了UHVDC换流站设备技术的现实情况。 | Marcus Haeusler Dietmar Retzmann | 2008 | 南方电网技术2008，2，4： | 8 |
| 12 | 结合态磷化氢在污水深度处理系统中的源显示文摘 | 丁丽丽 梁瀚文 朱益新 莫伟恒 王强 任洪强 王晓蓉 Marc Edwards Dietmar Glindemann | 2005 | 科学通报2005，50，10： | 8 |
| 13 | 微血管减压术治疗原发性三叉神经痛显示文摘目的提出微血管减压术是治疗原发性三叉神经痛的最佳手术方式。方法报告了12例原发性三叉神经痛患者行微血管减压术,其中11例发现三叉神经入脑干区动脉压迫神经根,将压迫血管与神经根分离,在其间植入纤维蛋白海绵或聚四氟乙烯片维持分离状态,术后除1例疼痛减轻外,其余疼痛完全缓解,另1例术中未发现责任血管,但在神经根远侧段发现有粘连,将粘连松解,使神经根游离。结果所有患者术后疼痛减轻或缓解,所有病例无并发症。结论微血管减压术治疗原发性三叉神经痛是去除病因的手术方式,对已行微血管减压术后复发的患者再次行微血管减压术亦可获得满意疗效,作者还认为,神经内镜辅助微血管减压术顺应了当今微侵袭外科的趋势,将有望被更多地用来治疗原发性三叉神经痛。 | 黄元奎 Dietmar Stolke | 2006 | 中华神经外科疾病研究杂志2006，5，1： | 7 |
| 14 | 经颅修补及颅底重建治疗外伤性脑脊液鼻漏(附2例报告)显示文摘目的探讨经颅修补及颅底重建手术在治疗外伤性脑脊液鼻漏中的有效性和价值。方法分析2例典型外伤性脑脊液鼻漏病人的手术治疗,均经影像学检查和鼻分泌物Beta-2转铁蛋白实验确诊。其中1例存在右侧筛板骨折,部分塌陷;另1例存在额窦内壁及框顶部分缺损。均行经颅修补及颅底重建手术,术中用略大于漏口的颅骨膜片修补漏口,再用肌肉筋膜覆盖其上,涂以生物胶,颅底及额窦内壁用相应大小的钛网重建并固定,以恢复颅底及颅腔正常解剖结构。结果病人脑脊液鼻漏停止,术后未发生感染和脑膜膨出,随访1个月未见复发。结论对于合并存在较大颅底缺损的外伤性脑脊液鼻漏病人,经颅修补及颅底重建是彻底治愈脑脊液鼻漏的有效手术方式。 | 黄元奎 金保山 陈涛 Dietmar Stolke | 2005 | 中国微侵袭神经外科杂志2005，10，3： | 7 |
| 15 | Multiple Calcium-Dependent Kinases Modulate ABA-Activated Guard Cell Anion Channels显示文摘 | Sonke Scherzer Tobias Maierhofer Khaled A.S. Al-Rasheid Dietmar Geiger Rainer Hedrich | 2012 | Molecular Plant2012，5，6： | 7 |
| 16 | 粉末和块体性能、特性、贮存和流动显示文摘本书于2006年秋以德文出版,本英文版是由作者与J.Schwedes教授合作翻译的。 | Dietmar Schulz 吴永礼 | 2008 | 国外科技新书评介2008，，4： | 7 |
| 17 | Single-port versus multi-port cholecystectomy for patients with acute cholecystitis: a retrospective comparative analysis显示文摘BACKGROUND: Trans-umbilical single-port laparoscopic cholecystectomy for chronic gallbladder disease is becoming increasingly accepted worldwide. But so far, no reports exist about the challenging single-port surgery for acute cholecystitis. The objective of this study was to describe our experience with single-port cholecystectomy in comparison to the conventional laparoscopic technique. METHODS: Between August 2008 and March 2010, 73 patients with symptomatic gallbladder disease and histopathological signs of acute cholecystitis underwent laparoscopic cholecystec- tomy at our institution. Thirty-six patients were operated on with the single-port technique (SP group) and the data were compared with a control group of 37 patients who were treated with the multi-port technique (MP group). RESULTS: The mean age in the SP group was 61.5 (range 21-81) years and in the MP group was 60 (range 21-94) (P=0.712). Gender, ASA status and BMI were not significantly different. The number of white blood cells was different before [SP: 9.2 (range 2.8-78.4); MP: 13.2 (range 4.4-28.6); P=0.001] and after the operation [SP: 7.8 (range 3.5-184.8); MP: 11.1 (range 5-20.8); P=0.002]. Mean operating time was 88 (range 34-174) minutes in the SP group vs 94 (range 39-209) minutes in the MP group (P=0.147). Four patients (5%) required