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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Statistical analysis of real - timePCR data显示文摘 | Yuan J S Reed A Chen F | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 4 | Statistical analysis of re- al-time PCR data 显示文摘 | Yuan JS Reed A Chen F | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 5 | Effect of doping on the magnetic properties of GaMnN: Fermi level engineering显示文摘 | Reed M J Arkun F E Berkman E A | 2005 | Applied Physics Letters2005，86，10： | 1 |
| 6 | Enhanced in vitro growth of murine fibroblast cells and preimplantation embryos cultured in medium supplemented with an amphipathic peptide显示文摘 | Reed W A White K L Enright F M | 1992 | Mol Reproduct1992，31，2： | 1 |
| 7 | Phosphomannose isomerase:an efficient selectable marker for plant transformation显示文摘 | Reed J Privallel L Powell M L Meghji M Dawson J Dunder E Suttie J Wenck A Launis K Kramer C Chang Y F Hansen G Wright M | | 0，，： | 1 |
| 8 | Interleukin 2 promoter/enhance controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus 显示文摘 | Elzer P H Enright F M | 1997 | Transgenic Research1997，6，5： | 1 |
| 9 | Effect of Doping on the Magnetic Properties of GaMnN: Fermi Level Engineering 显示文摘 | Reed M J Arkun F E Berkman E A | 2005 | Appl Phys Lett2005，86，10： | 1 |
| 10 | Statistical analysis of real-time PCR data 显示文摘 | Yuan JS Reed A Chen F et at | 2006 | BMC Bioiuformatics2006，22，7： | 1 |
| 11 | Dependence of ferromagnetic properties on carrier transfer at GaMnN/GaN : Mg interface 显示文摘 | ARKUN F E REED M J BERKMAN E A | 2004 | APL2004，85，17： | 1 |
| 12 | Silicon-on-insulator optical rib waveguide loss and mode characteristics显示文摘 | Rickman A G Reed G T Namavar F | 1994 | Journal of Lightwave Technology1994，12，10： | 1 |
| 13 | Intermolecular interactions from a natural bond orbital donor-acceptor view point显示文摘 | Reed A E Curtiss. L. A Weinhold F | | 0，，： | 1 |
| 14 | Intermolecular interactions froma natural bond orbital,donor-acceptor viewpoint显示文摘 | REED A E CURTISS L A WEINHOLD F | 1988 | Chem Rev1988，88，6： | 1 |
| 15 | 查看详情显示文摘 | Reed W A Yan M F Schnitzer M J | | 0，，： | 1 |
| 16 | Dry eye signs and symptoms in women with premature ovarian failure 显示文摘 | Smith J A Vitale S Reed G F | 2004 | Arch Ophthalmol2004，122，： | 1 |
| 17 | Natural popula- tion analysis显示文摘 | Reed A E Weinstock R B Weinhold F | 1985 | Chem Phys1985，83，2： | 1 |
| 18 | Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis 显示文摘 | Yu F Thamm A M Reed D | 2013 | Phytochemistry2013，91，： | 1 |
| 19 | Natural bond orbital analysis of molecular interactions: Theoreticalstudies of binary complexes of HF, H2 O, NH3 , N2 , O2 , F2, CO,and CO2 with HF,H2O,and NH3 显示文摘 | Reed A E Weinhold F Curtiss L A | 1986 | Chem Phys1986，84，： | 1 |
| 20 | Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis显示文摘 | Spafford M F Koch W M Reed A L | 2001 | Clin Cancer Res2001，7，3： | 1 |
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