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| 1 | Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women显示文摘AIM: To investigate the frequency and timing of post-partum chronic hepatitis B virus(HBV) reactivation and identify its pre-partum predictors. METHODS: Forty-one hepatitis B e antigen(HBe Ag)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28 th and the 32 nd week of gestation. Subjects were re-evaluated at 3-mo intervals during the first post-partum year and every 6 mo during the following years. HBV DNA was determined using real-time reverse transcription polymerase chain reaction(Cobas Taq Man HBV Test) with a lower detection limit of 8 IU/m L. Post-partum reactivation(PPR) was defined as abnormal alanine aminotransaminase(ALT) levels and HBV DNA above 2000 IU/m L. RESULTS: Fourteen out of 41 women(34.1%) had prepartum HBV DNA levels > 2000 IU/m L, 18(43.9%) had levels < 2000 IU/m L and 9(21.9%) had undetectable levels. Fourteen women were lost to follow-up(failure to return). PPR occurred in 8 of the 27(29.6%) women evaluated, all within the first 6 mo after delivery(5 at month 3; 3 at month 6). Five of the 6(83.3%) women with pre-partum HBV DNA > 10000 IU/m L exhibited PPR compared with 3 of the 21(14.3%) women with HBV DNA < 10000 IU/m L(two with HBV DNA > 2000 and the third with HBV DNA of 1850IU/m L), P = 0.004. An HBV DNA level ≥ 10000 IU/m L independently predicted post-partum HBV infection reactivation(OR = 57.02, P = 0.033). Mean pre-partum ALT levels presented a non-significant increase in PPR cases(47.3 IU/L vs 22.2 IU/L, respectively, P = 0.094).CONCLUSION: In the present study, PPR occurred in approximately 30% of HBe Ag-negative pregnant women; all events were observed during the first semester after delivery. Pre-partum HBV DNA level > 10000 IU/m L predicted PPR. | Ioannis Elefsiniotis Elena Vezali Dimitrios Vrachatis Sofia Hatzianastasiou Stefanos Pappas George Farmakidis Georgia Vrioni Athanasios Tsakris | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 2 | HBeAg negative serological status and low viral replication levels characterize chronic hepatitis B virus-infected women at reproductive age in Greece: A one-year prospective single center study显示文摘AIM: To evaluate the seroprevalence of hepatitis B surface antigen (HBsAg) in 13 581 women at reproductive age and the hepatitis B e antigen (HBeAg)/anti-HBe status as well as serum hepatitis B virus (HBV)-DNA levels in a subgroup of HBsAg(+) pregnant women at labor in Greece.METHODS: Serological markers were detected using enzyme immunoassays. Serum HBV-DNA was determined by a sensitive quantitative PCR assay. Statistical analysis of data was based on parametric methodology.RESULTS: Overall, 1.156% of women were HBsAg(+)and the majority of them (71.3%) were Albanian. The prevalence of HBsAg was 5.1% in Albanian women, 4.2%in Asian women and 1.14% in women from Eastem European countries. The prevalence of HBsAg in African (0.36%) and Greek women (0.29%) was very low. Only 4.45% of HBsAg (+) women were also HBeAg(+) whereas the vast majority of them were HBeAg(-)/anti-HBe(+). Undetectable levels of viremia (<200 copies/mL) were observed in 32.26% of pregnant women at labor and 29.03% exhibited extremely low levels of viral replication (<400 copies/mL). Only two pregnant women exhibited extremely high serum HBVDNA levels (>10 000 000 copies/mL), whereas 32.26%exhibited HBV-DNA levels between 1 500 and 40 000copies/mL.CONCLUSION: The overall prevalence of HBsAg is relatively low among women at reproductive age in Greece but is higher enough among specific populations. The HBeAg(-)/anti-HBe(+) serological status and the extremely low or even undetectable viral replicative status in the majority of HBsAg(+) women of our study population, suggest that only a small proportion of HBsAg(+) women in Greece exhibit a high risk for vertical transmission of the infection. | Ioannis S. Elefsiniotis Irene Glynou Ioanna Magaziotou Konstantinos D. Pantazis Nikolaos V. Fotos Hero Brokalaki Helen Kada George Saroglou | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 3 | Serological and virological profile of chronic HBV infected women at reproductive age in Greece显示文摘 | Ioannis S. Elefsiniotis Irene Glynou Hero Brokalaki Ioanna Magaziotou Konstantinos D. Pantazis Aikaterini Fotiou George Liosis Helen Kada George Saroglou | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 2 |
