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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression显示文摘 | HELMRATH M A SHIN C E ERWIN C R | 1998 | Journal of Pediatric Surgery1998，33，7： | 1 |
| 4 | A three degrees-of-freedom adaptive-passive isola- tor for launch vehicle payloads显示文摘 | KHORRAMI F RASTEGAR J R ERWIN R S | 2000 | SPIE2000，3991，： | 1 |
| 5 | Industrial Relations Climate,Attendance Behavior and the Role of Trade Unions显示文摘 | Deery S Erwin P Iverson R | | 0，，04： | 1 |
| 6 | Candida albicans drug resistance-another way to cope with stress显示文摘 | Richard D C Erwin L Ann R H | 2007 | Microbiology2007，153，10： | 1 |
| 7 | Influence of Mastitis on Properties of Milk X-Fatty Acid Composition显示文摘 | RANDOLPH H E ERWIN R E | 1974 | J Dairy Sci1974，57，： | 1 |
| 8 | Evaluation of diaphrag- matic injuries显示文摘 | Arohoff R J Jack R Erwin RT | 1982 | AM J Surg1982，144，6： | 1 |
| 9 | Epidermal growth factor is critical for intestinal adaptation following small bowel resection 显示文摘 | Stem L E Erwin C R O'Brien D P | 2000 | Microsc Res Tech2000，51，2： | 1 |
| 10 | Autecol- ogy and the filling of ecospace: key metazoan radia- tions 显示文摘 | BAMBACH R K BUSH A M ERWIN D H | 2007 | Palaeontology2007，50，： | 1 |
| 11 | The Economic Theory of Index Numbers and the Measurement of Input, Output, and Productivity 显示文摘 | DOUGLAS W CAVES LAURITS R CHRISTENSEN W ERWIN DIEWERT | 1982 | Econometirca1982，50，6： | 1 |
| 12 | Applications of life cycle assessment to nature worksTM polylactide (PLA) production显示文摘 | Erwin T H Vink Karl R Rábago David A Glassner | 2003 | Polymer Degradation and Stability2003，80，： | 1 |
| 13 | Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis显示文摘 | Erwin B Felix R Jorg H | 2007 | European Journal Gastroenterol & Hepatol2007，19，10： | 1 |
| 14 | Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos 显示文摘 | Carney MW Erwin K Hardman R | 2008 | Mar Pollut Bull2008，57，612： | 1 |
| 15 | A Three Degree-of-Freedom Adaptive-Passive Isolator for Launch Vehicle Payloads 显示文摘 | Khorrami F Rastegar J Erwin R S | 2000 | Proceedings of SPIE2000，3991，： | 1 |
| 16 | Nucleotide sequence of the bovine growth hormone chromosomal gene 显示文摘 | Gordon D F Quick D P Erwin C R | 1983 | Moleculer and Cellular Endocrinology1983，333，： | 1 |
| 17 | Surface elevation dynamics in vegetated Spartina marshes versus unvegetated tidal ponds along the Mid-Atlantic coast,USA,with implications to waterbirds显示文摘 | ERWIN R M CAHOON D R PROSSER D J | 2006 | Estuaries and Coasts2006，29，1： | 1 |
| 18 | An investigation of lead-time effects in manufacturing/remanufacturing systems under simple PUSH and PULL control stralegies 显示文摘 | Erwin van der Laan Salomon M Dekker R | 1999 | European Journal of Operational Research1999，115，1： | 1 |
| 19 | Cefquinome (HR 111 V) in vitro evaluation of a broad-spectrum cephalosporin indicated for infections in animals 显示文摘 | Murphy S P Erwin M E Jones R N | 1994 | Diagn Microbiol Infect Dis1994，20，1： | 1 |
| 20 | Temperature effects on lilium development rate and morphology from the visible bud stage until anthesis显示文摘 | Erwin J E Heins R D | 1990 | American Society of Horticultural Science1990，11，4： | 1 |
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