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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	The plane problem of an elliptically reinforced circular hole in an ani~tropic plate or lanainate 显示文摘	Engels H Zakharov D Bccker W	2001	Archive of Applied Mechanics2001，71，9：	1
3	The Radiation Sensitivities of Three Species of Fiddler Crabs显示文摘	Engel D W		0，，：	1
4	The plane problem of an elliptically reinforced circular hole in an anisotropic plate or laminate显示文摘	ENGELS H ZAKHAROV D BECKER W	2001	Archive of Applied Mechanics2001，71，9：	1
5	Accumulation and eytosolic partitioning of metals in 1he American oysler Crassostrea virginica显示文摘	Engel D W	1999	Marine Environ mental Research1999，47，1：	1
6	Radio-frequency identification:Secure risks and challenges显示文摘	S E Sarma S A Weis D W Engels	2003	RSA Laboratories Cryptobytes2003，6，1：	1
7	Effects of moulting and environmental factors on trace metal body-burdens and haemocyanin concentrations in the American lobster,Homarus americanus显示文摘	Engel D W Brouwer M Mercaldo-Allen R	2001	Marine Environmental Research2001，52，：	1
8	Metal regulation and molting in the blue crab, Callinectes sapidus: Metallothionein function in metal metabolism 显示文摘	ENGEL D W BROUWER M	1987	Biological Bulletin1987，173，：	1
9	Effects of molting and environmental factors on trace metal body-burdens and hemocyanin concentrations in the American lobster, Homarus americanus 显示文摘	Engel D W Brouwer M Allen M	2001	Mar Environ Res2001，52，：	1
10	Radio Frenquency Identification : Secrue Risksand Challenges 显示文摘	Sarma S E Engels D W	2003	RSA Laboratories Crypto bytes2003，6，1：	1
11	The plane problem of an elliptically reinforced circular hole in an anisotropic plate or laminat显示文摘	Engels H Zakharov D Becker W	2001	Archive of Applied Mechanics2001，71，9：	1
12	Radio frequency identifi- cation: secure risks and challenges 显示文摘	SARMA S E WEISS A ENGELS D W	2003	RSA Laboratories Crypto- bytes2003，6，1：	1
13	Radio-frequency-identification secure risks and challenges 显示文摘	Sarma S E Weis S A Engels D W	2003	Cryptophytes2003，6，1：	1
14	Radio frequency identification:Secure risks and challenges显示文摘	Sarma S E Weis S A Engels D W	2003	RSA Laboratories Crypto bytes2003，6，1：	1
15	Techniques for scheduling with rejection 显示文摘	Engels D W Karger D R Kolliopoulos S G	2003	Journal of Algorithms2003，49，1：	1
16	Techniques for scheduling with rejection 显示文摘	Engels D W Karger D R Kolliopoulos S G	2003	Journal of Algorithms2003，49，：	1
17	Reaction of single- walled carbon nanotubes with organic peroxides 显示文摘	Engel P Billups W Abmayr D	2008	The Joumal of Physical Chemistry C2008，112，3：	1
18	Radio frequency identifica- tion: Secure risks and challenges 显示文摘	SARMA S E WEI S A ENGELS D W	2003	RSA Laboratories Crypto bytes2003，6，1：	1
19	Risk analysis for a reliable and safe surgical mbat system显示文摘	Korb W Engel D Boesecke R	2003	International Congress Series2003，1256，：	1
20	Radio-frequency identification:Secure risks and challenges显示文摘	Sarma S E Weis S A Engels D W	2003	RSA Laboratories Cryptobytes2003，6，1：	1

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