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| 1 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 2 | Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis显示文摘Background: Risk strati cation and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Methods: Totally 121 na ve patients with HCC were included. HCC radiological evaluation and staging were done. LSM was measured using virtual touch quanti cation. Patients were divided into early to intermediate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estimated. Results: The mean LSM inside the tumor was signi cantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (P<0.001). In late HCCs stage, the mean LSM inside the tumor and in the peri-tumoral tissue was lower than the corresponding values in the early to intermediate HCCs stage (P<0.001). LSM inside the tumor and in the peri-tumoral tissue negatively correlated with serum AFP, tumor vascular invasion, and stage (P<0.05). The recurrence-free interval was directly correlated to LSM inside the tumor and inversely to LSM in cirrhotic non tumorous liver part. Kaplan-Meier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSM inside the tumor of ≥1.25m/s compared to those with LSM inside the tumor of<1.25m/s. Conclusions: LSM can serve as a potential non-invasive predictor for HCC clinical behavior and the recurrence-free interval following loco-regional treatments. | Sameh A Lashen Mohamed M Elshafei Fahmy H Hablass Eman A Alsayed Asmaa A Hassan | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 3 | Development of an effective process for utilization of collagen from livestock and fish waste显示文摘 | S Morimura H Nagata Y Uemura A Fahmi T Shigematsu K Kida | 2002 | Process Biochemistry2002，，12： | 2 |
| 4 | Role of TL1A in the pathogeneais of rheumatoid arthritis 显示文摘 | Zhang J Wang X Fahmi H | 2009 | J Immunol2009，183，8： | 1 |
| 5 | Analysis of Composite Beams withRectangular Web Openings 显示文摘 | FAHMY E H | 1996 | Journal of Construc-tional Steel Research1996，37，1： | 1 |
| 6 | Integrated evaluation of Egypt' s water resources plans -A framework to cope with sustainability 显示文摘 | Nardiai A Fahmy H | 2005 | Water Inter2005，30，3： | 1 |
| 7 | Production of angiotensin I converting enzyme inhibitory peptides from sea bream scales 显示文摘 | Fahmi A Morimura S Guo H C | 2004 | Process Biochemistry2004，39，： | 1 |
| 8 | Role of TL1A in the pathogencsis of rheumatoid arthritis显示文摘 | Zhang J Wang X Fahmi H et at | 2009 | J Immunol2009，183，8： | 1 |
| 9 | Role of TL1A in the pathogenesis of rheumatoid arthritis显示文摘 | Zhang J Wang X Fahmi H | 2009 | J Immunol2009，183，8： | 1 |
| 10 | Improving RC- PSP solutions quality with stacking justification - application with particle swarm optimization显示文摘 | FAHMY A HASSAN T M BASSIONI H | 2014 | Expert Systems with Applications2014，41，13： | 1 |
| 11 | Reliability evaluation in distributed computing environments using the AHP 显示文摘 | Mahmoud H Fahmy A | 2001 | Computer Networks2001，36，56： | 1 |
| 12 | Protective effect of apelin,amlodipine and anakinra in ischemia-reperfusion injury in myocardium显示文摘 | Edrees HM Fahmy EK Mostafa H | 2014 | Inter J Med2014，3，1： | 1 |
| 13 | Quality by design, part II: Application of NIR spectroscopy to monitor the coating process for a pharmaceutical sustained release product显示文摘 | Tabasi S H Fahmy R Bensley D | 2008 | J Pharm Sci2008，97，9： | 1 |
| 14 | 查看详情显示文摘 | El-masry A H Fahmy H H Abdelwahed S H A | | 0，，： | 1 |
| 15 | Enhancement of famotidine dissolu- tion rate through liquisolid tablets formulation:in vitro and In vivo evaluation显示文摘 | Fahmy R H Kassem M A | 2008 | Eur J Phartn Biopharm2008，69，： | 1 |
| 16 | Validation of finite element models of liver tissue using Micoro-CT 显示文摘 | SHI H J FARAG A A FAHMI R | 2008 | IEEE Transactions On Biomedical Engineering2008，55，3： | 1 |
| 17 | Production of angiotensin I converting enzyme inhibitory peptides from sea bream scales 显示文摘 | Fahmi A Morimur S Guo H C Shigematsu T Kida K Uemura Y | 2004 | Process Biochemistry2004，39，10： | 1 |
| 18 | Brazing of Si3N4 ceramic to copper显示文摘 | Elsawy A H Fahmy M F | 1998 | Journal of Materials Processing Technology1998，77，： | 1 |
| 19 | Effects of pulp fibre on soil physical properties and soil erosion under simulated rainfall 显示文摘 | Chow T L Rees H W Fahmy S H | 2003 | Canadian Journal of Soil Science2003，83，： | 1 |
| 20 | Bioscouring of linen fabric in comparison with conventional chemical treatment 显示文摘 | ABDEL-HALIM E S FAHMY H M MOUSTAFA M G Fouda | 2008 | Carbohydrate Polymers2008，74，3： | 1 |
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