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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The early detection of nonpalpable breast carcinoma with needle location显示文摘 | Miller R S Ademan R W Espinosa M H | 1992 | Am Surg1992，58，2： | 1 |
| 3 | MRI features of mucosa-associated lymphoid tissue lymphoma in the breast显示文摘 | ESPINOSA L A DANIEL B L JEFFREY S S | | 0，，01： | 1 |
| 4 | Identification of a gene,MLL,that spans the breakpoint in 11q23 translocations associated with human leukemias显示文摘 | Ziemin-Van Der Poel S McCabe NR Gill HJ Espinosa R 3rd Patel Y Harden A Rubinelli P Smith SD LeBeau MM Rowley JD | | 0，，： | 1 |
| 5 | Characterisation of dusts and sludges generated during stainless steel production in brazilian industries 显示文摘 | Nolasco-Sobrinho P J Espinosa D C R Tenorio J A S | 2003 | Iron- making and steelmaking2003，30，1： | 1 |
| 6 | An overview on the current processes for the recycling of batte - ries 显示文摘 | Espinosa D C R Bemardes A M Teno6rio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 7 | Prognostic significance of macrophage infiltration in leiomyosarcomas 显示文摘 | Lee C H Espinosa I Vrijaldenhoven S | 2008 | Clin Cancer Res2008，14，5： | 1 |
| 8 | Thermal behavior of chro- mium electroplating sludge显示文摘 | ESPINOSA D C R TEN RIO J A S | 2001 | Waste Management2001，21，4： | 1 |
| 9 | Thermal behavior of chromi-um electroplating sludge显示文摘 | ESPINOSA D C R TEN6RI0 J A S | 2001 | Waste Manage2001，21，4： | 1 |
| 10 | The acute respiratory distress syndrome in catastrophic antiphospholipid syndrome:analysis of a series of 47patients显示文摘 | Bucciarelli S Espinosa G Asherson RA | 2006 | Ann Rheum Dis2006，65，1： | 1 |
| 11 | Utilizing full-exchange capacity of zeolites by alkaline leaching: preparation of Fe-ZSM-5 and application in N2O decomposition 显示文摘 | Melian-Cebrera I Espinosa S Groen J C | 2006 | J Catal2006，238，2： | 1 |
| 12 | Cognitive deficiency in mild hypothyroidism显示文摘 | Quijano T D S Delgado C Espinosa S M | 2000 | Neurologia2000，15，5： | 1 |
| 13 | Numerical study of penetration in ceramic targets with a multiple-plane model显示文摘 | Espinosa H D Yuan G Dwivedi S | | 0，，： | 1 |
| 14 | Monitoring of heavy metals in topsoils,atmospheric particles and plant leaves to identify possible contamination sources显示文摘 | Rossini Oliva S Fernandez Espinosa A J | 2007 | Microchemical Journal2007，86，1： | 1 |
| 15 | Development and plas-ticity of the primary visual cortex显示文摘 | ESPINOSA J S STRYKER M P | | 0，，02： | 1 |
| 16 | An overview on the current processes for the recycling of batteries显示文摘 | Espinosa D C R Bernardes A M Tenorio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 17 | Epidemiological and clinical features of hMPV,RSV and RVs infections in young children显示文摘 | Manoha C Espinosa S Aho SL | 2007 | Clin Viro12007，38，3： | 1 |
| 18 | Loss of the lupus au- toantigen Ro52/Trim21 induces tissue inflammation and systemic au-toimmunity by disregulating the IL-23-Th17 pathway 显示文摘 | Espinosa A Dardalhon V Brauner S | 2009 | J Exp Med2009，206，8： | 1 |
| 19 | 查看详情显示文摘 | Duclos S J Jayaraman A Espinosa G P Cooper A S Maines G R | | 0，，： | 1 |
| 20 | Monitoring of heavy metals in topsoils, atmospheric particles and plant leaves to identify possible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microehemical Journal2007，86，： | 1 |
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