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| 1 | Hepatic fibrosis: It is time to go with hepatic stellate cell-specifictherapeutic targets显示文摘Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix(ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases. Phenotypic activation of hepatic stellate cells(HSC) plays a central role in the progression of hepatic fibrosis. Retardation of proliferation and clearance of activated HSCs from the injured liver is an appropriate therapeutic strategy for the resolution and treatment of hepatic fibrosis. Clearance of activated HSCs from the injured liver by autophagy inhibitors, proapoptotic agents and senescence inducers with the high affinity toward the activated HSCs may be the novel therapeutic strategy for the treatment of hepatic fibrosis in the near future. | Devaraj Ezhilarasan Etienne Sokal Mustapha Najimi | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 56 |
| 2 | 北大别黄土岭麻粒岩锆石U-Pb离子探针定年显示文摘阴极发光显微结构分析表明 ,北大别黄土岭麻粒岩中存在三种类型的锆石 :原岩锆石、麻粒岩相锆石和残留锆石。对它们分别进行离子探针定年 ,得到黄土岭麻粒岩的原岩年龄约为 2 70 0 Ma、麻粒岩相变质事件的年龄为 2 0 5 2± 10 0 Ma、残留锆石的年龄为约 3.4 Ga。以上研究表明黄土岭麻粒岩为残存的扬子板块的结晶基底 ,而约 3.4 Ga残留锆石的发现 。 | 吴元保 陈道公 夏群科 Etienne DELOULE 程昊 | 2002 | 岩石学报2002，18，3： | 50 |
| 3 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006，12，11： | 39 |
| 4 | 大别山双河超高压榴辉岩中变质锆石:离子探针和微区结构研究显示文摘对南大别双河超高压岩板榴辉岩中锆石进行了阴极发光、喇曼光谱、U- Pb和氧同位素离子探针微区分析。发现大部分锆石具有核边结构 ,其核和边有明显不同的 U ,Th,Pb含量、Th/ U比、2 0 6 Pb/ 2 38U年龄和δ1 8O值。锆石边部具有变质锆石的结构和化学特征 ,核部具有岩浆锆石向变质锆石变化的过渡特征。 17个点 U - Pb同位素分析中大多数为不一致年龄 ,由 14个正向不一致点所构成的不一致线与一致曲线的上、下交点年龄分别为 2 4 89± 2 5和 2 4 8± 16 Ma,它们代表了榴辉岩原岩形成时间和前进变质至峰期变质过程中原岩岩浆锆石重结晶和变质增生作用的时间 ,大别山变质锆石的成因是复杂的 ,它既可以是变质新生锆石 ,呈独立的颗粒或原岩岩浆锆石的增生边 ,也可以是由原岩锆石在固相或流体存在下的重结晶作用形成。不同程度的重结晶作用是超高压条件下双河榴辉岩原岩岩浆锆石发生的主要的物理化学变化 ,它导致锆石中 U、Th、Pb和Th/ | 陈道公 Etienne DELOULE 夏群科 吴元保 程昊 | 2002 | 岩石学报2002，18，3： | 32 |
| 5 | 酸乳发酵凝乳过程中的理化性质和生物活性显示文摘全脂牛奶在室温发酵制作酸乳过程中 ,其酸度随着发酵时间的延续和微生物添加量的增加而上升 ,pH值则逐渐降低 ;而酸乳粘度则随着发酵时间的延续上升达到最高点开始下降 .当微生物添加量为 4 %~ 5% ,发酵 1 2h时 ,酸乳凝乳良好 ,口感适宜 ,活性乳酸菌总数达到 1 0 7数量级 . | 沈辉 Celestin SAB UMUKAMA Etienne NZEYI MANA Felicien NIBRKORO | 2000 | 无锡轻工业学院学报2000，19，5： | 24 |
| 6 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 7 | 北大别片麻岩中锆石U-Pb年龄离子探针初步测定显示文摘对北大别鹿吐石和道士冲二个片麻岩中锆石进行了离子探针 U- Pb年龄测定。二个样品 13个颗粒的 2 0个有效测定点的年龄表明 ,鹿吐石片麻岩主要分布在 2 33~ 394Ma,道士冲片麻岩在 30 7~ 718Ma之间。道士冲片麻岩年龄的一致性程度要高于鹿吐石 ,两个样品均无低于 2 2 0 Ma的年龄信息。由于存在年龄的不一致性 ,这些年龄可能代表了由古老岩浆锆石和三叠纪的超高压变质锆石或者早白垩纪岩浆锆石所代表的混合、增生锆石。 Harker等所认为是典型北大别片麻岩中锆石 ,实际上也是在前寒武纪形成的岩浆锆石基础上叠加白垩纪形成的变质锆石的一种复杂锆石。因此 ,根据锆石年龄分布来看 ,它并不代表这些片麻岩就是在白垩纪时形成的 ,北大别很可能存在二种不同时代的片麻岩。 | 陈道公 Etienne Deloule 夏群科 程昊 | 2000 | 岩石学报2000，16，2： | 23 |