conversion to an open procedure (SP: 1; MP: 3; P=0.320). During the follow- up period of 332 (range 29-570) days in the SP group and 428 (range 111-619) days in the MP group (P=0.044), eleven (15%) patients developed postoperative complications (P=0.745) and two patients in the SP group required reoperation (P=0.154). CONCLUSIONS: Trans-umbilical single-port cholecystectomy for beginning acute cholecystitis is feasible and the complicationrate is comparable with the standard multi-port operation. In spite of our good results, these operations are difficult to perform and should only be done in high-volume centers for laparoscopic surgery with experience in single-port surgery. | Dietmar Jacob Roland Raakow | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 18 | The fungal UmSrt1 and maize ZmSUT1 sucrose transporters battle for plant sugar resources显示文摘The biotrophic fungus Ustilago maydis causes corn smut disease, inducing tumor formation in its host Zea mays. Upon infection, the fungal hyphae invaginate the plasma membrane of infected maize cells, establishing an interface where pathogen and host are separated only by their plasma membranes. At this interface the fungal and maize sucrose transporters, UmSrt1 and ZmSUT1, compete for extracellular sucrose in the corn smut/maize pathosystem. Here we biophysically characterized ZmSUT1 and UmSrt1 in Xenopus oocytes with respect to their voltage-,pH-and substrate-dependence and determined affinities toward protons and sucrose. In contrast to ZmSUT1,UmSrt1 has a high affinity for sucrose and is relatively pH-and voltage-independent. Using these quantitative parameters, we developed a mathematical model to simulate the competition for extracellular sucrose at the contact zone between the fungus and the host plant. This approach revealed that UmSrt1 exploits the apoplastic sucrose resource, which forces the plant transporter into a sucrose export mode providing the fungus with sugar from the phloem. Importantly, the high sucrose concentration in the phloem appeared disadvantageous for the ZmSUT1, preventing sucrose recovery from the apoplastic space in the fungus/plant interface. | Anke Wittek Ingo Dreyer Khaled A.S. Al-Rasheid Norbert Sauer Rainer Hedrich Dietmar Geiger | 2017 | Journal of Integrative Plant Biology2017，59，6： | 6 |
| 19 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 20 | 车辆与行人碰撞事故中下肢损伤风险研究显示文摘研究行人与车辆碰撞事故中下肢损伤风险,并确定碰撞速度和行人年龄、身高以及体重等损伤相关参数值在下肢轻微损伤组和严重损伤组之间的分布是否存在显著差异。为此,首先从德国深入事故研究数据库(GIDAS)中挑选出354个带有行人下肢损伤的案例来进行单因素方差分析,接着利用逻辑回归分析方法建立行人下肢严重损伤风险函数模型,分析车辆碰撞速度和行人年龄、身高以及体重对行人下肢严重损伤风险的影响。分析结果表明:碰撞速度和行人年龄是影响行人下肢严重损伤的显著性因素,而体重与身高不是影响行人下肢严重损伤的显著性因素;并且行人下肢严重损伤风险与碰撞速度以及行人年龄正相关。当碰撞速度为43 km/h时,行人下肢严重损伤风险达到50%。 | 王丙雨 杨济匡 OTTE Dietmar 王方 | 2016 | 振动与冲击2016，35，23： | 5 |
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