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| 1 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 2 | Comparison of a new colorimetric assay with the NCCLS broth microdilution method(M27-A) for antifungal drug MIC determination显示文摘 | LI R K ELIE C M CLAYTON G E | 2000 | J Clin Microbiol2000，38，6： | 1 |
| 3 | Are time and temperature the only constraints to the simulation of organic matter maturation显示文摘 | Landais P Michels R Elie M | 1994 | OrgGeochem1994，22，： | 1 |
| 4 | Are time and temperature the only constraints to the simulation of organic matter maturation? 显示文摘 | Landais P Michels R Elie M | 1994 | Org Geochem1994，22，： | 1 |
| 5 | Diumal temperature ahemations (DIF/drop)affect chlorophyll content and chlorophyll a/ chlorophyll b ratio in Melissa officinalis L and Ocimum basilicum L but not in Viola x wittrockiana Gains显示文摘 | Ingunn M V Roar M Eli R | 2003 | Science Horticult2003，97，： | 1 |
| 6 | The use of GPR and VES in delineating a contamination plume in a landfill site:a case study in SE Brazil显示文摘 | Porsani J L Filho W M Elis V R | 2004 | Journal of Applied Geophysics2004，55，： | 1 |
| 7 | Key Issues in Powder Injection Molding显示文摘 | Eli GERMAN R M HENS K F | 1991 | Ceramic Bulletin1991，70，8： | 1 |
| 8 | Are time and temperature the only constraints to the simulation of organic matter matura- tion? 显示文摘 | Landais P Michels R Elie M | 1994 | Organic Geochemistry1994，22，： | 1 |
| 9 | Are time and temperature the only constraints to the simulation of organic matter maturation? 显示文摘 | Landais P Michels R Elie M | 1994 | Organic Geochemistry1994，22，35： | 1 |
| 10 | Understanding of reservoir gas compositions in a natural case using stepwise semi-open artificial maturation显示文摘 | MICHELS R ENJELVIN-RAOULT N ELIE M MANSUY L FAUE P OUDIN J-L | 2002 | Marine and Petroleum Geology2002，19，5： | 1 |
| 11 | Understanding of reservoir gas composition in a natural case using stepwise semi-open artificial maturation显示文摘 | Michels R Enjelvin-Raouh N Elie M | 2002 | Marine and Petroleum Geology2002，19，： | 1 |
| 12 | Captopril in infants for congestive heart failure secondary to a large ventricular left-to-right shunt显示文摘 | Montigny M Davigon A Fouron JC Biron P Foumier A Elie R | 1989 | Am J Cardiol1989，63，9： | 1 |
| 13 | Amantadine hydrochloride treatment in olivopontocerebellar atrophy:a long-term follow-up study显示文摘 | Botez M I Botez-Marquard T Elie R | 1999 | Eur Neurol1999，41，4： | 1 |
| 14 | Are time and temperature the only constraints to the simulation of organic matter maturation?显示文摘 | Landais P Michels R Elie M | 1994 | Organic Geochemistry1994，22，35： | 1 |
| 15 | Are time and temperature the only constraints to the simulation of organic matter maturation显示文摘 | LANDAIS P MICHELS R ELIE M | 1994 | Organic Geochemistry1994，22，35： | 1 |
| 16 | Are time and temperature the only constraints to the simulation of organic maturation?显示文摘 | Landais P Michels R Elie M | 1994 | Organic Geochemistry1994，22，： | 1 |
| 17 | Understanding of reservoir gas compositions in a natural case using stepwise semi-open artificial maturation 显示文摘 | MICHELS R ENJELVIN-RAOULT N ELIE M | 2002 | Marine and Petroleum Geology2002，19，5： | 1 |
| 18 | Are time and temperature the only constraints to the simulation of organic matter maturation? 显示文摘 | Landais P Michels R Elie M | 1994 | Organic Geochemistry1994，22，35： | 1 |
| 19 | A carbon isotope challenge to the snowballEarth显示文摘 | Sansjofre P Ader M Trindade R I F Elie M Lyons J Car- tigny P Nogueira A C R | 2011 | Nature2011，478，： | 1 |
| 20 | A Modified Oregonator Model Exhibiting Complicated Limit Cycle Behavior in a Flow System 显示文摘 | Showalter K Noyes R M Bar - Eli K | 1978 | J Chem Phys1978，69，： | 1 |
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