| 8 | 大别山北部黄土岭片麻岩的锆石U-Pb年龄和氧同位素组成:古老的原岩和多阶段历史显示文摘利用阴极发光和离子探针技术,对大别山北部黄土岭片麻岩的锆石进行了内部结构、U-Pb年龄和氧同位素组成的系统分析。黄土岭片麻岩的锆石具有核-幔-边三层结构,核部是原岩的岩浆锆石,形成时代为~2800Ma;幔部是变质重结晶的产物,变质作用的时代为~2000Ma;边部则是在~110Ma从部分熔融体里结晶出来的增生锆石,是受大别山燕山期构造-岩浆事件影响的反映。黄土岭片麻岩和麻粒岩中~2800Ma和~2000Ma的年龄,以及麻粒岩中约3400Ma的残留锆石年龄均可以与扬子崆岭群变质岩对比。由此可以推断,北大别在构造属性上属于扬子板块,扬子与华北板块的缝合线应在北大别以北。锆石的核-幔-边具有不同的氧同位素组成,氧同位素数据表明黄土岭片麻岩的原岩是S型花岗岩,在~2000Ma和~110Ma的事件中都有外来物质(流体或熔体)的加入。 | 夏群科 郑永飞 葛宁洁 Etienne DELOULE | 2003 | 岩石学报2003，19，3： | 22 |
| 9 | Use of mesenchymal stem cells to treat liver fibrosis:Current situation and future prospects显示文摘Progressive liver fibrosis is a major health issue for which no effective treatment is available,leading to cirrhosis and orthotopic liver transplantation.However,organ shortage is a reality.Hence,there is an urgent need to find alternative therapeutic strategies.Cellbased therapy using mesenchymal stem cells(MSCs) may represent an attractive therapeutic option,based ontheir immunomodulatory properties,their potential to differentiate into hepatocytes,allowing the replacement of damaged hepatocytes,their potential to promote residual hepatocytes regeneration and their capacity to inhibit hepatic stellate cell activation or induce their apoptosis,particularly via paracrine mechanisms.The current review will highlight recent findings regarding the input of MSC-based therapy for the treatment of liver fibrosis,from in vitro studies to pre-clinical and clinical trials.Several studies have shown the ability of MSCs to reduce liver fibrosis and improve liver function.However,despite these promising results,some limitations need to be considered.Future prospects will also be discussed in this review. | Silvia Berardis Prenali Dwisthi Sattwika Mustapha Najimi Etienne Marc Sokal | 2015 | World Journal of Gastroenterology2015，21，3： | 22 |
| 10 | 变质锆石拉曼光谱研究——以大别造山带为例显示文摘对大别山的道士冲辉石岩、双河榴辉岩和碧溪岭石榴橄榄岩的锆石进行了激光拉曼探针 ,阴极发光 (CL)观察和U、Th等微量元素的微区分析及U Pb同位素测定 ,发现锆石拉曼光谱波数和半高宽都能指示其蜕晶化程度 ,但对于高度蜕晶化锆石 ,波数已经不再完全适用 ,而只能通过其特征谱峰半高宽来确定。碧溪岭石榴橄榄岩锆石微区微量元素和拉曼探针分析发现 ,半高宽和Th/U比正相关 ,这是由岩浆锆石在变质过程中不同程度的固态重结晶作用造成的 ,其可能曾经遭受过约 2 2 0Ma的热事件扰动。双河榴辉岩锆石则可能遭受了流体参与下的变质重结晶作用的影响。锆石重结晶作用是变质岩中锆石年龄和化学组成变化的主要原因。 | 程昊 陈道公 Etienne Deloule 吴元保 | 2002 | 矿物学报2002，22，4： | 13 |
