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| 1 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | Hybrid Active Filtering of Harmonic Currents in Power Systems显示文摘 | Rastogi M Mohan N Edris A A | 1995 | IEEE Trans on PD1995，10，4： | 1 |
| 3 | Operation of the unified power flow controller (UPFC) under practical constraints显示文摘 | Schauder C D Hamai D M Edris A | 1998 | IEEE Trans on PD1998，13，2： | 1 |
| 4 | Hybrid-active filtering of harmonic currents in power systems显示文摘 | Rastogi M Mohan N Edris A A | 1995 | IEEE Trans on Power Delivery1995，10，4： | 1 |
| 5 | Effects of Surface Modification on the Mechanical and Structural Properties of Nanofibrous Poly (e-caprolaetone)/Forsterite Scaffold for Tissue Engineering Applications 显示文摘 | Kharaziha M Fathi M H Edris H | 2013 | Materials Science and Engineering: C2013，33，8： | 1 |
| 6 | Eigen analysis of series compensation schemes reducing the potential of subsynchronous resonance 显示文摘 | Iravani M R Edris A A | 1995 | IEEE Trans onPower Systems1995，10，2： | 1 |
| 7 | The potential use of volt-age-sourced converter-based back-to-back tie in load resto-rations显示文摘 | Noroozian M Edris A Kidd D | 2003 | IEEE Transaction on Industry Applications2003，18，4： | 1 |
| 8 | Hybrid Active Filtering of Harmonic Currents in Power Systems显示文摘 | RASTOGI M MOHAN N EDRIS A A | 1995 | IEEE Trans on Power Delivery1995，10，4： | 1 |
| 9 | Recovery of volatile aroma components from aqueous waste streams using an activated carbon column显示文摘 | EDRIS A E GIRGIS B S FADEL H M | | 0，，02： | 1 |
| 10 | The Potemial Use of Voltage-sourced Converter-based Back-to-back Tie in Load Restorations显示文摘 | Noroozian M Edris A A Kidd D | 2003 | IEEE Trans on Power Delivery2003，，18： | 1 |
| 11 | Softening the blow of disturbances 显示文摘 | CLARK H EDRIS A GASSEIR M | 2008 | IEEE Power Energy Magazine2008，6，1： | 1 |
| 12 | The potential use of voltage sourced converter based back-to-back tie in load restoration 显示文摘 | Nomozian M Edris A Kidd D | 2003 | IEEE Trans on Power Delivery2003，18，4： | 1 |
| 13 | Hybrid-active filtering of harmonic current in power systems显示文摘 | Rastogi M Mohan N Edris A | 1995 | IEEE Trans on Power Delivery1995，10，4： | 1 |
| 14 | Hybrid active filtering of harmonic currents in power systems 显示文摘 | Rostogi M Mohan N Edris A | 1995 | IEEE Transaction on Power Delivery1995，10，4： | 1 |
| 15 | Life time of new SYSZ thermal barrier coatings produced by plasma spraying method under thermal shock test and high temperature treatment 显示文摘 | ESTARIKI M R L RAZAVI R S EDRIS H POURBAFRANY M JAMALI H GHASEMI R | 2014 | Ceramics International2014，，： | 1 |
| 16 | Effect of the composition of hydroxyapatite/bioactive glass nanocomposite foams on their bioactivity and mechanical properties显示文摘 | Ghomi H Fathi M Edris H | 2012 | Mater Res Bull2012，47，11： | 1 |
| 17 | Operation of the unified power flow controller (UPFC) under practical constraints显示文摘 | Schauder C D Hamai D M Edris A | 1998 | IEEE Trans on Power Delivery1998，13，2： | 1 |
| 18 | Investigation of the volatile aroma components of garlic leaves essential oil, possibility of utilization to enrich garlic bulb oil 显示文摘 | Edris A E Fadel H M | 2002 | Eur Food Res Technol2002，214，： | 1 |
| 19 | Effect of Sb ions on the morphology of chemical bath-deposited ZnO films and appli- cation to nanoporous solar cells 显示文摘 | Kedem N Edri E Kokotov M | 2010 | Cryst Growth Des2010，10，： | 1 |
| 20 | Data integration exchange显示文摘 | KEZUNOVIC M ABUR A EDRIS A | 2004 | IEEE Power & Energy Magazine2004，13，3： | 1 |
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