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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Vaccination against autoimmune mouse diabetes with a T cell epitope of the human 65-kDa heat shock protein显示文摘 | Elias D Reshef T Birk OS | 1991 | Proc Natl Acad Sci USA1991，88，8： | 1 |
| 3 | Evaluating levoglucosan as an indicator of biomass burning in Carajas, amazonia: A comparison to the charcoal record显示文摘 | Elias V O Simoneit B R T Cordeiro R C | 2001 | Geochimica et Cosmochimica Acta2001，65，2： | 1 |
| 4 | Detecting organic tracers from bio- mass burning in the atmosphere 显示文摘 | Simoneit B R T Elias V O | 2001 | Marine Pollution Bulletin2001，42，10： | 1 |
| 5 | Long - term results in surgically treated acetabular fractures through the posterior approaches 显示文摘 | Panagiotis T Elias P Constantinos M | 2007 | J Trauma2007，62，2： | 1 |
| 6 | Transgenic modeling of interleukin-13 in the lung显示文摘 | Elias JA Zheng T Lee CG | 2003 | Chest2003，123，3： | 1 |
| 7 | New insights into the pathogenesis of asthma显示文摘 | Elias J A Lee C G Zheng T | 2003 | J Clin Invest2003，111，3： | 1 |
| 8 | Stress alters cutaneous permeability barrier homeostasis 显示文摘 | Denda M Tsuchiya T Elias PM | 2000 | Am J Physiol Regul Integr Comp Physiol2000，278，2： | 1 |
| 9 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 10 | Hepatic tumors treated with percutaneous radio-frequency ablation: CT and MR imaging follow-up 显示文摘 | Dromain C de Baere T Elias D | 2002 | Radiology2002，223，1： | 1 |
| 11 | Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors 显示文摘 | KOSLOFF M ELIA N JOEL-ALMAGOR T | 2003 | EMBO J2003，22，3： | 1 |
| 12 | Attention-deficit/hyperactivity disor- der genomics :update for clinicians 显示文摘 | Elia J Sackett J Tumer T | 2012 | Curr Psychiatry Rep2012，14，5： | 1 |
| 13 | Effective process design for the production of HIC-resistant linepipe steels 显示文摘 | NIETO J ELiAS T LoPEZ G | 2013 | Journal of Materials Engineering and Performance2013，22，9： | 1 |
| 14 | Heated intra-operative intraperitoneal oxaliplatin plus irinotecan after complete resection of peritoneal carcinomatosis pharmacokinetics,tissue distribution and tolerance显示文摘 | Elias D Matsuhisa T Sideris L | 2004 | Ann Oncol2004，15，10： | 1 |
| 15 | Post-project reviews as a key project management comprtence 显示文摘 | Anbari Frank T Carayannis Elias G Voetsch Robert James | 2008 | Technovation2008，28，10： | 1 |
| 16 | Vaccination against autoim- mune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein显示文摘 | Elias D Reshef T Birk O S | 1991 | Pro Natl Acad Sci1991，88，8： | 1 |
| 17 | Learning analytics: Definitions, processes and potential 显示文摘 | ELIAS T | 2011 | Learning2011，23，13： | 1 |
| 18 | 查看详情显示文摘 | Ullah A Vasanthan T Bressler D Elias A L Wu J P | | 0，，： | 1 |
| 19 | Disruption of the lcn 2 gene in mice suppresses primary tumor formation but does not decrease lung metastasis显示文摘 | Berger T Cheung CC Elia AJ | 2010 | Proc Natl Aead Sci USA2010，107，7： | 1 |
| 20 | Evidence for abnormal fermentation in the irritable bowel syndrome显示文摘 | King T S Elia M Hunter J | 1998 | Lancet1998，352，： | 1 |
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