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| 1 | Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats显示文摘AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) injury.METHODS:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,i.p.given 15 min prior to gastric ischemia) were recruited.Gastric injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 min.Gastric tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and Ang-2.Vascular endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue homogenate.To assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and immunostained.Another set of experiments was run to study vascular permeability of the stomach using Evan's blue dye.RESULTS:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P < 0.05),VEGF(36.87 ± 2.71 pg/100 mg protein vs 48.4 ± 6.53 pg/100 mg protein,P < 0.05) and MCP-1 tissue level(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced congestion.Ang-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated animals.The administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were seen.CONCLUSION:AGM protects the stomach against I/R injury by reducing vascular permeability and inflammation.This protection is possibly mediated by Akt/PI3K. | Abeer A Al Masri Eman El Eter | 2012 | World Journal of Gastroenterology2012，18，18： | 4 |
| 2 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 3 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 4 | Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG),myelin associated glycoprotein and Nogo-A显示文摘 | Wright KT El Masri WE Osman A | | 0，，02： | 1 |
| 5 | Hyperspectral imaging for nondestructive determination of some quality attributes for strawberry显示文摘 | El MASRY G WANG N El SAYED A | 2007 | Journal of Food Engineering2007，81，： | 1 |
| 6 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 7 | Concise review:Bone marrow for the treatment of spinal cord injury:mechanisms and clinical applications显示文摘 | Wright KT El Masri W Osman A | | 0，，02： | 1 |
| 8 | Immediate effect of balloon valvuloplasty on hemostatic changes in mitral stenosis显示文摘 | Zaki A Salama M El Masry M | 2000 | Am J Cardiol2000，85，3： | 1 |
| 9 | Hyponatremia after acute spinal injury 显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 10 | Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A 显示文摘 | Wright KT El Masri W Osman A | 2007 | Biochem Biophys Res Commun2007，354，2： | 1 |
| 11 | Immediate effect of balloon valvuloplasty on hemostatic changes in mitral stenosis显示文摘 | Zaki A Salama M El Masry M | 2000 | Am J Cardiol2000，85，3： | 1 |
| 12 | Immediate effect of ballon valvuloplasty on hemostastic changes in mitral stenosis 显示文摘 | Zaki A Salama M El Masry M | 2000 | Am J Cardiol2000，85，3： | 1 |
| 13 | Post-traumatic syringomyelia显示文摘 | el Masry WS | 1994 | Paraplegia1994，32，11： | 1 |
| 14 | Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG),myelin associated glycoprotein and Nogo-A显示文摘 | Wright KT El Masri W Osman A | 2007 | Biochemical and Biophysical Research Communications2007，354，： | 1 |
| 15 | Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG),myelin associated glycoprotein and Nogo-A显示文摘 | Wright KT El Masri W Osman A | 2007 | Biochem Biophys Res Commun2007，354，2： | 1 |
| 16 | Multilevel spinal injuries, incidence, distribution and neurologi- cal patterns显示文摘 | Gupta A el Masri WS | 1989 | J Bone Joint Surg Br1989，71，4： | 1 |
| 17 | Concise review:Bone marrow for the treatment of spinal cord injury:Mechanisms and clinical applications显示文摘 | Wright KT El Masri W Osman A | 2011 | Stem cells (Dayton Ohio)2011，29，： | 1 |
| 18 | The Claus reaction:Effect of forced feed composition cycling 显示文摘 | Masry H A EL | 1985 | Appl Catal1985，16，： | 1 |
| 19 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 20 | Bone marrow stromal cellsstimulate neurite outgrowth over neural proteoglycans (CSPG),myelin associated glycoprotein and Nogo-A显示文摘 | Wright KT El Masri W Osman A | | 0，，02： | 1 |
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