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1Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries.Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho 2019World Journal of Gastroenterology2019,25,26:3
2Nitric oxide destruction during coal and char oxidation under pulverized-coal combustion conditions显示文摘MOLINA A EDDINGS E G PERSHING D W SAROFIM A F 2004Combust Flame2004,136,:1
3Human breast cancer specimens:diffraction-enhanced imaging with histologic correlation-improved conspicuity of lesion detail compared with digital radiography显示文摘 Johnston RE Chapman D 2000Radiology2000,214,3:1
4Carbon membraneds from precursors containing low-carbon residual polymers显示文摘Linkov Vhdimir M Sanderson Ron D Jacobs Ed P 1994Polymer International1994,35,3:1
5Bioinversion of R-flurbiprofen to S-flurbiprofen at various dose levels in rat,mouse,and monkey显示文摘Leipold DD Kantoci D Murray ED Jr 2004Chirality2004,16,6:1
6Differential regulation of superoxided ismutases in plants exposed to nvironm ental stress显示文摘TSANG ED WTBC HEROUART D VAN CAMP W 1991Plant Cell1991,,3:1
716-Aryloxypros- taglandins :a new class of potent luteolytic agent显示文摘Binder D Bowler J Brown ED 1974Pros- taglandins1974,6,1:1
8Innate lymphoid ceils: balancing immunity, inflammation, and tissue repair in the intestine 显示文摘Tait Wojno ED Artis D 2012Cell Host Microbe2012,12,4:1
9Char nitrogen conversion: implications to emissions from coal-fired utility boilers 显示文摘Molina A Eddings E G Pershing D W 2000Progress in Energy and Combustion Science2000,26,46:1
10Exon skipping of AGAMOUS homolog PrseAG in developing double flowers of Prunus lannesiana (Rosaceae)显示文摘Liu Z Zhang D Liu D et ed 2013Plant Cell Reports2013,32,2:1
11Low diagnostic yield of elective coronary angiography显示文摘Patel MR Peterson ED Dai D 2010N Engl J Med2010,362,:1
12Fundamentals of neurogastroenterology: basic science 显示文摘Grundy D Chaer ED Aziz Q 2006Gastroenterol2006,130,5:1
13Arerial switch operation with a single coronary artery显示文摘Scheule AM Zurakowski D Blume ED et ai 2002J Thorac Cardiovasc Surg2002,123,:1
14Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis 显示文摘Kharasch ED Hankins D Mautz D 1996Lancet1996,347,9012:1
15Radial forearm flap donor-site complications and morbidity: A prospective study 显示文摘Richardson D Fisher SE Vaughan ED 1997Plast Reconstr Surg1997,99,1:1
16Serum vitamin D,parathyroid hormone levels,and carotid atherosclerosis 显示文摘Reis JP von Muhlen D Michos ED 2009Atherosclerosis2009,207,2:1
17FOXL2 and BPES: Mutational Hotspots, Phenotypic Variability, and Revision of the Genotype-Phenotype Correlation显示文摘Baere ED Beysen D Oley C 2003Am J Hum Genet2003,72,:1
18Inhaled azithromycin therapy显示文摘Hickey AJ Lu D Ashley ED 0,,01:1
19Comel-Netherton syn- drome defined as primary immunodeficiency 显示文摘Rennet ED Hartl D Rylaarsdam S 2009J Allergy Clin Immunol2009,124,3:1
20A 64 - year- old man with joint swelling and an abnormal chest radiograph 显示文摘Sergew A Merrick D Chan ED 2008Chest2008,133,3:1
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