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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Modeling material failure in concrete structures under cyelie aetions显示文摘 | Faria R Oliver J Cervera M | 2004 | Journal of Structural Engineering2004，130，12： | 1 |
| 3 | Adsorp tion of anionic and Cationic dyes on activated carbons with different surface chemistries显示文摘 | Faria P C C (O)rafo J J M PereiraM F R | 2004 | Water Res2004，38，： | 1 |
| 4 | The effect of piezoelectrically induced stress stiffening on the aeroelastic stability of curved composite panels显示文摘 | Almeida A Donadon M V Faria A R | 2012 | Composite Structures2012，94，12： | 1 |
| 5 | Mycoinsecticides and mycoacaricides: a comprehensive list with worldwide coverage and international classification of formulation types 显示文摘 | Faria M R Wraight S P | 2007 | Biological Control2007，43，： | 1 |
| 6 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 7 | Purification and N- terminal Amino Acid Sequence of Enterocin CRL 35, a ' Pediocin -like' Bacteriocin Produced by Enterococcus faecium CRL35显示文摘 | Farias M E Farias R N de Ruiz H A | 1996 | Lett Appl Microbiol1996，22，6： | 1 |
| 8 | Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis显示文摘 | Pakneshan P Szyf M Farias Eisner R | 2004 | J Biog Ckem2004，279，31： | 1 |
| 9 | Commercial quality of pot chrysanthemum,cultivar Puritan,irrigated at different substrate water tension in a greenhouse显示文摘 | De Farias M F Saad J C C Boas R L V | 2003 | Irrigation2003，8，2： | 1 |
| 10 | Numerical modeling of concrete curing, regarding hydration and temperature phenomena显示文摘 | Cervera M Faria R Oliver R | 2002 | Computer & Structure2002，80，： | 1 |
| 11 | Effect of gallic acid and catechin on lactobacillus hilgardii 5w growth and metabolism of organic compounds显示文摘 | ALBERTO M R FARIAS M E MANCA M C | 2001 | Journal of Agriculture and Food Chemistry2001，49，9： | 1 |
| 12 | Adsorption of anionic and cationic dyes on activated carbon with different surface chemistries显示文摘 | Faria P C 6 rfno J JM Pereira M F R | 2004 | Water Reasearch2004，38，8： | 1 |
| 13 | Irrigation schedule in pot chrysanthemum,cultivar Rage,grown in greenhouse显示文摘 | De Farias M F Saad J C C Boas R L V | 2004 | Engenharia-Agricola2004，24，1： | 1 |
| 14 | The ER luminal binding protein (BiP) mediates an increase in drought tolerance in soybean and delays drought-induced leaf senescence in soybean and tobacco显示文摘 | Valente M A S Faria J A Q A Soares-Ramos J R L | 2009 | Journal of Experimental Botany2009，60，2： | 1 |
| 15 | Adsorptive striooing voltammetric behavior of UO2(II) complexed with the Schiff base N, N-prime-ethylenebis in 4-( 2-hydrox- ygthyl)-1-piperazine ethanesulfonic acid medium显示文摘 | Bastod M B R Moreira J C Farias P A M | 2000 | Anal Chim Acta2000，408，1： | 1 |
| 16 | Improving the corrosion resistance of NdFeB magnets:an electrochemical and surface analytical study显示文摘 | Saliba-Silva A Faria R N Baker M A | 2004 | Surface and Coatings Technology2004，185，： | 1 |
| 17 | Characterization of zirconized silica supports for HPLC显示文摘 | Faria A M Magalhaes D R Collins K E | 2005 | Analytica Chimica Acta2005，550，1： | 1 |
| 18 | Improving the corrosion resistance of NdFeB magnets an electrochemical and surface analytical study显示文摘 | SALIBA-SILVA A FARIA R N BAKER M A | 2004 | Surface and Coatings Technology2004，185，： | 1 |
| 19 | Enantiodivergent syntheses of cycloheptenone intermediates for guaiane sesquiterpenes 显示文摘 | FARIA M L MAGALHAES R A SILVA F C | 2000 | Tetrahedron : Asymmetry2000，11，20： | 1 |
| 20 | 显示文摘 | Farias W R L Valente A P Pereira M S | 2000 | Journal of Biological Chemistry2000，275，： | 1 |
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