| 11 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhf6un0pvovpkn6kuk.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 12 | 东方遇见西方:增龄性骨骼肌肉疾病的临床实践和策略显示文摘健康老龄化是指人在维持良好身体功能、保证生活质量前提下的衰老过程。这个过程能否实现取决于机体固有能力,一方面包括心理、生理能力,另一方面包括机体所处环境以及二者的相互作用。在老龄化进程中,骨骼肌肉健康是维持老年人身体功能的重要条件。全球肌少症、骨质疏松症和骨关节炎等老龄化相关的骨骼肌肉疾病及机体失能所致的负担正在增加,因此随着人口老龄化的加剧,防治这类疾病也尤为重要。以此为契机,中华医学会、中华医学会骨质疏松和骨矿盐疾病分会、欧洲骨质疏松和骨关节炎临床经济学会联合开设论坛,共同探讨增龄性肌肉骨骼疾病的现行临床诊治策略。本次会议邀请了中国和欧洲的专家到场,分享这3种疾病的临床诊治经验;双方通过经验交流、讨论异同以取长补短,从而实现对疾病的更佳防治,维持老年人的自身能力、延缓老龄化带来的身体功能退化。展望未来,希望双方经验及最佳临床实践的交流能推进全球战略,以减轻肌肉骨骼疾病的负担,促进符合个体化需求的健康老龄进程。 | 夏维波 Cyrus Cooper 李梅 徐苓 Rene Rizzoli 朱梅 林华 John Beard 丁悦 余卫 Etienne Cavalier 章振林 John A.Kanis 程群 王秋梅 Jean-Yves Reginster 冯亦鸣(翻译) | 2019 | 中华骨质疏松和骨矿盐疾病杂志2019，12，5： | 13 |
| 13 | The multiple universes of estrogen-related receptor a and Y in metabolic control and related diseases显示文摘The identification of the estrogen-related receptors (ERRs) as the first orphan nuclear receptors ignited a new era in molecular endocrinology, which led to the discovery of new ligand-dependent response systems. Although ERR subfamily members have yet to be associated with a natural ligand, the characterization of these orphan receptors has demonstrated that they occupy a strategic node in the transcriptional control of cellular energy metabolism. In particular, ERRs are required for the response to various environmental challenges that require high energy levels by the organism. As central regulators of energy homeostasis, ERRs may also be implicated in the etiology of metabolic disorders, such as type 2 diabetes and metabolic syndrome. Here, we review the recent evidence that further highlights the role of ERRs in metabolic control, particularly in liver and skeletal muscle, and their likely involvement in metabolic diseases. Consequently, we also explore the promises and pitfalls of ERRs as potential therapeutic targets. | Etienne AUDET-WALSH Vincent GIGUIERE | 2015 | Acta Pharmacologica Sinica2015，36，1： | 11 |
| 14 | Retrograde intrarenal surgery:An expanding role in treatment of urolithiasis显示文摘During the past 3 decades,the surgical management of kidney stones has undergone many technological advances and one is the development of the flexible ureteroscopy.The development of this instrument as well as ancillary equipment such as baskets,graspers,and others,and improvements in lithotripsy with Holmium:YAG laser have led to expand its indications with