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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | Trefoil factors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),which comprises ulcerative colitis and Crohn’s disease,is characterized by inflammation of the gastrointestinal tract.The trefoil factors 1,2,and 3(TFF1-3)are a family of peptides that play important roles in the protection and repair of epithelial surfaces,including the gastrointestinal tract.TFFs may be involved in IBD pathogenesis and are a potential treatment option.In the present review,we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression,possible function and pharmacological role in IBD. | Luise Aamann Else Marie Vestergaard Henning Grφnbk | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 3 | 加兰他敏治疗轻至中度阿尔茨海默病人的有效性及安全性:多中心随机对照试验显示文摘 | Gordon K Wilcock Sean Lilienfeld Els Gaens 殷剑 | 2001 | 英国医学杂志中文版2001，4，4： | 5 |
| 4 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 5 | Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs显示文摘 | Els Conrath K Lauwereys M Wyns L | 2001 | J Biol Chem2001，276，10： | 1 |
| 6 | Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease:multicentre randomised controlled trail显示文摘 | GORDON K W SEAN L ELS G | 2000 | BMJ2000，321，： | 1 |
| 7 | Health related quality of life in coronary patients and its association with their cardiovascular risk profile: Results from the EUROASPIRE III survey显示文摘 | Delphine De Smedt Els Clays Lieven Annemans Frank Doyle Kornelia Kotseva Andrzej Paj?k Christof Prugger Catriona Jennings David Wood Dirk De Bacquer | 2012 | International Journal of Cardiology2012，，： | 1 |
| 8 | Strategic management of complex projects:a case study using system dynamics显示文摘 | LYNEIS J M COOPER K G ELS S A | | 0，，03： | 1 |
| 9 | Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs显示文摘 | Els Conrath K Lauwereys M Wyns L | 2001 | J Biol Chem2001，276，10： | 1 |
| 10 | Toward Understand- ing the Essence of Post-Translational Modifications for the My- cobacterium tuberculosis Immunoproteome 显示文摘 | van Els CA Corbiere V Smits K | 2014 | Front Immu- nol2014，5，： | 1 |
| 11 | Rapid onset of apoptosis in vitro follows disruption of beta 1 integrin/matrix interactions in human colonic crypt cells显示文摘 | Strater J Wedding U Barth TF Koretz K Elsing C Moller P | 1996 | Gastroenterology1996，100，6： | 1 |
| 12 | Intestinal nematode parasites,cytokines and effector mechanisms显示文摘 | Else K J Finkelman FD | | 0，，08： | 1 |
| 13 | Characterization of a cDNA encoding the Bovine coxsackie and adenovirus receptor 显示文摘 | Inge T Els K Michael L | 2001 | Bio & Bio Res Com2001，288，4： | 1 |
| 14 | Strategic management of complex projects:A case study using system dynamics显示文摘 | Lyneis J M Cooper K G Els S A | 2001 | System Dynamics Review2001，17，3： | 1 |
| 15 | miR-18, a member of Oncomir-1, targets heat shock transcrip- tion factor 2 in spermatogenesis 显示文摘 | Bj ork J K Sandqvist A Elsing A N | 2010 | Development2010，137，19： | 1 |
| 16 | Breast cancer resistance protein (Bcrpl/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin Bl, IQ and Trp-P-1 but also mediates their secretion into breast milk 显示文摘 | HERWAARDEN A E ELS W BARBARA K | 2006 | Carcinogenesis2006，27，： | 1 |
| 17 | A Reformulation of the Theory of Optimal Congestion Taxes 显示文摘 | ELSE P K | 1982 | Journal of Transport Economics and Policy1982，15，3： | 1 |
| 18 | X-ray structure determination, absolute configuration and biological activity of phomoxanthone A显示文摘 | Els asser B Krohn K Flo rke U | 2005 | European Journal of Organic Chemistry2005，2005，21： | 1 |
| 19 | System level hardware/software partitioning based on simulated annealing and tabu search 显示文摘 | Else P Peng Z Kueheinski K | 1997 | Design Automation of Embedded Systems1997，2，1： | 1 |
| 20 | Have gastrointestinal nematodes outwitted the immune system? 显示文摘 | ELSE K J | 2005 | Parasite Immunology2005，27，1011： | 1 |
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