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| 1 | Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis显示文摘Objective:To explore antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis(A.officinalis).Methods:In the present study the leaf extracts of A.officinalis were examined for its antibacterial potential using five different solvents against some reference strains of human pathogenic bacteria for the crude extract.Maximum activity was observed for ethyl acetate and hence different concentrations like 15μL,25μL,and 50μL of ethyl extracts was checked for its antibacterial activity.Partial purification of crude extract was carried by column chromatography and fractions were analyzed using gas chromatography-mass spectrometry(GC-MS) to identify compounds.Results:The crude ethyl acetate extracts of A.officinalis showed remarkable antibacterial activity with zones of inhibition of 13 mm against Eschericia coli(E.coli) and 11 mm against Staphylococcus aureus (S.aureus).Fraction 13(ethyl acetate:methanol= 8:2) as the most potent one against with the minimal inhibitory concentration of 30 mm against E.coli and 25 mm against S.aureus.The GCMS resultsof active column fraction(F13) revealed that the active principals were a mixture of hydroxy- 4 methoxybenzoic acid,diethyl phthalate,oleic acid.Conclusions:The leaf extracts with proven antibacterial effects can clearly be directed towards cancer treatment as to inhibiting cancer cell growth.The limited number of test organisms owes to a constraint of resource.So,the effect of strong bursts of leaf extracts on human pathogenic bacteria should further be tested on a wide range of test organisms. | Valentin Bhimba B J Meenupriya Elsa Lycias Joel D Edaya Naveena Suman kumar M Thangaraj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 13 |
| 2 | Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off. | B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 3 | Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies显示文摘 | Nora M A P Carlos A P Elsa B D | 2003 | Carbohyd Res2003，338，2： | 1 |
| 4 | Xylans from scinaia hatei: structural features, sulfation and anti-HSV activity 显示文摘 | Pinaki M Carlos A P Elsa B D et a | 2010 | Int J Biol Macromol2010，46，2： | 1 |
| 5 | Analysis of the dynamics of bacterial communities in the rhizophere of the chrysanthemum via denaturing gradient gel electrophoresis and substrate utilization 显示文摘 | Duineveld B M Rosado A Elsas J D | 1998 | Appl Environ Microbiol1998，64，12： | 1 |
| 6 | Activation induced deaminsae is required for the chromosomal breaks in c-myc that lead to c-myc/ IgH translocations显示文摘 | Davide F Anne B Elsa C | 2008 | Cell2008，135，6： | 1 |
| 7 | Effect of a Chronic GSM 900 MHz Exposure on Glia in the Rat Brain显示文摘 | Mohamed A Elsa B Christelle G | 2008 | Bio medicine & Pharmacotherapv2008，62，： | 1 |
| 8 | Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)显示文摘 | Sutapa Mazumder Prodyut K Ghosal Carlos A Pujol Mar??a J Carlucci Elsa B Damonte Bimalendu Ray | 2002 | International Journal of Biological Macromolecules2002，，1： | 1 |
| 9 | Analysis of the dynamics of bacterial communities in the rhizophere of the chrysan- themum via denaturing gadient gel electmphoresis and substrate u- tilization patterns 显示文摘 | DUINEVELD B M RESADO A ELSAS J D | 1998 | Appl Environ Microbiol1998，64，12： | 1 |
| 10 | The histone deacetylase in- hibitor sodium valproate cause limited transcriptional change in mouse embryonic stem cells but selectively overrides Polyeomb- mediated Hoxb silencing 显示文摘 | Elsa B Hannah S John A | 2013 | Epigenetic Chromatin2013，6，11： | 1 |
| 11 | Multiple-drug–resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease: Prevalence, risk factors, and outcome显示文摘 | Saad Nseir Christophe Di Pompeo Béatrice Cavestri Elsa Jozefowicz Martine Nyunga Stéphane Soubrier Micheline Roussel-Delvallez Fabienne Saulnier Daniel Mathieu Alain Durocher | 2006 | Critical Care Medicine2006，，12： | 1 |
| 12 | Analysis of the dynamics of bacterial communities in the rhizosphere of the chrysanthemum via denaturing gradient gel electrophoresis and substrate utilization patterns显示文摘 | Duineveld B M Rosado A S van Elsas J D | 1998 | Appl Environ Microbiol1998，64，12： | 1 |
| 13 | Vigilance,alertness,or sustained attention:Physiological basis and measurement显示文摘 | Oken B S Salinsky M C Elsas S M | | 0，，09： | 1 |
| 14 | Activation Induced Deaminase is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations 显示文摘 | Davide F Anne B Elsa C | 2008 | Cell2008，135，6： | 1 |
| 15 | Induced natural transformation of Acinetobacter calcoaceticus in soil microcosms显示文摘 | NIELSENKM B BONES A M Van ELSAS J D | 1997 | Appl Environ Microbiol1997，63，10： | 1 |
| 16 | Activation induced deaminase is required for the chromosomal breaks in c-Myc that lead to c-Myc/IgH translocations显示文摘 | Davide F Anne B Elsa C | 2008 | Cell2008，135，6： | 1 |
| 17 | Analysis of the dynamics of bacterial communities in the rhizosphere of the chrysanthemum via denaturing gradient gel electrophoresis and substrate utilization patterns 显示文摘 | Duineveld B M Rosado A S Van Elsas J D | 1998 | Applied and Environmental Micbiology1998，64，12： | 1 |
| 18 | Hitchhikers on the fungal highway: the helper effect for bacterial migration via fungal hyphae 显示文摘 | Warmink J A Nazir R Corten B van Elsas J D | 2011 | Soil Biology and Biochemistry2011，43，： | 1 |
| 19 | SiGOG: simulated GPS observation generator显示文摘 | ELSA M MAURICIO G CLAUDIO B | 2005 | GPS Solu- tion2005，，9： | 1 |
| 20 | Use of Mild Heat Pre-treatments for Quality Retention of Fresh-cut 'Rocha' Pear显示文摘 | ABREU M SARA B D C ELSA M G | 2003 | Postharvest Biology and Technology2003，30，： | 1 |
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