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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Evaluation of factor V G1691A,prothrombin G20210A,factor Ⅹ Ⅲ V34L,MTHFR A1298C,MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD)panel in south-east region of Turkey显示文摘 | Oztuzcu S Ergun S Ulas M | 2014 | Mol Biol Rep2014，41，6： | 1 |
| 3 | Pickup and Delivery with Split Loads 显示文摘 | Nowak M Ergun O White C C | 2008 | Transportation Science (S1526-5447)2008，42，1： | 1 |
| 4 | “Simulation of open circuit clinker grinding显示文摘 | Benzer H Ergun L Oner M | 2001 | Minerals'' Engineering2001，14，7： | 1 |
| 5 | The Prediction of Corrosion Rates of Reinforcing Steels in Concrete显示文摘 | Yalsyn H Ergun M | 1996 | Concrete Research1996，26，10： | 1 |
| 6 | Detection and typing of human papillomavirus in non-small cell lung cancer显示文摘 | Zafer E Ergun M A Alver G | 2004 | Respiration2004，71，1： | 1 |
| 7 | Shipper collaboration显示文摘 | Ergun O Kuyzu G Savelsbergh M | 2007 | Computer & Operations Research2007，34，6： | 1 |
| 8 | Potential of poultry by-prod- uct meal as a substitute for fishmeal in diets for Black Sea Turbot ScophthlmusMaeoticus: growth and nutrient utilization in winter 显示文摘 | Turker A Yigit M Ergun S | 2005 | The Israeli Jounal of Aquaculture-Bamidgeh2005，57，1： | 1 |
| 9 | Determination of serum bile acids routinely may prevent delay in diagnosis of total parenteral nutrition - induced cholestasis 显示文摘 | Demircan M Ergun O Avanoglu S Yilmaz F Ozok G | 1999 | J Pediatr Surg1999，34，4： | 1 |
| 10 | Aneurysms of the distal anterior cerebral artery:a clinical series 显示文摘 | Sekerci Z Sanli M Ergun R | 2011 | Neurol Neurochir Pol2011，45，2： | 1 |
| 11 | A laboratory study into fracture grouting of fissured Ankara Clay显示文摘 | Tundemir F Ergun M U | 2005 | Innovations in Grouting and Soil Improvement2005，，： | 1 |
| 12 | Protective effect of ambroxol on pulmonary function after cardiopulmonary bypass 显示文摘 | Ulas MM Hizarci M Kunt A Ergun K Kocabeyoglu SS Korkmaz K | 2008 | J Cardiovasc Pharmacol2008，52，6： | 1 |
| 13 | Suppression of ripening and softening of 'Galia' melons by 1-methylcyclopropene applied at preripe or ripe stages of development 显示文摘 | Ergun M Jeong J W Huber D J | 2005 | Hort-Science2005，40，： | 1 |
| 14 | Pitting potential and protection potential of carbon steel for chloride ion and the effectiveness of different inhibiting anions显示文摘 | Ergun M Turan A Y | 1991 | Corros Sci1991，32，10： | 1 |
| 15 | Aneurysms of the distal anterior cerebral artery: a clinical series 显示文摘 | Sekerci Z Sanli M Ergun R | 2011 | Neurol Neuro- chir Pol2011，45，2： | 1 |
| 16 | Endoscopic technique:a new model of subarachnoid hemorrhage in rats显示文摘 | Ergun R Fernandez J Misra M | 2001 | Neurol Res2001，23，6： | 1 |
| 17 | Carboxyl carrying-large uniform latex particles 显示文摘 | Tuncel A Tuncel M Ergun B | 2002 | Colloid Surface A2002，197，123： | 1 |
| 18 | Incorporation of soybean meal and hazelnut meal in diets for Black Sea turbot (Scophthalmus maeoticus) 显示文摘 | Ergun S Yigit M Turker A | 2008 | The Israeli Jounal of Aquaculture-Bamidgeh2008，60，1： | 1 |
| 19 | Capacitive micromachined ultrasonic transducers: Next-generation arrays for acoustic imaging? 显示文摘 | Oralkan O Ergun A S Johnson J A Karaman M Demirci U Kaviani K Lee T H Khuri-Yakub B T | 2002 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2002，49，11： | 1 |
| 20 | Use of experimental design method to investigate metal ion effects in yeast fermentations显示文摘 | Tosun A Ergun M | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
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