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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Retinitis pigmentosa:rod photoreceptor rescue by a calcium-channel blocker in the rd mouse显示文摘 | Frasson M Sahel J A Fabre M | 1999 | Nat Med1999，5，10： | 1 |
| 4 | The muscle pattern of the Drosophila abdomen depends on a subdivision of the anterior compartment of each segment显示文摘 | Krzemien J Fabre CC Casal J | | 0，，： | 1 |
| 5 | Randomized con- trolled trial of early comparexl with delayed use of inhaled nitric oxide in newborns with a moderate respiratory failure and pul- monary hypertension显示文摘 | Gonzalcz A Fabres J D' Aprcmont I | 2010 | J Perinatol2010，30，6： | 1 |
| 6 | Modulation of the expression of the VIP receptor by serum factors on the human melanoma cell line IGR39 显示文摘 | Fabre C Secchi J | 1992 | Exp Cell Res1992，200，1： | 1 |
| 7 | Value of CT in the diagnosis and management of patients with suspected acute small bowel obstruction显示文摘 | Taourel P G Fabre Jm Pradel J A | 1995 | AJR1995，165，5： | 1 |
| 8 | Antitumor active beta - D -glucans from phytophthora parasitica显示文摘 | Fabre I Perret J Michel G | 1988 | Carbohydr Res1988，175，1： | 1 |
| 9 | Residual stress measurements using neuron diffraction in magnesium alloy laser welded joints显示文摘 | Barrallier L Fabre A Masse J E | 2002 | Material Science Forum2002，，： | 1 |
| 10 | 2-Phenylethyl alcohol: an aroma profile显示文摘 | FABRE C E BLANC P J GOMA G | 1998 | Perfumer & Flavorist1998，23，3： | 1 |
| 11 | Sizing of bubbles by incoherent imaging: defocus bias显示文摘 | Bongiovanni C Chevaillier J Fabre J | 1997 | Experiments in fluids1997，23，： | 1 |
| 12 | Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep 显示文摘 | Demars J Fabre S Sarry J | 2013 | PLoS Genetics2013，9，10： | 1 |
| 13 | Ethics and scientific publication显示文摘 | Benos D J Fabres J Farmer J | 2005 | Advan Physiol Educ2005，29，： | 1 |
| 14 | Randomized controlled trial of early compared with delayed use of inhaled nitric oxide in newborns with a moderate respiratory failure and pulmonary heper- tension显示文摘 | Gonz61ez A Fabres J D'Apremont I | 2010 | J Perinato2010，30，6： | 1 |
| 15 | Encapsulation-dehydration: a new approach to cryopreservation of Solanum shoot-tips显示文摘 | Fabre J Dereuddre J | 1990 | Cryo-letters1990，11，6： | 1 |
| 16 | Effect of pO2 on antitumor drug cytotoxieity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line显示文摘 | Lelong-Rebel I Brisson C Fabre M Bergerat J P Rebel G | 2008 | Anticancer Res2008，28，1： | 1 |
| 17 | Extraction of 2-phenylethyl alcohol by techniques such as adsorption, inelu sion, supereritieal CO2, liquid-liquid and membrane separa tions显示文摘 | FABRE C E BLANC P J MARTY A | 1996 | Perfumer & Flavorist1996，21，54： | 1 |
| 18 | Intravenous immunoglobulin delays xenogenic hyperacute rejection in a model of pig liver perfusion with human blood显示文摘 | GAUTREAU C FABRE GM KULICS J | 1996 | Transplant Prec1996，28，2： | 1 |
| 19 | CRISPR typing and sub- typing for improved laboratory surveillance of Salmonella infec- tions显示文摘 | Fabre L Zhang J Guigon G | 2012 | PloS One2012，7，36： | 1 |
| 20 | Severity scores in children with acute pancreatitis 显示文摘 | FABRE A PETIT P GAUDART J | 2012 | J Pediatr Gastroenterol Nutr2012，55，3： | 1 |
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