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| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 3 | Jittor:a novel deep learning framework with meta-operators and unified graph execution显示文摘This paper introduces Jittor,a fully just-in-time(JIT)compiled deep learning framework.With JIT compilation,we can achieve higher performance while making systems highly customizable.Jittor provides classes of Numpy-like operators,which we call meta-operators.A deep learning model built upon these meta-operators is compiled into high-performance CPU or GPU code in real-time.To manage metaoperators,Jittor uses a highly optimized way of executing computation graphs,which we call unified graph execution.This approach is as easy to use as dynamic graph execution yet has the efficiency of static graph execution.It also provides other improvements,including operator fusion,cross iteration fusion,and unified memory. | Shi-Min HU Dun LIANG Guo-Ye YANG Guo-Wei YANG Wen-Yang ZHOU | 2020 | Science China(Information Sciences)2020，63，12： | 10 |
| 4 | PA1b, a plant peptide, induces intracellular [Ca^(2+)] in- crease via Ca^(2+) influx through the L-type Ca^(2+) channel and triggers secretion in pancreatic β cells显示文摘Using alginic acid to adsorb polypeptides at pH 2.7, we isolated a peptide pea albumin 1b (PA1b) from pea seeds. The PA1b is a single chain peptide consisting of 37 amino acid residues with 6 cysteines which constitutes the cystine-knot structure. Using microfluorometry and patch clamp techniques, we found that PA1b significantly elevated the intracellular calcium level ([Ca2+ ]i) and elicited membrane capacitance increase in the primary rat pancreatic β cells. The PA1b effect on [Ca2+]i elevation was abolished in the absence of extracellular Ca2+ or in the presence of L-type Ca2+ channel blocker, ni- modipine. Interestingly, we found that PA1b significantly depolarized membrane potential, which could lead to the opening of voltage-dependent L-type Ca2+ channels and influx of extracellular Ca2+, and then evoke robust secretion. In this study we identified the plant peptide PA1b which is capable of affecting the excitability and function of mammalian pancreatic β cell. | HU ZhiTao1, DUN XinPeng1, ZHANG Ming1, ZHU HongLiang1, XIE Li1, WU ZhengXing1, CHEN ZhengWang1 & XU Tao1,2 1 Joint Laboratory of Institute of Biophysics and Huazhong University of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. | 2007 | Science China(Life Sciences)2007，50，3： | 5 |
| 5 | Effect of toll-like receptor 3 agonist poly I:C on intestinal mucosa and epithelial barrier function in mouse models of acute colitis显示文摘AIM To investigate potential effects of poly I:C on mucosal injury and epithelial barrier disruption in dextran sulfate sodium(DSS)-induced acute colitis.METHODS Thirty C57BL/6 mice were given either regular drinking water(control group) or 2%(w/v) DSS drinking water(model and poly I:C groups) ad libitum for 7 d. Poly I:C was administrated subcutaneously (20 μg/mouse) 2 h prior to DSS induction in mice of the poly I:C group. Severity of colitis was evaluated by disease activity index, body weight, colon length, histology and myeloperoxidase (MPO) activity, as well as the production of proinflammatory cytokines, including tumor necrosis factor-α(TNF-α), interleukin 17(IL-17) and interferon-γ (IFN-γ). Intestinal permeability was analyzed by the fluorescein isothiocyanate labeleddextran (FITC-D) method. Ultrastructural features of the colon tissue were observed under electron microscopy. Expressions of tight junction(TJ) proteins, including zo-1, occludin and claudin-1, were measured by immunohistochemistry/immunofluorescence, Western blot and real-time quantitative polymerase chain reaction(RT-qPCR).RESULTS DSS caused significant damage to the colon tissue in the model group. Administration of poly I:C dramatically protected against DSS-induced colitis, as demonstrated by less body weight loss, lower disease activity index score, longer colon length, colonic MPO activity, and improved macroscopic and histological scores. It also ameliorated DSS-induced ultrastructural changes of the colon epithelium, as observed under scanning electron microscopy, as well as FITC-D permeability. The m RNA and protein expressions of TJ protein, zo-1, occludin and claudin-1 were also found to be significantly enhanced in the poly I:C group, as determined by immunohistochemistry/immunofluorescence, Western blot and RT-q PCR. By contrast, poly I:C pretreatment markedly reversed the DSS-induced up-regulated expressions of the inflammatory cytokines TNF-α, IL-17 and IFN-γ.CONCLUSION Our study suggested that poly I:C may protect against DSS-induced colitis