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| 1 | “裸足”运动方式对下肢生物力学功能调整的研究进展显示文摘足部作为人体动力链与外界环境接触的始端,形态的变化与功能的表现紧密相关。通过对即刻与短期裸足运动干预以及长期裸足运动人群的足部形态和运动学、动力学、肌肉活动度等生物力学特征进行系统总结归纳,旨在从生物力学角度揭示裸足运动的本质特征,探究形态与功能的关联。研究发现,习惯着鞋人群在短期裸足步行及跑步运动干预时,均表现出小步长、高步频的时空参数特征。短期裸足步行及跑步后足触地角度减小,踝关节跖屈增大,膝关节屈曲程度增大等运动学特征与习惯裸足人群的运动学特征相似。对习惯着鞋人群进行短期裸足步行及跑步干预时,比习惯裸足人群在着地期的冲击峰值及垂直负荷增长率均呈现降低。长期使用不合脚鞋具可改变足形和功能,如足部肌群横截面积减小,足前掌宽度及接触面积降低,拇指外翻及削弱绞盘功能等。被抑制的足部功能或许是习惯着鞋人群损伤风险较大的原因,而开展裸足运动时需综合考量足形态与功能,循序渐进,以实现足部功能训练,提高运动表现。 | 顾耀东 孙冬 Gusztáv Fekete 梅齐昌 李建设 | 2019 | 中国体育科技2019，55，1： | 19 |
| 2 | 鞋钉构造对专业足球运动员在不同草坪条件下的生物力学表现分析显示文摘研究目的:探讨不同草坪下不同鞋钉构造对足球运动员进行特征动作的下肢生物力学表现和非接触性运动损伤风险。研究方法:选取14名专业男性足球运动员作为受试者,受试者分别着长钉足球鞋(Soft Ground Design,SG)、短钉足球鞋(Artificial Ground Design,AG)和碎钉足球鞋(Turf Cleats,TF)在自然草皮(Natural Turf,NT)和人工草皮(Artificial Turf,AT)条件下进行直线加速跑和45°左侧切动作。Vicon三维红外运动分析系统用于采集下肢运动学数据、Kistler三维测力台同步收集地面反作用力数据。研究结果:直线加速跑和45°侧切动作中,AT-SG的膝关节峰值屈曲角度和屈曲活动度均显著大于NT-TF和AT-TF;NT-SG和AT-SG的地面反作用力垂直负荷加载率(VALR)显著高于NT-TF和AT-TF,鞋钉和草皮交互作用显著。45°侧切动作中,AT-SG和NT-TF的平均抓地系数值最小,鞋钉和草皮交互作用显著。研究结论:长钉SG足球鞋在AT较大的膝关节屈曲角度和屈曲活动度有利于缓冲较大的地面冲击力,但容易引起长时间运动疲劳程度加快,导致非接触性运动损伤风险的增加。同时,长钉SG足球鞋在AT上较高的VALR容易引起如胫骨疲劳性骨折、跟腱炎等损伤风险的增加。 | 孙冬 Gusztáv Fekete 顾耀东 李建设 | 2018 | 中国体育科技2018，54，1： | 8 |
| 3 | 高跟鞋致损伤的生物力学与流行病学研究进展显示文摘以降低高跟鞋损伤风险为出发点,对高跟鞋步态生物力学特征进行系统综述,并结合相关流行病学依据对高跟鞋引发的肌肉骨骼系统损伤情况作出总结,为进一步研究提供思路.对高跟鞋步态中足底压力分布、下肢各关节三维角度变化及关节力矩特征三方面进行了较为全面的总结与分析,并且明确阐述了高跟鞋对踝关节扭伤、足部疼痛及摔倒的生物力学机制的影响.但到目前为止,没有足够的流行病学研究证据可以证明高跟鞋会增加膝关节炎的患病风险.随着对高跟鞋步态及其损伤机制更为明确与深入的认识,高跟鞋设计也将朝着更加人性化与合理化的方向发展. | 张妍 顾耀东 Gusztáv Fekete | 2017 | 宁波大学学报(理工版)2017，30，3： | 6 |
| 4 | Hot deformation of Mg-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction显示文摘The compressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy containing a low amount of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction technique.Tests were conducted at temperatures between room temperature and 350℃.Detailed microstructure investigation was provided by scanning electron microscopy,particularly the backscattered electron imaging and electron backscatter diffraction technique.The results show that twinning lost its dominance and kinking of the LPSO phase became more pronounced with increasing deformation temperature.No cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deformation of the alloy was mainly realized by the dynamic recrystallization of the Mg matrix. | Klaudia Horváth Fekete Daria Drozdenko Jan Capek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 5 | Prevalence and correlates of aggressive behavior in psychiatric inpatient populations显示文摘Aggressive behavior in patients with psychiatric disorders is attracting increasing research interest.One reason for this is that psychiatric patients are generally considered more likely to be aggressive,which raises a related question of whether diagnoses of psychiatric disorders predict the prevalence of aggressive behavior.Predicting aggression in psychiatric wards is crucial,because aggressive behavior not only endangers the safety of both patients and staff,but it also extends the hospitalization times.Predictions of aggressive behavior also need careful attention to ensure effective treatment planning.This literature review explores the relationship between aggressive behavior and psychiatric disorders and syndromes(dementia,psychoactive substance use,acute psychotic disorder,schizophrenia,bipolar affective disorder,major depressive disorder,obsessivecompulsive disorder,personality disorders and intellectual disability).The prevalence of aggressive behavior and its underlying risk factors,such