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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 3 | Cryopreservation of eguine embryos by open pulled straw, cryoloop, or conventional slow cooling methods显示文摘 | Oberstein N O Donovan M K Bruemmer J E | 2001 | Theriogenology2001，55，： | 2 |
| 4 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 5 | Adaptability in the workplace: Development of a taxonomy of adaptive performance 显示文摘 | PulakosED Arad S Donovan M A Plamondon K E | 2000 | Journal of Applied Psychology2000，85，： | 1 |
| 6 | Gastric emptying in diabetes: clinical significance and treatment 显示文摘 | Horowitz M O'Donovan D Jones KL | 2002 | Diabet Med2002，19，3： | 1 |
| 7 | The treatment of childhood social phobia :The effectiveness of involvement 显示文摘 | Spence S H Donovan C Brechman - Toussaint M | 2000 | Journal of Child Psychology and Psychiatry2000，41，6： | 1 |
| 8 | Genome-wide analysis of histone modifications by ChiP-on-chip显示文摘 | Huebert D J Kamal M O'Donovan A | 2006 | Methods2006，40，4： | 1 |
| 9 | Microwave digestion of sediment, soils and urban particulate matter for trace metal analysis 显示文摘 | Sandroni V Smith C M M Donovan A | 2003 | Talanta2003，60，： | 1 |
| 10 | Recent genomic advances in schizophrenia显示文摘 | Doherty J O'Donovan M Owen M | 2012 | Clin Genet2012，81，2： | 1 |
| 11 | Neurophysio- logical approaches to chronic pain following spinal cord injury显示文摘 | Donovan W Dimitrijevic M Dahm L | 1982 | Paraplegia1982，20，3： | 1 |
| 12 | Effects of an interven- tion to improve communication about end-of-life care among African Americans with chronic kidney disease显示文摘 | Song M K Donovan H S Piraino B M | 2010 | Applied Nursing Re search2010，23，2： | 1 |
| 13 | The effect of the nitrification inhibitor dicyandiamide (DCD) on herbage production when applied at different times and rates in the autumn and winter显示文摘 | O'Connor PJ Hennessy D Brophy C O'Donovan M Lynch MB | 2012 | Agricultural Ecosystems & Environment2012，152，： | 1 |
| 14 | Effect of pro- tein deprivation on subsequent efficiency of dietary protein utilization in finishing pigs 显示文摘 | Whang K Y Donovan S M Easter R A | 2000 | Anim Sci2000，13，4： | 1 |
| 15 | Calorimetric determination of the amylose content of starches based on formation and melting of the amylose-lysolectithin complex显示文摘 | DONOVAN J W | 1981 | J food Sci1981，46，： | 1 |
| 16 | Frequency of peristomal complications 显示文摘 | Donovan A M | 2001 | Ostomy Wound Manage2001，47，8： | 1 |
| 17 | Surgical correction of the buried penis, description of a ctassition system and a technique to correct the disorder显示文摘 | Maizels M Zaontz M Donovan J | 1986 | J Urol1986，136，： | 1 |
| 18 | Microwave digestion of sediment, soils and urban particulate matter for trace metal analysis 显示文摘 | SANDRONI V SMITH C M M DONOVAN A | 2003 | Talanta2003，60，： | 1 |
| 19 | The phage K lyric enzyme LysK and lysostaphin act synergistically to kill MRSA显示文摘 | Becker S C Foster-Frey J Donovan D M | 2008 | Ferns Microhiol Lett2008，287，2： | 1 |
| 20 | Synthesis of Well-defined, Stimuli-responsive,Water-soluble Polymers via the RAFT Process 显示文摘 | Donovan M S Lowe A B McCormick C L | 1999 | Polym Prep1999，40，2： | 1 |
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