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| 1 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Short term effects of atorvatatin on c-reactive protein显示文摘 | Riesen W F Engler H Risch M | 2002 | Eur Heart J2002，23，10： | 1 |
| 4 | Short term effects of atorvastatin on C-reactive protein显示文摘 | Riesen WF Engler H Risch M | 2002 | Eur Heart J2002，23，： | 1 |
| 5 | Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats 显示文摘 | Engler M M | 1993 | Prostaglandins Leukotrienes and Essential Fatty Acids1993，49，： | 1 |
| 6 | Immunogenicity of two accelerated hepatitis B vaccination protocols in liver transplant candidates显示文摘 | Engler SH Sauer PW Golling M | 2001 | Eur J Gastroenterol Hepatol2001，13，4： | 1 |
| 7 | The Agrobacterium tumefaciens Ti plasmid as a host vector system for introducing foreign DNA in plant cells显示文摘 | Hernalsteens JP Van Vliet F DeBeuckeleer M Depicker A Engler G Lemmers M Holsters M Van Montagu M Schell J | | 0，，： | 1 |
| 8 | Short- term effects of atorvatatin on c- reactive protein显示文摘 | Riesen W F Engler H Risch M | 2002 | Eur Heart2002，23，： | 1 |
| 9 | Helicobacter pylori γ-glutamyltranspeptidase and vacuolatingcytotoxin promote gastric persistence and immune tolerance显示文摘 | Oertli M Noben M Engler DB | 2013 | Proc Natl Acad Sci U S A2013，110，8： | 1 |
| 10 | Effect of lubrication on the evolution of microstructure and texture during rolling and recrystallization of copper显示文摘 | Huh M Y Cho Y S Engler O | 1998 | Materials Science and Engineering A1998，247，： | 1 |
| 11 | Autocrine actions of macrophage-derived catecholamines on interleukin-1 beta 显示文摘 | Engler K L Rudd M L Ryan J J | 2005 | J Neuroimmunol2005，160，12： | 1 |
| 12 | Noncoupling synthesis of tetrathiafulvalenes显示文摘 | Schumaker R R Lee V Y Engler E M | 1984 | J Org Chem1984，49，3： | 1 |
| 13 | Effect of intermediate annealing on tex- ture, formability and ridging of 17% Cr ferritic stainless steel sheet显示文摘 | Huh M Y Engler O | 2001 | Materials Science and Engineering: A2001，308，12： | 1 |
| 14 | Noncoupling synthesis of tetrathiafulvalene derivatives:systematic modification of BEDT-TTF and TMTTF donors显示文摘 | Schumaker R R Lee V Y Engler E M | 1983 | J Phys Coloq1983，44，3： | 1 |
| 15 | Short-term effects of atorvastatin on C-reactive protein显示文摘 | Riesen W F Engler H Risch M | 2002 | European heart journal2002，23，10： | 1 |
| 16 | Changes in Biochemical Markers after Lower Limb Fractures显示文摘 | Stofel K Engler H Kuster M | | 0，，53： | 1 |
| 17 | Superconductivity above liquid nitrogen temperature:Preparation and properties of a family of perovskite-based superconductors显示文摘 | Engler E M Lee V Y Nazzal A I | 1987 | J Am Ceram Soc1987，109，： | 1 |
| 18 | Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats 显示文摘 | Engler M M Engler M B | 1998 | Prostaglandins Leukotrienes and Essential Fatty Acids1998，59，1： | 1 |
| 19 | Short term effects of atorvastatin on C - reactive protein 显示文摘 | Riesen WF Engler H Risch M | 2002 | Eur Heart J2002，23，： | 1 |
| 20 | Critical evaluation of molecular mechanics显示文摘 | Engler E M Andose J D Schleyer P R J | 1973 | Am Chem Soc1973，95，： | 1 |
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