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| 1 | Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity显示文摘AIM Several triggering receptors have beendescribed to be involved in natural killer(NK)cell-mediated target cytotoxicity.In these studies,NKcells derived from blood or spleen were used.Pitcells are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK cells.The aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget cells.METHODS 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,respectively.RESULTS Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and ANK61antigen.Treatment of pit cells with monoclonalantibody(mAb)to CD45(ANK74)not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit cells.The mAbs to NKR-P1A(3.2.3)and ANK61 antigen(ANK61)had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive(FcγR+)P815 cytolysis andapoptosis.This enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof granzymes.CONCLUSION These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and apoptosis.NKR-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway. | David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 2 | Hyperspectral Vegetation Indices and Their Relationships with Agricultural Crop Characteristics显示文摘 | Prasad S Thenkabail Ronald B Smith Eddy De Pauw | 2000 | Remote Sensing of Environment2000，，2： | 2 |
| 3 | Hyperspectral vegetation indices and their relationship with agricuhural crop characteristics 显示文摘 | PRASD S T RONALD B S EDDY D P | 2000 | Remote Sensing Environment2000，71，2： | 1 |
| 4 | In vitro models to predict blood-brain barrier permeability显示文摘 | Eddy E P Maleet B E Hart T K | 1997 | Adv Drug Del Rev1997，23，123： | 1 |
| 5 | Diabetes Risk Calculator: a simple tool for detecting undiagnosed diabetes and pre-diabetes 显示文摘 | HEIKES K E EDDY D M ARONDEKAR B | 2008 | Diabetes Care2008，31，5： | 1 |
| 6 | Surface absorption of aluminium by gill tissue and body mucus of rainbow trout, Salmo gair&wr, at the onset of episodic exposure 显示文摘 | Handy R D Eddy F B | 1989 | J Fish Bio1989，34，： | 1 |
| 7 | Effects of Microcystis cells, cell extracts and lipopolysaccharide on drinking and liver function in rainbow trout Oncorhynchus mykiss Walbaum 显示文摘 | Best J H Eddy F B Codd G A | 2003 | Aquat Toxicol2003，64，4： | 1 |
| 8 | In vitro evidence for the ionoregulatory role of rainbow trout mucus in acid, acid/ aluminiuman and zinc toxicity 显示文摘 | Handy R D Eddy F B Romain G | 1989 | J Fish Bio1989，35，： | 1 |
| 9 | Liver damage in brown t rout, Salmo trutta L, and rainbow trout, Oncorhynchus mykiss(Walbaum) , following administ ration of the cyanobactefial hepatotoxin MC - LR via the dorsal aorta 显示文摘 | BURY N R MCGEER J C EDDY F B | 1997 | J Fish Dis1997，，20： | 1 |
| 10 | Randomised trial of safety andefficacy of immediate postoperative enteral feeding in patientsundergoing gastrointestinal resection显示文摘 | Cornelia S Eddie L Paul B | 2006 | BMJ2006，322，6： | 1 |
| 11 | Laparoscopic nephrectomy显示文摘 | Poulsen EU Eddy B Poulsen J | 2005 | Scand J Urol Nephrol2005，39，2： | 1 |
| 12 | Clinical evaluation of a novel laparoscopic port (R-port ) and e- volution of the single laparoscopic port procedure (SLiPP)显示文摘 | Rane A Kommu S Eddy B Abe C Bonkat G Reich O | 2007 | J Endourol2007，21，1： | 1 |
| 13 | Clinical evaluation of a novel laparoscopic port (R-port) and evolution of the single laparoscopic port procedure (SLiPP)显示文摘 | Rane A Kommu S Eddy B Abe C Bonkat G Reich O | 2007 | J Endourol2007，21，1： | 1 |
| 14 | The effects of the cyanobacterium Microcystis aeruginosa, the cyanobacterial hepatotoxin MC-LR, and ammonia on growth rate and ionic regulation of brown trout 显示文摘 | Bury N R Eddy F B Codd G A | 1995 | Journal of Fish Biology1995，46，6： | 1 |
| 15 | Surfaceinduced transients in gallium nitride nanowires 显示文摘 | Simpkins B S Mastro M A Eddy C R | 2009 | Journal of physical chemistry : C2009，113，22： | 1 |
| 16 | Acute heat stress induces oxidative stress in broiler chickens显示文摘 | HAI L EDDY D JOHAN B | 2006 | Comparative Biechemistry and Physiology Part A2006，144，： | 1 |
| 17 | Effects of nitric oxide synthase inhibi tors and a substrate,L-arginine,on the cardiac function of juvenile salmonid fish显示文摘 | Eddy E B Tibbs P | 2003 | Comparative Biochemistry and Physiology2003，135，2： | 1 |
| 18 | Clinical evaluation of a novellaparoscopic port(R port)and evolution of the single laparoscopic portprocedure(SLiPP)显示文摘 | Rane A Kommu S Eddy B | 2007 | JEndourol2007，21，： | 1 |
| 19 | Dihydromorphinone hydrochloride显示文摘 | Eddy N B | 1933 | JAMA1933，100，： | 1 |
| 20 | Transport of nitrite across fish gills 显示文摘 | Bath R N Eddy F B | 1980 | Journal of Experimental Zoology1980，214，1： | 1 |
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