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| 1 | 青光眼患者血清抗视网膜抗原的抗体轮廓质谱分析显示文摘目的比较原发性开角型青光眼(POAG)患者与正常对照(CTRL)者间的抗体轮廓差异。方法病例对照研究。将44例POAG患者与48例CTRL者的血清分别加入到含有预洗Dyna珠-G蛋白的反应管中,以捕获人免疫球蛋白G(IgG)抗体,形成的IgG—G蛋白复合体用来捕获目标抗原(匀质化牛视网膜组织)。经洗提后获得的抗原蛋白通过“表面增强激光解吸附-电离-飞行时间-质谱”仪进行检测。采用Proteomic software project统计学软件,对两组质谱数据连同受检者年龄和性别等参数,自动进行t检验和初步多变量判别分析;随后采用Statistica version8.0统计学软件,进行包括抗原蛋白质谱数据、蛋白质芯片类型和激光解吸附-电离能量等的多变量判别分析。结果CTRL组的平均质谱强度为4244.427±4721.115,POAG组为4049.864±4083.819,两组间差异有统计学意义(F=1.340,P〈0.01);在POAG患者中,出现了部分高调节免疫反应,但主要表现为低调节免疫反应。结论在POAG患者与CTRL者之间存在明显的抗体轮廓差异,在POAG组中出现的低调节免疫反应表明部分患者可能与“异常免疫”有关。 | 严良 Joachim S. C Pfeiffer N Grus F.H Erb C | 2009 | 中华眼科杂志2009，45，7： | 3 |
| 2 | Ecological footprint time series of Austria, the Philippines, and South Korea for 1961 - 1999: Comparing the conventional approach to an 'actual land area' approach 显示文摘 | WACKERNAGEL M MONFREDA C ERB KARL- HEINZ HABERL H SCHULZ N B | 2004 | Land Use Policy2004，，21： | 1 |
| 3 | Thermal gradient gel electrophoresis analysis of bioprotection from pollutant shocks in the activated sludge microbi al community显示文摘 | Eichner C A Erb R W Timmis K N | 1999 | Applied and Environmental Micro biology1999，65，： | 1 |
| 4 | Thermal gradient gel electrophoresis analysis of bioprotection from pollutant shocks in the activated sludge microbial community显示文摘 | Eichner C A Erb R W Timmis K N | 1999 | Applied Microbial Biotechnology1999，65，： | 1 |
| 5 | Bioprotection of microbial communities from toxic phenol mixtures by a genetically designed pseudomonad 显示文摘 | Erb R W Eichner C A Timmis K N | 1997 | Nature Biotechnology1997，15，4： | 1 |
| 6 | Relationship of changes in condition score to cow health in Holsteins显示文摘 | Gearhart M A Curtis C R Erb H N | 1990 | Journal of Dairy Science1990，73，： | 1 |
| 7 | Thermal gradi-ent gel electrophoresis analysis of bioprotection from pollu-tant shocks in the activated sludge microbial community显示文摘 | Eichner C A Erb R W Timmis K N^ | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 8 | Tackling ischaemic heart disease in rheumatoid arthritis 显示文摘 | KITAS GD ERB N | 2003 | Rheumatology (Oxford)2003，42，5： | 1 |
| 9 | Relationship of changes in condition score to cow health in Holsteins显示文摘 | Gearhart M A Curtis C R Erb H N | 1990 | J Dairy Sci1990，73，11： | 1 |
| 10 | A comparison of platelet parameters in EDTA- and citrate-anticoagulated blood in dogs显示文摘 | Stokol T Erb H N | 2007 | Veterinary Clinical Patholo- gy2007，36，2： | 1 |
| 11 | An ecological analysis of factors for postpartumdiaorders of Holstein-Friesian cows from thirty-two New York farms显示文摘 | Correa M T Curtis C R Erb H N | 1990 | Dairy Sci1990，73，： | 1 |
| 12 | Linking pattern and process in cultural landscape: An empirical study based on spatially explicit indicators显示文摘 | Wrbka T Erb K H Schulz N B | 2004 | Land Use Policy2004，21，： | 1 |
| 13 | Thermal gradient gel electrophoresis analysis of bioprotection from pollutant shocks in the activated sludge microbial community显示文摘 | EICHNER C A ERB R W TIMMIS K N | 1999 | Applied and Environmental Microbiology1999，65，1： | 1 |
| 14 | Association of parturient hypocalcaemia with eight periparturient disorders in Holstein cows显示文摘 | Curtis C R Erb H N Sniffen C J | 1983 | J AM VET MED ASSOC1983，183，： | 1 |
| 15 | Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells显示文摘 | Yu N Erb L Shivaji R | 2008 | Circ Res2008，102，5： | 1 |
| 16 | Linking pattem and process in cultural landscape: An empirical study based on spatially explicit indicators 显示文摘 | WRBKA T ERB K H SCHULZ N B | 2004 | Land Use Policy2004，21，3： | 1 |
| 17 | Linking pattern and process in cultural landscapes:an empirical study based on spatially explicit indicators显示文摘 | Wrbka T Erb K H Schulz N B | 2004 | Land Use Policy2004，21，3： | 1 |
| 18 | Appl Environ Microbial 显示文摘 | Eicher C A Erb R W Timmis K N | 1996 | 62(10): 3787-37931996，62，10： | 1 |
| 19 | Thermal gradientgel electrophoresis analysis of bioproection from pollutant shocksin the activated sludge microbial community 显示文摘 | Eichner C A Erb R W Timmis K N | 1999 | Appl EnvironMicrobiol1999，65，： | 1 |
| 20 | Urinary estrogen excretion rates during pregnancy in the bovine显示文摘 | ERB R E RANDEL R D MELLIN T N | 1968 | Journal of Dairy Science1968，51，3： | 1 |
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