|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 绿色荧光蛋白——发现、表达和发展显示文摘由于在发现和研究绿色荧光蛋白方面做出的贡献,日本科学家下村修(Qsamu Shimomura)、美国科学家马丁·沙尔菲(Martin Chalfie)和美籍华裔科学家钱永健(Roser Y Tsien)共同获得了2008年度的诺贝尔化学奖。 | Mns Ehrenberg 罗文新 夏宁邵 | 2008 | 生物物理学报2008，24，6： | 16 |
| 2 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 3 | Probing thermally-induced structural evolution during the synthesis of layered Li-, Na-, or K-containing 3d transition-metal oxides显示文摘Layered alkali-containing 3d transition-metal oxides are of the utmost importance in the use of electrode materials for advanced energy storage applications such as Li-,Na-,or K-ion batteries.A significant challenge in the field of materials chemistry is understanding the dynamics of the chemical reactions between alkali-free precursors and alkali species during the synthesis of these compounds.In this study,in situ high-resolution synchrotron-based X-ray diffraction was applied to reveal the Li/Na/K-ion insertion-induced structural transformation mechanism during high-temperature solid-state reaction.The in situ diffraction results demonstrate that the chemical reaction pathway strongly depends on the alkali-free precursor type,which is a structural matrix enabling phase transi-tions.Quantitative phase analysis identifies for the first time the decomposition of lithium sources as the most critical factor for the formation of metastable intermediates or impurities during the entire process of Li-rich layered Li[Li_(0.2)Ni_(0.2)Mn_(0.6)]O_(2) formation.Since the alkali ions have different ionic radii,Na/K ions tend to be located on prismatic sites in the defective layered structure(Na_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2) or K_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2))during calcination,whereas the Li ions prefer to be localized on the tetrahedral and/or octahedral sites,forming O-type structures. | Weibo Hua Xiaoxia Yang Nicola PMCasati Laijun Liu Suning Wang Volodymyr Baran Michael Knapp Helmut Ehrenberg Sylvio Indris | 2022 | eScience2022，2，2： | 2 |
| 4 | Do Tournaments Have Incentive Effects? 显示文摘 | Ehrenberg R G Bognanno M L | 1990 | Journal of Political Economics1990，98，6： | 1 |
| 5 | Assessing the relative importance of compaction processes and cementation to reduction of porosity in sandstone:Compaction and porosity evolution of Pliocene sandstone,Ventura basin,California显示文摘 | Ehrenberg S N | 1989 | AAPG Bulletin1989，73，10： | 1 |
| 6 | Problem-based learning in clinicalnursing education:integrating theory and practice显示文摘 | Ehrenberg AC Haggblom M | 2007 | Nurse EducPract2007，7，2： | 1 |
| 7 | Petroleum reservoir porosity versus depth:Influence of geological age显示文摘 | EHRENBERG S N NADEAU P H | 2009 | Aapg Bulletin2009，93，10： | 1 |
| 8 | Studying Ourselves: The Academic Labor Market显示文摘 | Ehrenberg R | 2003 | Journal of Labor Economics2003，，21： | 1 |
| 9 | Effects of thoracic epidural analgesia on glucose homeostasis after cardiac surgery in patients with and without diabetes mellitus 显示文摘 | Anderson RE Ehrenberg J Barr G | 2005 | Eur J Anaesthesiol2005，22，7： | 1 |
| 10 | High-field magnetic structure and critical phenomena in MnWO4 显示文摘 | EHRENBERG H WEITZEL H THEISSMANN R | 2000 | Phys B2000，，： | 1 |
| 11 | Kaolinized,potassium-leached zones at the con- tacts of the Garn Formation,Haltenbanken,mid-Norwegian continental shelf显示文摘 | Ehrenberg S N | 1991 | Marine and Petroleum Geology1991，8，3： | 1 |
| 12 | Understanding brand performance measures:using dirichlet benchmarks显示文摘 | Ehrenberg A S C Uncles M D Goodhardt G J | 2004 | Journal of Business Research2004，57，： | 1 |
| 13 | Medium- dependent control of the bacterial growth rate显示文摘 | Ehrenberg M Bremer H Dennis P P | 2013 | Biochemie2013，95，4： | 1 |
| 14 | Influence of depositional sand quality and dia- genesis on porosity and permeability:Examples from Brent Group reservoirs,northern North Sea显示文摘 | Ehrenberg S N | 1986 | Journal of Sedimen- tary Research1986，67，1： | 1 |
| 15 | Intentions-to-buy and Claimed Brand Usage显示文摘 | BIRD M EHRENBERG A S C | 1966 | Operations Research Quarterly1966，17，1： | 1 |
| 16 | Estimation of cancer risk caused by environmental chemicals based on in vivo dose measurement显示文摘 | Tornqvist M Ehrenberg L | 2001 | J Environ Patho Toxico Oncology2001，20，： | 1 |
| 17 | Formation of diagenetic illite in sandstones of the Garn Formation,Haltenbanken area,mid-Norwegian continental shelf显示文摘 | Ehrenberg S N Nadeau P H | 1989 | Clay Minerals1989，24，2： | 1 |
| 18 | Preservation of anomalously high poro- sity in deeply buried sandstones by grain- coating: Exam- ple from the Norwegian Continental Shelf显示文摘 | Ehrenberg S N | 1993 | AAPG Bul- letin1993，77，7： | 1 |
| 19 | Evaluation of the genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide 显示文摘 | Ehrenberg L Hiesche KD Osterman-Golkar S | 1974 | Mutat Res1974，24，： | 1 |
| 20 | Preservation of anomalously high porosity in deeply buried sandstones by grain-coating chlorite:examples from the Norwegian Continental Shelf显示文摘 | Ehrenberg S N | 1993 | AAPG Bulletin1993，77，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员