diagnostic and therapeutic management of medical issues of the upper urinary tract such as urolithiasis and urothelial tumors.The objective of this review is to describe its indications and results in the different scenarios for the treatment of urinary stones. | Maria Rodriguez-Monsalve Herrero Steeve Doizi Etienne Xavier Keller Vincent De Coninck Olivier Traxer | 2018 | Asian Journal of Urology2018，5，4： | 11 |
| 15 | 碧溪岭岩体中石榴橄榄岩的锆石显微结构及离子探针定年显示文摘对碧溪岭岩体中石榴橄榄岩的锆石进行了BSE和CL显微结构分析 ,并在此基础上用离子探针进行了锆石微区U Pb定年。锆石CL图像显示其有明显的核边结构 ,核部具岩浆锆石 ,边部是变质增生锆石的特征。结合锆石的外形特征认为 ,边部的变质锆石是在超高压变质作用中重结晶形成的。离子探针分析结果在一致曲线图中构成不一致线 ,得到上下交点年龄分别为 82 4±39Ma和 2 5 4± 38Ma。结合CL图像认为上交点 82 4± 39Ma的年龄代表其原岩形成年龄 ,下交点2 5 4± 38Ma为其超高压变质作用的年龄。另有少量较老年龄的捕虏晶锆石 。 | 吴元保 陈道公 程昊 Etienne Deloule 夏群科 | 2001 | 高校地质学报2001，7，3： | 10 |
| 16 | 7475铝合金板材的各向异性疲劳性能显示文摘基于高周疲劳弯曲实验,研究了航空用铝合金板材Al7475-T3的各向异性疲劳行为.结果表明:轧制后形成了扁平长条状结构的7475-T3铝合金具有良好的耐疲劳损伤性能.在室温弯曲加载条件下,从3个平面(S-T,S-L,T-L)截取的光滑试样的疲劳极限最高可达200 MPa,除在T-L面上表现为各向同性外,其余两面的疲劳性能均表现出各向异性.采用以最弱链接理论为基础的概率疲劳准则,分析了铝合金板材中疲劳裂纹产生的可能性,但模拟结果与实际相差较远.综合考虑晶粒有效滑移长度和夹杂物尺寸两因素,对疲劳极限的影响进行模型计算,得出的Kitagawa曲线与实际情况比较吻合. | 肖骥 Etienne Pessard 王敏 Daniel Cuillerier | 2011 | 上海交通大学学报2011，45，11： | 10 |
| 17 | 电能表计量无功功率的方法显示文摘总结了电能表常用的三种无功功率测量方法的定义,并根据IEC1268标准的技术条件给出了三种无功测试方法测量误差的试验数据,从而得出了低通滤波器方法测量无功功率是一种较好的方法的结论。 | Etienne Moulin | 2004 | 电测与仪表2004，41，4： | 10 |
| 18 | The Global Boundary Stratotype Section and Point for the base of the Danian Stage (Paleocene, Paleogene,"Tertiary", Cenozoic) at El Kef, Tunisia—Original definition and revision显示文摘 | Eustoquio Molina Laia Alegret Ignacio Arenillas José A. Arz Njoud Gallala Jan Hardenbol Katharina von Salis Etienne Steurbau Noeel Vandenberghe Dalila Zaghbib-Turki | 2006 | Episodes2006，29，4： | 9 |
| 19 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 20 | 山东蓬莱新生代岩石圈地幔的异常锂同位素组成:橄榄岩包体的离子探针分析显示文摘应用离子探针技术对山东蓬莱新生代玄武岩中橄榄岩包体的主要组成矿物进行了原位测定,结果显示了强烈偏离正常地幔矿物组成和平衡的Li含量和同位素比值。橄榄石、斜方辉石和单斜辉石的Li含量和δ7Li分别为(2.0~10.4)×10-6,(2.8~23.8)×10-6和(3.3~59.7)×10-6;-28.6‰~+0.5‰,-12.7‰~+12.8‰和-41.5‰~+22.6‰。这种强烈的非平衡体系反映了最近强烈和复杂的地幔交代作用。辉石的高Li(~60×10-6)和δ7Li(~+20‰)反映了最近富Li地幔熔体/流体的特征,而橄榄石的中等Li富集(<5×10-6)和强烈的δ7Li亏损(~-20‰)则可能记录了更早一期低δ7Li的地幔交代。同位素剖面的扩散反演以及Li强烈富集与LREE相对亏损之间的解耦显示了两期地幔交代作用的短暂性和近期性。因此,我们认为华北东部克拉通上地幔中存在与再循环有关的锂同位素异常组分,它们的形成应该与中生代以来太平洋板块向东亚大陆下的俯冲有关.这些组分能够在地幔中较长的保存直至最近被热扰动所释放,并被橄榄岩包体所记录。 | 李佩 夏群科 Etienne DELOULE | 2012 | 高校地质学报2012，18，1： | 9 |
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