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| 1 | Patient comfort and quality in colonoscopy显示文摘AIM: To explore the relationship of patient comfort and experience to commonly used performance indicators for colonoscopy. METHODS: All colonoscopies performed in our four endoscopy centres are recorded in two reporting systems that log key performance indicators. From 2008 to 2011, all procedures performed by qualified endoscopists were evaluated; procedures performed by trainees were excluded. The following variables were measured: Caecal intubation rate (CIR), nurse-reported comfort levels (NRCL) on a scale from 1 to 5, polyp detection rate (PDR), patient experience of the procedure (worse than expected, as expected, better than expected), and use of sedation and analgesia. Pearson' s correlation coefficient was used to identify relationships between performance indicators.RESULTS: A total of 17027 colonoscopies were performed by 23 independent endoscopists between 2008 and 2011. Caecal intubation rate varied from 79.0% to 97.8%, with 18 out of 23 endoscopists achieving a CIR of > 90%. The percentage of patients experiencing significant discomfort during their procedure (defined as NRCL of 4 or 5) ranged from 3.9% to 19.2% with an average of 7.7%. CIR was negatively correlated with NRCL-45 (r=-0.61, P < 0.005), and with poor patient experience (r=-0.54, P < 0.01). The average dose of midazolam (mean 1.9 mg, with a range of 1.1 to 3.5 mg) given by the endoscopist was negatively correlated with CIR (r=-0.59, P < 0.01). CIR was positively correlated with PDR (r=0.44, P < 0.05), and with the numbers of procedures performed by the endoscopists (r=0.64, P < 0.01). CONCLUSION: The best colonoscopists have a higher CIR, use less sedation, cause less discomfort and find more polyps. Measuring patient comfort is valuable in monitoring performance. | Vivian E Ekkelenkamp Kevin Dowler Roland M Valori Paul Dunckley | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 2 | Impact of a simulation-based induction programme in gastroscopy on trainee outcomes and learning curves显示文摘BACKGROUND Pre-clinical simulation-based training(SBT)in endoscopy has been shown to augment trainee performance in the short-term,but longer-term data are lacking.AIM To assess the impact of a two-day gastroscopy induction course combining theory and SBT(Structured PRogramme of INduction and Training–SPRINT)on trainee outcomes over a 16-mo period.METHODS This prospective case-control study compared outcomes between novice SPRINT attendees and controls matched from a United Kingdom training database.Study outcomes comprised:(1)Unassisted D2 intubation rates;(2)Procedural discomfort scores;(3)Sedation practice;(4)Time to 200 procedures;and(5)Time to certification.RESULTS Total 15 cases and 24 controls were included,with mean procedure counts of 10 and 3(P=0.739)pre-SPRINT.Post-SPRINT,no significant differences between the groups were detected in long-term D2 intubation rates(P=0.332)or discomfort scores(P=0.090).However,the cases had a significantly higher rate of unsedated procedures than controls post-SPRINT(58%vs 44%,P=0.018),which was maintained over the subsequent 200 procedures.Cases tended to perform procedures at a greater frequency than controls in the post-SPRINT period(median:16.2 vs 13.8 per mo,P=0.051),resulting in a significantly greater proportion of cases achieving gastroscopy certification by the end of follow up(75% vs 36%,P=0.017).CONCLUSION In this pilot study,attendees of the SPRINT cohort tended to perform more procedures and achieved gastroscopy certification earlier than controls.These data support the role for wider evaluation of pre-clinical induction involving SBT. | Keith Siau James Hodson Peter Neville Jeff Turner Amanda Beale Susi Green Aravinth Murugananthan Paul Dunckley Neil D Hawkes | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，3： | 2 |
| 3 | Gene expression correlates of neurofibrillary tangles in Alzheimer's disease显示文摘 | Dunckley T Beach TG Ramsey KE | 2005 | Neurobiol Aging2005，19，： | 1 |
| 4 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
| 5 | Whole-genome analysis of sporadic amyotrophic lateral sclerosis显示文摘 | Dunckley T Huentelman M J Craig DW | 2007 | N Engl J Med2007，357，： | 1 |
| 6 | Genetics,transcriptomics,and proteomics of Alzheimer's disease显示文摘 | Papassotiropoulos A Fountoulakis M Dunckley T | 2006 | The Journal of Clinical Psychiatry2006，67，4： | 1 |
| 7 | Vancomycin-associated drug reaction with eosinophilia and systemic symptoms syndrome 显示文摘 | Young S Ojaimi S Dunckley H | 2014 | Intern Med J2014，44，7： | 1 |
| 8 | Lipofection of cultured mouse muscle cells: a direct comparison of lipofectamine and DOSPER显示文摘 | Dodds E Dunckley MG Naujoks K | 1998 | Gene Ther1998，5，4： | 1 |
| 9 | Prototype Evaluation and Redesign: Structuring the Design Space through Contextual Techniques 显示文摘 | SMITH A DUNCKLEY L | 2002 | Interacting with Computers2002，14，6： | 1 |
| 10 | Characterisation of novel point mutations in the survival motor neuron gene SMN, in three patients with SMA 显示文摘 | Dunckley MG Burglen L | 2001 | Hum Genet2001，108，4： | 1 |
| 11 | Gender effects on high frequency distortion product otoacoustic emissions in humans显示文摘 | Dunckley KT Dreisbach LE | 2004 | Ear Hear2004，25，6： | 1 |
| 12 | Whole-genome analysis of sporadic amyotrophic lateral sclerosis 显示文摘 | Dunckley T Huentelman M J Craig DW | 2007 | N Engl J Med2007，357，： | 1 |
| 13 | Altered neuronal gene expression in brain regions differentially affected by Alzheimer′s disease: a reference data set显示文摘 | Liang WS Dunckley T Beach TG | 2008 | Physiol Genom2008，33，2： | 1 |
| 14 | Lipofection of cultured mouse muscle ceils : a direct comparison of lipofectamine and DOSPER显示文摘 | Dodds E Dunckley MG Naujoks K | 1998 | Gene Ther1998，5，4： | 1 |
| 15 | Restless legs syndrome in Parkinson' s disease patients may improve with subtha- lamic stimulation显示文摘 | Driver- Dunckley E Evidente VG Adler CH | 2006 | Mov Disord2006，21，8： | 1 |
| 16 | Efficient coexpression and secretion of anti-atherogenic human apolipoprotein AI and lecithincholesterol acyltransferase by cultured muscle cells using adeno-associated virus plasmid vectors显示文摘 | Fan L Drew J Dunckley MG | 1998 | Gene Ther1998，5，10： | 1 |
| 17 | Direct reteoviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in viro显示文摘 | Wells DJ Walsh FS | 1993 | Hum Mol Genet1993，2，6： | 1 |
| 18 | Using XFDU for CAS- PAR information packaging显示文摘 | Dunckley M Ronen S Henis E A | 2010 | OCLC Systems & Services: Inter- national Digital Library Perspectives2010，26，2： | 1 |
| 19 | Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides显示文摘 | Dunckley MG Manoharan M Villiet P | 1998 | Hum Mol Genet1998，7，7： | 1 |
| 20 | Whole-ge- nome analysis of sporadic amyotrophie lateral sclerosis 显示文摘 | Dunckley T Huentelman MJ Craig DW | 2007 | N Engl J Med2007，357，77： | 1 |
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