through maintaining integrity of the epithelial barrier and regulating innate immune responses, which may shed light on the therapeutic potential of poly I:C in human colitis. | Hong-Wei Zhao Yue-Hong Yue Hua Han Xiu-Li Chen Yong-Gang Lu Ji-Min Zheng Hong-Tao Hou Xiao-Meng Lang Li-Li He Qi-Lu Hu Zi-Qian Dun | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 6 | Three Super Active Regions in the Descending Phase of Solar Cycle 23显示文摘We analyze the magnetic configurations of three super active regions,NOAA 10484, 10486 and 10488, observed by the Huairou Multi-Channel Solar Telescope (MCST) from 2003 October 18 to November 4. Many energetic phenomena,such as flares (including a X-28 flare) and coronal mass ejections (CMEs), occurred during this period. We think that strong shear and fast emergence of magnetic flux are the main causes of these events. The question is also of great interest why these dramatic eruptions occurred so close together in the descending phase of the solar cycle. | Hong-Qi Zhang, Xing-Ming Bao, Yin Zhang, Ji-Hong Liu, Shu-Dong Bao, Yuan-Yong Deng, Wei Li, Jie Chen, Jin-Ping Dun, Jiang-Tao Su, Juan Guo, Xiao-Fan Wang, Ke-Liang Hu, Gang-Hua Lin and Dong-Guang WangNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 | 2003 | Chinese Journal of Astronomy and Astrophysics2003，3，6： | 2 |
| 7 | The mechanisms underlying the unique pharmacodynamics of nateglinide 显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，，： | 1 |
| 8 | The mechanisms underlying the unique pharmacodynamics of nateglinide显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，46，1： | 1 |
| 9 | Glucose-dependent and glucose-sensitizing insulinotropic effect of nateglinide:comparison to sulfonylureas and repaglinide显示文摘 | Hu S Wang S Dunning BE | 2001 | Int J Exp Diabetes Res2001，2，： | 1 |
| 10 | The mechanisms underlying the unique pharmacodynamics of nateglinide显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，46，1： | 1 |
| 11 | The mechanisms underlying the unique pharmacodynamics of nateglinide 显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，46，1： | 1 |
| 12 | Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta - cell K (ATP) channels 显示文摘 | Hu S Wang S Dunning BE | 1999 | J Pharmacol Exp Ther1999，291，3： | 1 |
| 13 | Uniform fabrication of Ge nanocrystals embedded into SiO_2 film via neutron transmutation doping显示文摘Nanocrystalline74Ge embedded SiO2 films were prepared by employing ion implantation and neutron transmutation doping methods.Transmission electron microscopy, energy dispersive x-ray spectroscopy, and photoluminescence of the obtained samples were measured. The existence of As dopants transmuted from74 Ge is significant to guarantee the uniformity and higher volume density of Ge nanocrystals by tuning the system's crystallinity and activating mass transfer process. It was observed that the photoluminescence intensity of Ge nanocrystals increased first then decreased with the increase of arsenic concentration. The optimized fluence of neutron transmutation doping was found to be5.5 1017 cm 2to achieve maximum photoluminescence emission in Ge embedded SiO2 film. This work opens a route in the three-dimensional nanofabrication of uniform Ge nanocrystals. | Wei Liu Tiecheng Lu Qingyun Chen Youwen Hu Shaobo Dun Issai Shlimak | 2014 | Progress in Natural Science:Materials International2014，24，3： | 1 |
| 14 | The mechanisms underlying the unique pharmacodynamics of nateglinide 显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，46，1： | 1 |
| 15 | Conversion of yellow wine lees into high-protein yeast culture by solid-state fermentation显示文摘 | HU Y PAN L DUN Y | 2014 | Bioteehnology & Biotechnolngleal Equipment2014，28，5： | 1 |
| 16 | Photoluminescence study of Ge nanocrystals irradiated by reactor neutron flux显示文摘 | Dun S B Lu T C Hu Q etal | 2007 | Nucl Instrum Meth B2007，264，2： | 1 |
| 17 | The Raman spectroscopy of neutron transmutation doping isotope ^74Germanium nanocrystals embedded in SiO2 matrix显示文摘 | Hu Y W Lu T C Dun S B | 2007 | Solid State Commun2007，141，9： | 1 |
| 18 | The mechanisms underlying the unique pharmacodynamics of nateglinide 显示文摘 | Hu S Boettcher BR Dunning BE | 2003 | Diabetologia2003，46，1： | 1 |
| 19 | Triangular fuzzy decision-theoretic rough sets显示文摘 | Decui Liang Dun Liu Witold Pedrycz Pei Hu | 2013 | International Journal of Approximate Reasoning2013，，8： | 1 |
| 20 | Neutron transmutation doping effect on the optical property of germanium nanocrystals显示文摘 | Youwen Hu Tiecheng Lu Shaobo Dun Qiang Hu Caofeng You Qingyun Chen Ningkang Huang Lev Resnick Issai Shlimak Kai Sun Wen Xu | 2009 | Scripta Materialia2009，，10： | 1 |
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