as sex,age,comorbid psychiatric disorders,socioeconomic status,and history of aggressive behavior are discussed as these are the components that mostly contribute to the increased risk of aggressive behavior.Measurement tools commonly used to predict and detect aggressive behavior and to differentiate between different forms of aggressive behavior in both research and clinical practice are also reviewed.Successful aggression prevention programs can be developed based on the current findings of the correlates of aggressive behavior in psychiatric patients. | Hunor Girasek Vanda Adél Nagy Szabolcs Fekete Gabor S Ungvari Gábor Gazdag | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 6 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 7 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 8 | Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction显示文摘During the production of pharmaceutical tablets using powder compaction,certain common problems can occur,such as sticking,tearing,cutting,and lamination.In the past,the compressibility of the powder was calculated only along the axis of the device;consequently,critical areas of the material throughout the volume could not be identified.Therefore,finite element method(FEM) can be used to predict these defects in conjunction with the use of an appropriate constitutive model.This article summarizes the current research in the field of powder compaction,describes the Drucker-Prager Cap model calibration procedure and its implementation in FEM,and also examines the mechanical behavior of powder during compaction.In addition,the mechanical behavior of pharmaceutical powders in relation to changes in friction at the wall of the system is examined,and the dependence of lubrication effect on the geometry of the compaction space is also investigated.The influence of friction on the compaction process for the flat-face,flat-face radius edge,and standard convex tablets is examined while highlighting how the effects of friction change depending on the shape of these tablets. | Alexander Krok Marin Peciar Roman Fekete | 2014 | Particuology2014，12，5： | 3 |
| 9 | Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease显示文摘AIM: With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the fact whether reflux episodes causing complaints for a long time i.e., at least for one year are associated with metabolic changes in the lower esophageal sphincter, and if so,whether these may influence functional results achieved after anti-reflux surgery.METHODS: Between 1 January 2001 and 31 December 2002 we performed anti-reflux surgery on 79 patients.Muscle samples were taken from the lower esophageal sphincter (LES) in 33 patients during anti-reflux surgery.Inclusion criteria were: LES resting pressure below 10 mmHg and a marked, pH proven acid exposure to the esophagus of at least one year's duration, causing subjective complaints and requiring continuous proton pump inhibitor treatment. Control samples were obtained from muscle tissue in the gastroesophageal junction that had been removed from 17 patients undergoing gastric or esophageal resection. Metabolic and lysosomal enzyme activities and special protein concentrations 16 parameters in total were evaluated in tissue taken from control specimens and tissue taken from patients with GERD. The biochemical parameters of these intra-operative biopsies were used to correlate the results of anti-reflux operations (Visick I and II-III).RESULTS: In the reflux-type muscle, we found a significant increase of the energy-enzyme activities e.g., creatine