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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Antiproliferative Wirkung von genistein auf kuhivierte retinale Pigmentepithelzellen vom Schwein显示文摘 | Krott R Lebek J Grisanti S Esser P Heimann K | 2000 | Olgatlmlmologica2000，214，4： | 1 |
| 3 | Vascular endothelial growth factor induces endothelial fenestrations in vitro显示文摘 | Esser S Wolburg K Wolburg H | 1998 | J Cell Bid1998，140，4： | 1 |
| 4 | Pre operative MRI and surgical management in patients with nonpalpa ble breast cancer:the MONET-randomised controlled trial显示文摘 | Peters NH van Esser S van den Bosch MA | 2011 | Eur J Cancer2011，47，6： | 1 |
| 5 | Cognitive Computing显示文摘 | Modha D S Ananthanarayanan R Esser S K | 2011 | Communications of the ACM (S0001-0782)2011，54，8： | 1 |
| 6 | The Development of the PVD Coating TiAlV as a Commercial Coating for Cutting Tools 显示文摘 | Leyendecker T Lemmer O Esser S | 1991 | Surf Coat Technol1991，，48： | 1 |
| 7 | Preop- erative MRI and surgical management in patients with nonpalpable breast cancer:the MONET-randomised con- trolled trial 显示文摘 | Peters NH van Esser S van den Bosch MA | 2011 | Eur J Cancer2011，47，6： | 1 |
| 8 | Illuminating the evolutionary history of chlamydiae 显示文摘 | Horn M Collingro A Schmitz - Esser S | 2004 | Science2004，304，5671： | 1 |
| 9 | IF-Nalpha activates dormant haematopoietic stem cells in vivo 显示文摘 | ESSERS M A OFFNER S BLANCO-BOSE W E | 2009 | Nature2009，458，： | 1 |
| 10 | The psychometric properties of the St George's Respiratory Questionnaire(SGRQ)in patients with idiopathic pulmonary fibrosis:a literature review显示文摘 | Swigris J J Esser D Conoscenti C S | 2014 | Health Qual Life Outcomes2014，12，1： | 1 |
| 11 | Waterbased crosslinkable surface coatings 显示文摘 | RICHARD J ESSER JAMES E DEVONA DAVE E S | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 12 | The efficacy of radio guided occult lesion localization'(ROLL)versus'wireguided localization'(WGL)in breast conserving surgery for nonpalpable breast cancer:a randomized clinical trial-ROLL study显示文摘 | Esser S Hobbelink MG Peeters PH | 2008 | BMC Surg2008，8，1： | 1 |
| 13 | Dosimetric accuracy andclinical quality of Acuros XB and AAA dose calculation algorithmfor stereotactic and conventional lung volumetric modulated arctherapy plans显示文摘 | KROON P S HOL S ESSERS M | 2013 | Radiat Oncol2013，8，： | 1 |
| 14 | Fractures of the radial head treated by internal fixation:late results in 26 cases显示文摘 | Esser RD Davis S Taavao T | 1995 | J Orthop Trauma1995，，9： | 1 |
| 15 | Progression of coronary atheroscleroeic disease assessed by cine videodensitometry: relation to clinical risk factor 显示文摘 | SHEA S SCIACCA R R ESSER P | 1986 | Am J Cardio1986，57，8： | 1 |
| 16 | IFNalpha activates dormant haematopoietic stem cells in vivo 显示文摘 | Essers MA Offner S Blanco-Bose WE | 2009 | Nature2009，458，7240： | 1 |
| 17 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague S | 2008 | Kidney Int2008，73，11： | 1 |
| 18 | self-administered topical 5% imiquimod for the treatment of common wards and molluscum contagiosum显示文摘 | Hengge UR Esser S Schultewolter T | 2000 | Br J Dermatol2000，143，5： | 1 |
| 19 | Prevalence of cardiac dias- tolic dysfunction in HIV-infected patients: results of the HIV- HEART study显示文摘 | Reinsch N Neuhaus K Esser S etal | 2010 | HIV Clin Trials2010，11，3： | 1 |
| 20 | Preoperative MRI and surgical management in patients with nonpalpable breast cancer:the MONET-randomised controlled trial显示文摘 | Peters N Van Esser S van den Bosch M | 2011 | Euro J Canc- er2011，47，6： | 1 |
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