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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis显示文摘AIM: To demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells(CSCs) of gastric mucosa in an animal model. METHODS: In this study we investigated the effects of aging and Helicobacter pylori(H. pylori) inflammation as a model for inflammation induced carcinogenesis in human and rat gastric mucosa samples. In aging studies, we compared 4-mo old(young) with 22 mo(aged) old Fischer-344 rats. For human studies, gastric biop-sies and resection specimens representing normal mucosa or different stages of H. pylori gastritis and gastric adenocarcinomas were used for determining the expression of stem cell markers CD166, ALDH1 and LGR5. In addition we performed immunofluorescent double labeling for B-catenin and Lgr5 in both rat and human gastric tissues to examine the status of Wnt signaling in these cells. RESULTS: CSC markers ALDH1, LGR5, and CD166 were expressed in very low levels in normal human gastric mucosa or young rat gastric mucosa. In contrast, level of expression for all three markers significantly increased in H. pylori gastritis and gastric adenocarcinomas as well as in normal gastric mucosa in aged rats. We also observed cytoplasmic B-catenin staining in both aged rat and human H. pylori inflamed gastric mucosa, which were found to be colocalized with Lgr5 immunoreactive cells. The increased number of ALDH1, CD166 and LGR5 positive cells in H. pylori gastritis indicates that increased number of stem-like cells in gastric mucosa is an early event, and may constitute an important step in the progression to neoplasia. CONCLUSION: Our observation of the age-related increase in cancer stem/stem-like cells in the gastric mucosa may explain the increased incidence of gastric cancer during aging. Combination of aging and H. pylori infection may have additive effects in progression to neoplasia. | Edi Levi Paula Sochacki Nabiha Khoury Bhaumik B Patel Adhip PN Majumdar | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 5 |
| 3 | Parallel machine scheduling with additional resources: Notation, classification, models and solution methods显示文摘 | Edis E B Oguz C Ozkarahan I | 2013 | European Journal of Operational Research2013，230，3： | 1 |
| 4 | Melt-spun non-circular carbon fibers显示文摘 | EDIE D D FOX N K BARNETT B C | 1986 | Carbon1986，24，： | 1 |
| 5 | Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells显示文摘 | Atsushi N Edi B Marianne K | 1995 | J Biol Chem1995，270，31： | 1 |
| 6 | Parallel machine scheduling with flexible resources显示文摘 | Edis E B Oguz C | 2012 | Computers & Industrial Engineering2012，63，2： | 1 |
| 7 | The thermal conductivity of ribbon-shaped carbon fibers显示文摘 | Gallego N C Edie D D Nysten B | 2000 | Carbon2000，38，7： | 1 |
| 8 | Determination and mitigation of ammonia loss from urea applied to winter wheat with N-(n-butyl) thiophosphorictriamide显示文摘 | TURNER D A EDIS R B CHEN D | 2010 | Agriculture Ecosystems & Environment2010，137，34： | 1 |
| 9 | Lymphoma of the breast: Pathology and clinical behavior 显示文摘 | Edi B Naney LH | 1999 | Seminars in Oncology1999，26，3： | 1 |
| 10 | Determination and mitigation of ammonia loss from urea applied to winter wheat with N-( n-bu- tyl) thiophosphorictriamide 显示文摘 | Turner D A Edis R B Chen D | 2010 | Agriculture Ecosystems and Envi- ronment2010，137，： | 1 |
| 11 | Anal Chim Acta显示文摘 | Maj edi S M Kelly B C Lee H K | 2013 | 789 : 472013，789，： | 1 |
| 12 | Lymphomas of the breast : Parhology and clinical behavior显示文摘 | Edi B Namcy L | 1999 | Seminars in Oncology1999，26，3： | 1 |
| 13 | BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia显示文摘 | EDI A ZEHNBAUER B A COLLECTOR M I | 1993 | Blood1993，81，： | 1 |
| 14 | Settlement of Municipal Refuse 显示文摘 | Edi T B Ranguette V J Wuellner W W | 1990 | Geotechnics of Waste Fills: Theory and Practice1990，5，： | 1 |
| 15 | The thermal con- ductivity ribbon-shaped carbon fibers显示文摘 | Callego N C Edie D D Nysten B | 2000 | Carbon2000，38，7： | 1 |
| 16 | Hypoxia induces vascular endothelial growth factor in cultured human endothelial celts显示文摘 | Atsushi N Edi B Marianne K | 1995 | J Biol Chem1995，270，31： | 1 |
| 17 | Advanced Interpolation Techniques for NC Machines显示文摘 | ALI I QUNN N | 1993 | J of Engineer for Industry1993，，11： | 1 |
| 18 | The thermal conductivity of ribbon shaped carbon fibers显示文摘 | Gallego N C Edie D D Nysten B | 2000 | Carbon2000，38，7： | 1 |
| 19 | The thermal conductivity ot ribbon-shaped carbon fibers显示文摘 | Gallego N C Edie D D Nysten B | 2000 | Carbon2000，38，7： | 1 |
| 20 | lymphoma of the breast: Pathology and clinical behavior显示文摘 | Edi B Naney LH | 1999 | Seminars in Oncology1999，26，3： | 1 |
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