kinase, lactate dehydrogenase, β-hydroxybutyrate dehydrogenase, and aspartate aminotransaminase-. The concentration of the structural protein S-100 and the myofibrillar protein troponin I were also significantly increased. Among lysosomal enzymes, we found that the activities of cathepsin B, tripeptidyl-peptidase I, dipeptidylpeptidase II, β-hexosaminidase B, β-mannosidase and β-galactosidase were significantly decreased as compared to the control LES muscles. By analyzing the activity values of the 9 patients in Visick groups Ⅱ and Ⅲ at two months post-surgery, we found a significant increase in the activity of the so-called energy-enzyme values and in the concentration of structural and myofibrillar proteins as compared to the rest of the reflux patients.CONCLUSION: Our results call attention to the metabolic changes that occurred in the LES muscles of reflux patients. The developing hypertrophy-like changes of LES muscles may be a reason for complaints after anti-reflux surgery, which consisted mainly of reports of persisting dysphagia. | Aron Altorjay Arpad Juhasz Viola Kellner Gellert Sohar Matyas Fekete Istvan Sonar | 2005 | World Journal of Gastroenterology2005，11，11： | 2 |
| 10 | Insulin induced translocation of Na^+/K^+-ATPase is decreased in the heart of streptozotocin diabetic rats显示文摘 | Klara ROSTA Eszter TULASSAY Anna ENZSOLY Katalin RONAI Ambrus SZANTHO Tamas PANDICS Andrea FEKETE Peter MANDL Agota VER | 2009 | Acta Pharmacologica Sinica2009，30，12： | 2 |
| 11 | 从天然提取物或分离部位中以碳酸酐酶II为靶点的抗骨质疏松活性筛选(英文)显示文摘目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg ml浓度下发现了来源于 40个科、61个属、72个种的 1 0 0个样品有活性 ,其中 5个样品的IC50 小于 2 50 μg ml,2 2个样品的IC50 在 2 51~ 5 0 0 μg ml范围 ,73个样品的IC50 在 5 0 1~1 0 0 0 μg ml范围。通过以上工作我们认为以碳酸酐酶II为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 ,特别适用于天然产物的抗骨质疏松活性筛选。 | 付祥 谭宁华 姜立花 贾锐锐 嵇长久 LANDRO James FEKETE Alexander MUELLER Hartwig HENKEL Thomas | 2003 | 云南植物研究2003，25，6： | 2 |
| 12 | Aggregation of CaCO3 particles in PP composite: Effect of surface coating 显示文摘 | Attila Kiss Erika Fekete Be'la Puka'nszky | 2007 | Composites Science and Technology2007，67，： | 1 |
| 13 | Enterotoxigenic Escherichia coli (ETEC) in farm animal显示文摘 | NAGY B FEKETE P Z | 1999 | VET Res1999，30，： | 1 |
| 14 | The hydrolysis of unsubstituted N-acylhomoserine lactones to their homoserine metabolites Analytical approaches using ultra performance liquid chromatography显示文摘 | Englmann M Fekete A Kuttler C | 2007 | J Chromatography A2007，1160，12： | 1 |
| 15 | New classes of lower bounds for bin-packing problem 显示文摘 | Fekete S P Schepers J | 1998 | IPCO 98 Springer Lecture Notes in Computer Science1998，1412，： | 1 |
| 16 | Enterotoxigenic Escherichia coil(ETEC) in farm animial显示文摘 | NAGY B FEKETE P Z | 1999 | VET Res1999，30，23： | 1 |
| 17 | Lunrbar facet joint effusion in MRI: a sign of instability in degenerative spondylolisthesis? 显示文摘 | Latting F Fekete TF Grob D | 2012 | Eur Spine J2012，21，2： | 1 |
| 18 | Fast and sensitive determination ofpolysorbate 80 in solutions containing proteins 显示文摘 | Fekete S Ganzler K | 2010 | J Pharm Biomed Anal2010，52，5： | 1 |
| 19 | The TRH neuron : a hypothalamic integrator of energy metabolism显示文摘 | Lechan RM Fekete C | 2006 | Proq Brain Res2006，153，： | 1 |
| 20 | In situ synthesis of magnetic multiwalled carbon nanotube composites for the clean - up of ( fluoro ) quinolones from human plasma prior to ultrahigh pressure liquid chromatography analysis 显示文摘 | Morales -Cid G Fekete A Simonet B M | 2010 | Anal Chem2010，82，： | 1 |
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