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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Perspectives in alkline phosphatase research显示文摘 | DONALD W M | 1992 | Clin Chem1992，38，12： | 1 |
| 3 | Design considerations and topology selection for 120 kW IGBT converter for EV fast charging显示文摘 | Nasser H Kutkut Deepak M Divan Donald W Novotny | 1998 | IEEE Transactions on Power Electronics1998，13，1： | 1 |
| 4 | Current control of VSI-PWM inverters显示文摘 | Brod David M Donald W N | 1985 | IEEE Transactions on Industry Applications1985，21，3： | 1 |
| 5 | The Mixing of Solids in Tumbling Mixers I 显示文摘 | Carley-Macauly K W Donald M B | 1962 | Chemical Engineering Science1962，17，7： | 1 |
| 6 | Sulfurcoated fertilizers for controlled release: pilot plant production 显示文摘 | Glenn M B Donald W R Oscar E M | 1971 | Agric Food Chem1971，19，5： | 1 |
| 7 | Electromagnetic scattering by surfaces of arbitrary shape 显示文摘 | Sadasiva M R Donald R W Allen W G | 1982 | IEEE Trans - AP1982，30，3： | 1 |
| 8 | Characterization and reactivity of iron nanoparticlesprepared with added Cu, Pd, and Ni显示文摘 | DONALD R B DEAN W M JAMES E A | 2010 | Environmen-tal Science and Technology2010，44，： | 1 |
| 9 | Development of an immunoassay for the pyrcthroid insecticide esfenvalerate显示文摘 | SHAN G M DONALD W S INGRID W | 1999 | Journal of Agricultural and Food Chemistry1999，47，5： | 1 |
| 10 | Sequence analysis of ARI,a noval OXA laetamase,responsible for inipenim resistance in Acinetobacter baumannii 6 B92显示文摘 | SCAIFE W AMYES S G | 2004 | Antimierob Agents Chemother2004，44，： | 1 |
| 11 | Anisotropy correction for devlated-well sonic logs: application to seismic well tie显示文摘 | Brian E H John M H Donald W I | 2003 | Geophysics2003，68，2： | 1 |
| 12 | An environmental rationale for re- tention of endangered chemicals显示文摘 | Donald W James M C | 1997 | Science1997，278，： | 1 |
| 13 | Sequence analysis of ARI-, a noval OXA-lactamase, responsible for inipenim resistance in Acinetobacter baumannii 6 B92 显示文摘 | DONALD H M SCAIFE W AMYES S G | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 14 | Second-order nonlinearity in poled-polymer systems显示文摘 | Donald M B Robert D M Cecilia A W | 1994 | Chem Rev1994，94，： | 1 |
| 15 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 16 | Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 显示文摘 | Donald H M Scaife W Amyes S G | 2000 | Antimierob Agents Chemother2000，44，1： | 1 |
| 17 | Television and Attitudes Toward Mental Health Issues : Cultivation Analysis and the Third - person Effect 显示文摘 | Donald L Diefenbach M D W | 2007 | Joumal of Community Psychology2007，35，2： | 1 |
| 18 | Sequence analysis of AR 12 1, a novel OXA2 Lactamase, responsible for imipenem resist- ance in Acinetobacter baumannii 显示文摘 | DONALD H M SCAIFE W AMYES S G | 2000 | Antimicrob Agents Chemother2000，4，1： | 1 |
| 19 | Characterization of the basic fraction of marijuana smoke by capillary gas chromatography/mass spectrometry 显示文摘 | Novotny M Frauco M Donald W | 1981 | Anal Chem1981，53，： | 1 |
| 20 | Effects of substrata on the polarization of bovine endometrial epithelial cells in vitro 显示文摘 | Linda M J Erby W Donald H S | 1990 | Cell and Tissue Research1990，261，1： | 1 |
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