|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | Smoking,diabetes,and blood cholesterol differ in their associations with subclinical atherosclerosis:the multiethnic study of atherosclerosis (MESA)显示文摘 | Sharrett AR Ding J Criqui MH | 2005 | Epub ahead of print2005，43，： | 1 |
| 3 | Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia 显示文摘 | Ding DC Chiang MH Lai HC | 2009 | Eur J Obstet Gynecol Reprod Biol2009，147，2： | 1 |
| 4 | Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia显示文摘 | Ding DC Chiang MH Lai HC | | 0，，： | 1 |
| 5 | The role of mucopoly saccharide induction in treatment of experimental osteoarthritis in rats by ultrasound显示文摘 | Huang MH Tsau JC Ding HJ | 1997 | Kaohsiung J Med Sci1997，13，11： | 1 |
| 6 | Relationship between the geometry and quantitative morphology of the left anterior descending coronary artery 显示文摘 | Friedman MH Baker PB Ding Z | 1996 | Atheroselerosis1996，125，2： | 1 |
| 7 | Smoking, diabetes, and blood cholesterol differ in their associations with subclinical athemsclemsis : the multiethnic study of atherosclerosis (MESA) 显示文摘 | Sharrett AR Ding J Criqui MH | 2006 | Atherosclerosis2006，186，2： | 1 |
| 8 | Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia显示文摘 | Ding DC Chiang MH Lai HC | | 0，，02： | 1 |
| 9 | Effects of cardiacmotion on right coronary artery hemodynamics显示文摘 | Zeng D Ding Z Friedman MH | 2003 | AnnBiomed Eng2003，31，4： | 1 |
| 10 | Biochemical inhibition of the acetyhransferases ATasel and ATase2 reduces β -secretase ( BACE1 ) levels and Aβ generation 显示文摘 | Ding Y Ko MH Pehar M | 2012 | J Biol Chem2012，287，11： | 1 |
| 11 | Sailing through the Late Pleistocene:unusual historical demography of an East Asian endemic,the Chinese Hwamei (Leucodioptron canorum canorum),during the last glacial Period显示文摘 | Li SH Yeung CKL Feinstein J Han LX Le MH Wang CX Ding P | | 0，，： | 1 |
| 12 | Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings 显示文摘 | Huang MH Ding CX | 2000 | Biomaterials2000，21，8： | 1 |
| 13 | Biochemical inhibition of the acetyltransferases ATasel and ATase2 reduces -secretase (BACE1) levels and A generation显示文摘 | Ding Y Ko MH Pehar M | 2012 | J Biol Chem2012，287，11： | 1 |
| 14 | Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia显示文摘 | Ding DC Chiang MH Lai HC | 2009 | Eur J Obstet Gynecol Repord Biol2009，147，： | 1 |
| 15 | Smoking,diabetes,and blood cholesterol ditier in their associations with Subelinical atherosclerosis:The Muhiethnic Study of Atherosclerosis(MESA)显示文摘 | Ding J Criqui MH | 2005 | Atherosclerosis2005，，： | 1 |
| 16 | Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis:A histopathological study显示文摘 | Ding L Zhao MH Zou WZ | 2004 | Lupus2004，13，2： | 1 |
| 17 | The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine显示文摘 | Bonnet MH Balkin TJ Dinges DF | 2005 | Sleep2005，28，： | 1 |
| 18 | Smoking,diabetes,and blood cholesterol differ in their associations with subclinical atherosclerosis:the MultiEthnic Study of Atherosclerosis(MESA)显示文摘 | Sharrett AR Ding J Criqui MH el al | 2006 | Atherosclerosis2006，186，2： | 1 |
| 19 | A novel evolution-based method for detecting gene-gene interactions显示文摘 | Rao SQ Yuan MQ Zuo XY Su WY Zhang F Huang K Lin MH Ding YL | | 0，，10： | 1 |
| 20 | Smoking,diabetes,and blood cholesterol differ in their associations with subclinical ather- osclerosis: the multiethnic study of atherosclerosis (MESA)显示文摘 | Sharrett AR Ding J Criqui MH el al | 2006 | Atherosclerosis2006，186，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员