| 4 | Translation and validation of the Greek chronic liver disease questionnaire显示文摘AIM:To translate into Greek and validate the chronic liver disease questionnaire (CLDQ).METHODS:Two hundred and six consecutive adult patients with the diagnosis of a chronic liver disease from 2 general hospitals in Athens were enrolled in the study from May to September 2008.In order to assess their quality of life (QOL) the CLDQ was applied.The instrument was translated from English,back translated and reviewed in focus groups within the framework of a large multicenter study.The measurements that were performed included:2 independent sample t tests,oneway analysis of variance,reliability coefficients,explanatory factor analysis using a varimax rotation and the principal components method.RESULTS:One hundred and twenty five (61%) patients were men,half were aged 40-59 years and > 33% were > 60 years old.Among the patients,48 (23%) were hospitalized and 97 (47%) were cirrhotic according to the Child-Pugh score.The internal consistency of the Greek CLDQ version using Cronbach's alpha coefficient was found to be 0.93.Exploratory factor analysis identified 7 domains accounting for 65% of the variance of CLDQ items and only partially overlapping with those found in the original version.The area under the receiver operating characteristics curve was calculated at 0.813 and the logistic estimate for the threshold score of 167.50 provided a sensitivity of 74.3% and a specificity of 71.6% for the model.CONCLUSION:Our data confirmed the validity of the Greek version of the CLDQ in identifying the QOL among patients with chronic liver disease. | Zoi Kollia Evridiki Patelarou Victoria Vivilaki Eleni Kollia Florentia Kefou Ioannis Elefsiniotis Spyros P Dourakis Hero Brokalaki | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 5 | Importance of maternal and cord blood viremia in pregnant women with chronic hepatitis B virus infection显示文摘 | Elefsiniotis I S Tsoumakas K Papadakis M | 2011 | Eur J Intern Med2011，22，2： | 1 |
| 6 | The effect of temperature and carbon source on denitrification using volatile fatty acids 显示文摘 | Elefsiniotis P Li D | 2006 | Biochemical Engineering Journal2006，28，： | 1 |
| 7 | The effect of temperature and carbon source on denitrification using volatile fatty acids 显示文摘 | Elefsiniotis P Li D | 2006 | Biochem Eng J2006，28，2： | 1 |
| 8 | The effect of addition of potato-processing wastewater on the acidgenesis of primary sludge under varied hydraulic retention time and temperature显示文摘 | Banerjee A Elefsiniotis P Tuhtar D | 1999 | Biotechnology1999，72，： | 1 |
| 9 | Effects of motor boats on water quality in shallow lakes显示文摘 | Nedohin D N P Elefsiniotis | 1997 | Toxicological and Environmental Chemistry1997，61，1： | 1 |
| 10 | Clinical course of lamivudine monotherapy in patients with decompensated cirrhosis due to HBeAg negative chronic HBV infection 显示文摘 | Manolakopoulos S Karatapanis S Elefsiniotis J et a! | 2004 | Am J Gastroenterol2004，99，： | 1 |
| 11 | Serum anticardiolipin antibodies levels in patients with chronic hepatitis-B and its association with extra-hepatic manifestations显示文摘 | Elefsiniotis JS Papanikolaou IS Magaziotou /A et ai | 2001 | J Hepatol2001，34，1： | 1 |
| 12 | Influence of pH on the acid-phase anaerobic digestion of primary sludge显示文摘 | Elefsiniotis P Oldham W K | 1994 | Journal of Chemical Technology and Biotechnology1994，60，1： | 1 |
| 13 | Clinical significance of serum proealcitonin levels in patients with acute or chronic liver disease显示文摘 | Elefsiniotis IS Skounakis M Vezali E | 2006 | Eur J Gastroenterol Hepatol2006，18，5： | 1 |
| 14 | Spontaneous preterm birth in women with chronic hepatitis B virus infection 显示文摘 | Elefsiniotis I Tsoumakas K Vezali E | 2010 | Int J Gynaecol Obstet2010，3，10： | 1 |
| 15 | The effect of addition of potato-processing wastewater on the acidogenesis of primary sludge under varied hydraulic retention time and temperature 显示文摘 | Banerjee A Elefsiniotis P Tuhtar D | 1999 | J Biotechnol1999，72，3： | 1 |
| 16 | Use of sequencing batch reactors and Fenton's reagent to treat a wastewater from a textile industry显示文摘 | FONGSATITKUL P ELEFSINIOTIS P YAMASMIT A YAMASMIT N | 2004 | Biochemical Engineering Journal2004，21，3： | 1 |
| 17 | The role of HRT and low temperature on the acid-phase anaerobic digestion of munici pal and industrial wastewaters 显示文摘 | Maharaj I Elefsiniotis P | 2001 | Bioresour Technol2001，76，3： | 1 |
| 18 | Effect of HRT and temperature on the acidogenesis of municipal primary sludge and industrial wastewater显示文摘 | Banerjee A Elefsiniotis P Tuhtar D | 1998 | Water Science and Technology1998，38，89： | 1 |
| 19 | Unusual onset of varicel- la zoster reactivation with meningoencephalitis, followed by rhabdomy- olysis and renal failure in a young, immunocompetent patient 显示文摘 | Pirounaki M Liatsos G Elefsiniotis I | 2007 | Scand J Infect Dis2007，39，1： | 1 |
| 20 | Evaluation of feeder bus systems with probabilistic time-varying demands and non-additive time costs 显示文摘 | Chien S I Spasovic L N Elefsiniotis S S | 2001 | Transportation Research Record2001，1760，： | 1 |
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