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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 3 | ^238U,^234U and ^232Th in sea water显示文摘 | Chen J H Edwards R L Wasserburg G J | 1986 | Earth and Planetary Science Letters1986，，80： | 1 |
| 4 | A test of climate, sun, and culture relationships from an 1 810 year Chinese ca- ve record显示文摘 | Zhang P Z Cheng H Edwards R L | 2008 | Science2008，322，： | 1 |
| 5 | Timing, duration, and transitions of the last interglacial asian monsoon 显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，： | 1 |
| 6 | ^238U-^234U -^230Th-^232Th systematics and the precise measurement of time over the past 500 000 years显示文摘 | Edwards R L Chen J H Wasserburg G J | 1986 | Earth and Planetary Science Letters1986，81，： | 1 |
| 7 | The application of a piezoelectric bar gauge to shock tube studies显示文摘 | Edwards D H Davies L Lawrence T R | 1964 | J Sci Instrum1964，64，： | 1 |
| 8 | The holocene asian monsoon: links to solar changes and North Atlantic climate 显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，： | 1 |
| 9 | The half-lives of uranium-234 and thorium-230显示文摘 | Cheng H Edwards R L Hoff J A | 2000 | Chem Geol2000，169，： | 1 |
| 10 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control:The Diabetes Stages of Change(Disc)Study显示文摘 | Jones H Edwards L Vallis T M | | 0，，3： | 1 |
| 11 | A decade of raman spectroscopy in art and archaeology 显示文摘 | VANDENABEELE P EDWARDS H G M MOENS L | 2007 | Chemical Reviews2007，107，： | 1 |
| 12 | A test of climate, sun,and culture relationships from an 1810-year Chinese cave record显示文摘 | Zhang P Z Cheng H Edwards R L | 2008 | Science2008，322，： | 1 |
| 13 | Inert Anodes and Other Technology Changes in the Aluminum Industry-The Benefits, Challenges and Impact on Present Technology 显示文摘 | EDWARDS L KVANDA H | 2001 | JOM2001，53，5： | 1 |
| 14 | Timing,duration,and transitions of the last interglacial Asian monsoon显示文摘 | Yuan D X Cheng H Edwards R L | 2004 | Science2004，304，5670： | 1 |
| 15 | High resolution characterization of the asian monsoon between 146 0013 and 99 0013 years B P from Dongge Cave, China and global correlation of events surrounding Termination Ⅱ 显示文摘 | Kelly M J Edwards L R Cheng H | 2006 | Palaeogeography Palaeeclimatology Palaeoecology 20062006，236，： | 1 |
| 16 | Image segmentation from scale and rotation invariant texture features from the double dyadic dual-tree complex wavelet transform显示文摘 | Edward H S L Pickering M R Frater M R | | 0，，01： | 1 |
| 17 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 18 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | Changes in diabetes self - care behaviors make a difference in glycemic control: the diabetes stages of change (DSC) study 显示文摘 | Jones H Rossi JS Edwards L | 2003 | Diabetes Care2003，26，： | 1 |
| 20 | The Holocene Asian Monsoon: links to solar changes and North Atlantic climate显示文摘 | Wang Y J Cheng H Edwards R L | 2005 | Science2005，308，： | 1 |
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